The second leg of the Arsenal vs. Leverkusen Champions League matchup is set to kick off at 4:00 p.m. ET on Tuesday, March 17, live on Paramount+.
While there were plenty of lopsided outcomes in the first-leg showdowns for the round of 16, Arsenal and Leverkusen are tied at 1-1 on aggregate score entering Tuesday’s clash, making this the deciding fixture.
Can Bayer Leverkusen find a way to pull off an unexpected upset in a hostile environment, with Arsenal clear home favorites?
Below, we’ll discuss our Arsenal vs. Leverkusen Champions League prediction and picks for Tuesday’s match at Emirates Stadium. Use PrizePicks and PrizePicks Team Picks to make your Champions League predictions on players, goal totals, match winners, and more to earn money if you're right!
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Arsenal vs. Leverkusen Prediction, Picks for Champions League – Tuesday, March 17
Arsenal currently find themselves comfortably atop the Premier League table, and they haven’t lost a match across all competitions since January 25 against Man United. The Gunners could be without DF Jurrien Timber for Tuesday’s contest after he didn’t train with the team on Monday.
As for Leverkusen, they are sitting in the No. 6 spot in the Bundesliga standings with a 1-5-0 record over their last six games in all competitions — not a great way to enter a game vs. one of the Premier League's top sides.
Arsenal vs. Leverkusen Spread, Total Goals, Payouts – 3/17/26
Leverkusen enters Tuesday’s match as huge road underdogs, returning a 9.09x payout ($100 entry pays out $909) on PrizePicks Team Picks if they win outright.
Arsenal are home favorites with a 1.26x ($126 payout on a $100 entry) payout if they secure a victory, via PrizePicks Team Picks.
Winner Payout: Leverkusen – 9.09x | Tie – 5.88x | Arsenal – 1.26x
Spread: Arsenal -1.5 (1.78x Payout)
Total Goals: 2.5 (Over – 1.66x)
Both Teams to Score: Yes 2.12x | No 1.72x
Team Picks data is live at the time of writing and is subject to change. Does not include extra time or penalties.
Arsenal vs. Leverkusen Prediction on Total Goals for Tuesday, March 17
Here are some stats to know to help you make your Arsenal vs. Leverkusen prediction on total goals for Tuesday, March 17, in the 2026 Champions League Round of 16. Check out more of our soccer picks and predictions on Playbook.
- Leverkusen has failed to score more than 1 goal in each of their last two Champions League matches.
- In their last five UCL matches, Bayer Leverkusen has had fewer than 3 total goals in four of them.
- Both of these teams pride themselves on the defensive end of the pitch, with Arsenal allowing the fewest goals per match (0.6) in the Champions League.
- Leverkusen has surrendered the 10th-fewest goals per match (1.4) across their 11 UCL games.
- Arsenal has given up 1 or fewer goals in six consecutive matches in all competitions.
- Up to this point, Arsenal has coughed up the fewest expected goals (7.1) throughout the entire UCL tournament.
- The Gunners are tied with Leverkusen for the second-most clean sheets (5) in the Champions League.
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Arsenal vs. Leverkusen Lineups for Tuesday, March 17
Here are the official Arsenal vs. Leverkusen lineups for today's Champions League match on Tuesday, March 17. Lineups are official as of publishing.
Arsenal XI vs. Leverkusen
Arsenal Lineup: Raya; White, Saliba, Gabriel, Hincapie; Zubimendi, Rice, Eze; Saka, Trossard; Gyökeres.
Substitutions: Kepa, Ranson, Mosquera, Calafiori, Lewis-Skelly, Norgaard, Madueke, Dowman, Martinelli, Jesus, Havertz.
Leverkusen XI vs. Arsenal
Leverkusen Lineup: Blaswich; Quansah, Andrich, Tapsoba; Poku, Palacios, Aleix Garcia, Grimaldo; Terrier, Maza; Kofane
Substitutions: Jonas Omlin; Niklas Lomb; Tim Oermann, Axel Tape; Ezequiel Fernández, Malik Tillman; Jonas Hofmann; Patrik Schick; Montrell Culbreath
Arsenal vs. Leverkusen Picks for Champions League: Tuesday, March 17
Here are two Arsenal vs. Leverkusen picks to target on players for Tuesday, March 17. Player picks via PrizePicks are headlined by Bukayo Saka and David Raya.
Arsenal F Bukayo Saka vs. Leverkusen
Bukayo Saka Projections via PrizePicks: 0.5 Shots on Target (Goblin), 0.5 Goal + Assist (Goblin)
- In Arsenal’s nine Champions League matches, Bukayo Saka leads the squad in shots per 90 minutes (4.1).
- Saka also has the second-most shots on target per 90 (2.1) for the Gunners.
- Besides Saka having corner and penalty responsibilities for Arsenal, he’s recorded a goal or assist in four of his seven UCL appearances.
Arsenal GK David Raya vs. Leverkusen
David Raya Projections via PrizePicks: 1.5 Goalie Saves (Goblin), 0.5 Goals Allowed
- David Raya has made multiple saves in each of his last three starts in the UCL.
- Across his last eight starts in all comps, Raya has tallied 2 or more saves in seven of them.
- Raya has kept a clean sheet in five of his eight outings against Champions League opponents.
Make Your Arsenal vs. Leverkusen Prediction on PrizePicks
If Arsenal wants to achieve winning the Premier League and Champions League this season, they’ll need to be a bit more aggressive on Tuesday.
Comparatively, Leverkusen doesn’t have much pressure as massive underdogs on the road, which
You can make your Arsenal vs. Leverkusen picks on PrizePicks and PrizePicks Team Picks to earn real money on Champions League games. Just pick players, predict More or Less on their projected stats like shots or goals, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states.
Stick around with the Playbook for continued Champions League predictions, picks, and analysis until a champion is crowned.
