It’s the final stretch of the college football season, and several conferences have multiple teams that could realistically win and gain a College Football Playoff spot.
Week 10 isn't as loaded as previous weeks, but we still have plenty of enticing matchups, including No. 14 Tennessee hosting No. 18 Oklahoma with both two-loss teams fighting for their playoff lives.
Below, we'll give you the top Saturday CFB DFS Picks for Week 10 on PrizePicks, including player stats and picks for the premier matchups in the PrizePicks cheat sheet.
The SEC highlights the weekend, as it features two of the three ranked bouts. No. 9 Vanderbilt continues its historic season, facing another challenge as it travels to Austin to take on No. 20 Texas at 12:00 p.m. ET on ABC. The big question for the Longhorns is the status of QB Arch Manning, who is questionable with a concussion.
The Big 12 has the other ranked matchup, with No. 17 Cincinnati trying to stay undefeated in-conference as it takes on No. 24 Utah at 10:15 p.m. ET.
Below, we'll dig into the projections for the top players in college football, including QBs Julian Sayin and Trinidad Chambliss, plus many more QBs, RBs, and WRs to target.
PrizePicks is the simplest way to win real money with your CFB picks. Just pick your players, predict More or Less on their projected stats, and cash in if your picks are correct.
Let's dive into the top college football DFS picks for Saturday, November 1, on PrizePicks.
Week 10 Saturday CFB DFS Picks for PrizePicks
Here are the top CFB DFS picks for Week 10, including PrizePicks picks for Ole Miss vs. South Carolina and Oklahoma vs. Tennessee.
Use this analysis to make your PrizePicks DFS picks for Saturday's games.
Ohio State QB Julian Sayin Projection: 253 Passing Yards
Penn State vs. No. 1 Ohio State Pick – 12 p.m. ET
- Sayin has more than 253 passing yards in three of his last five games.
- Sayin leads the FBS with an 80.0% completion percentage.
- Penn State is 89th in opponent completion percentage (64.1%).
- The 2024 five-star recruit’s 64.1% passer success rate leads the nation, per Game on Paper.
- PSU is 39th in opponent passer success rate (44.6%), via CFB Graphs.
- The Nittany Lions are 87th in EPA per dropback (0.037).
Ole Miss Trinidad Chambliss Projection: 52.5 Rushing Yards
South Carolina vs. No. 7 Ole Miss Pick – 7 p.m. ET
- Chambliss has more than 52 rushing yards in three of his last five games.
- In Week 9, the former Ferris State QB ran for 53 yards against Oklahoma, which ranks second in the FBS in rushing yards allowed per game (80.3).
- South Carolina is allowing 151.9 rushing yards per game (69th).
- Chambliss is the first SEC QB since 1994 to throw for 300+ yards and rush for 50+ in his first three starts.
- SC is allowing the fourth-most rushing yards per carry (4.5) to conference opponents.
- Ole Miss is 12th in QB scramble EPA (0.787).
- The Gamecocks are 91st in opposing QB scramble EPA (0.381).
Louisville RB Isaac Brown Projection: 88.5 Rushing Yards
No. 16 Louisville vs. Virginia Tech Pick – 3 p.m. ET
- Isaac Brown has 100+ yard performances in back-to-back games.
- In a 38-24 Week 9 win against Boston College, Brown became the third RB in Louisville history to rush for 200+ yards on fewer than 15 carries.
- Virginia Tech has allowed three RBs to rush for over 100 yards this season.
- The sophomore’s 33 forced missed tackles are the 11th-most in the FBS, per Pro Football Focus.
- The Hokies' 12.6% missed tackle rate ranks 125th.
Oklahoma State RB Rodney Fields: 54.5 Rush+Rec Yards
Oklahoma State vs. Kansas Pick – 4 p.m. ET
- Rodney Fields has more than 54 combined rushing and receiving yards in four of his last five games.
- Oklahoma State’s 60.3% run play percentage in the previous three games is 20th.
- The Jayhawks are 76th in opponent rush EPA (0.007).
- The sophomore has two games with 80+ yards after contact.
- KU is 113th in yards allowed after contact (3.3).
Ohio State WR Carnell Tate Projection: 68.5 Receiving Yards
Penn State vs. No. 1 Ohio State Pick – 12 p.m. ET
- Carnell Tate has more than 100 receiving yards in three of his last five games.
- Tate’s 17.3 yards per reception is fifth in the Big Ten.
- PSU has allowed a WR to post 70+ yards in two of its last three games.
- This is a revenge game for OSU, as their former defensive coordinator, Jim Knowles, left the team for the same job with the Nittany Lions.
Tennessee WR Chris Brazzell II Projection: 71.5 Receiving Yards
No. 9 Vanderbilt vs. No. 20 Pick – 12 p.m. ET
- Chris Brazzell has more than 100 receiving yards in two of his last four games.
- Brazzell leads the SEC with 740 receiving yards.
- Tennessee has the fifth-most completions of 30+ yards (19).
- Brazzell has a reception of 30+ yards in five games this season.
- Oklahoma is 113th in completions allowed of 30+ yards (23).
- The junior has 5+ catches in six of eight games this season.
Make College Football DFS Picks on PrizePicks
Given its three games between top 25 teams, Week 10 of college football could be important with the CFB Playoff schedule set to come out on Tuesday.
Whether you're watching the SEC matchups between Vanderbilt and Texas or Oklahoma and Tennessee, PrizePicks is the best way to cash in on your college football picks.
Just pick your players — including Julian Sayin and Trinidad Chambliss — predict More or Less on their stat projections, and get paid if your picks are correct.
Stay locked in on the Playbook for more CFB DFS picks and college football predictions throughout the 2025 season.
