Como vs. Man United Prediction, Picks, XIs for Champions League – 10/21/26

Wednesday’s Champions League slate will get started with Como hosting Manchester United at 12:45 p.m. ET. Como enters the Champions League match as home favorites, with a 2.22x payout to win on PrizePicks.

Both Como and Man United are hoping to bounce back from losses in Matchweek 2 of the UCL. Como lost 3-2 to Feyenoord, while Manchester United was blanked 2-0 by Atlético Madrid.

Below, we’ll discuss our Como vs. Man United prediction and picks for Wednesday’s Champions League match for PrizePicks.

Make your Como vs. Man United prediction on PrizePicks now!

{{soccer_offer_banner="/style-system/ui-components-playbook"}}

Como vs. Man United Prediction, Picks for Champions League – Wednesday, October 21

Como enters Wednesday’s game as home favorites against Man United, returning a 2.22x payout if they win outright, via PrizePicks.

Meanwhile, Manchester United will look to secure a victory as road underdogs, with a 2.77x payout to win. PrizePicks also has a 3.44x payout on a draw between the two sides.

Here are the full payouts for the Como vs. Man United game on PrizePicks. PrizePicks data is live at the time of writing and is subject to change.

Make your Como vs. Man United prediction on total goals on PrizePicks!

How to watch Como vs. Man United: Paramount+ (English) / UniMás (Spanish)

Kick-off time: 12:45 p.m. ET

Venue: Stadio Giuseppe Sinigaglia, Como, Italy

Entering Matchweek 3, Como are in fifth place in their domestic league (Serie A) with 14 points and a 4-2-1 record. The Italian hosts were in league below Serie A (Serie B) in the 2023-2024 season, so it’s been an impressive ascent for Como.

To earn the fifth spot in Serie A, manager Cesc Fábregas’s side has gotten results by maintaining possession and generating scoring chances consistently. According to FotMob, Como has the second-highest average possession (61.0%) and the second-most shots on target per match (6.9) in the top-flight Italian league this season.

Before losing to Feyenoord in Matchweek 2 of the Champions League, Como began their UCL campaign with a lopsided 4-1 win over RB Leipzig.

After electing to stick with manager Michael Carrick this year, Manchester United are sitting at 13th in the Premier League table with 7 points and a 1-4-2 record. The Red Devils are currently on a six-match winless streak, with their latest game being a 1-1 draw against Leeds United on Sunday, October 18.

The last time Man United fans witnessed a victory by the club was on September 10, when Carrick’s side defeated Sabah FK 4-0 in the team’s Champions League opener.

Although Manchester United is sixth in xG (11.6) and seventh in xG difference (1.8) in the Premier League, they’ve continuously found ways to fall short of expectations.

{{soccer_offer_banner="/style-system/ui-components-playbook"}}

Como vs. Man United Prediction on Winner for Champions League – 10/21/26

Here are some stats to know to help you make your Como vs. Man United prediction on total goals scored for Wednesday, October 21. Check out more of our soccer picks and predictions on Playbook.

• Among the 36 teams in the Champions League group stage, Como has the second-highest shot conversion rate (24.0%), per Opta Analyst.
• Meanwhile, Man United is 18th in shot conversion rate (13.3%) in their first two UCL games.
• The Red Devils are winless in their five away matches in 2026, going 0-3-2.
• Manchester United has also failed to keep a clean sheet in nine of their first 11 matches in all competitions.
• On the other hand, Como has kept a clean sheet in two of their last four games.
• Como has taken care of business at home this season, going undefeated (2-1-0) in their first three matches as the host team across all competitions.

Lock in your Como vs. Man United prediction on PrizePicks now!

Como vs. Man United Projected Lineups for Champions League – Wednesday, October 21

Here are the projected Como vs. Man United lineups for today's Champions League match. Lineups are not official and should be confirmed before the match starts.

Como Lineup vs. Man United: Projected 4-2-3-1

• Goalkeeper: Robert Sánchez
• Defense: Álex Valle, Jacobo Ramón, Alberto Dossena, Ivan Smolcic
• Midfield: Luis Milla, Martin Baturina, Máximo Perrone
• Forwards: Kaiki, Nico Paz, Jesús Rodríguez

Man United Lineup vs. Como: Projected 4-2-3-1

• Goalkeeper: Senne Lammens
• Defense: Diogo Dalot, Lisandro Martínez, Harry Maguire, Ayden Heaven
• Midfield: Andrey Santos, Bruno Fernandes, Youri Tielemans
• Forwards: Marcus Rashford, Bryan Mbeumo, Amad Diallo

Como vs. Man United Picks, Player Picks, Stats for PrizePicks: 10/21/26

Here are Como vs. Man United picks to target for the Champions League on PrizePicks for Wednesday, October 21. Today’s UCL picks include Nico Paz and Senne Lammens.

Como ST Nico Paz vs. Man United: 3.5 Shots

• Paz has tallied at least 4 shots in six of his nine matches in all competitions this year.
• Against Serie A opponents this season, Paz has the second-most shots per 90 minutes (5.5) on Como’s roster.
• Como has the seventh-most big chances created (10) across their first two Champions League games, so Paz will have opportunities against a vulnerable United backline.

Add Nico Paz to your PrizePicks lineup now.

Man United GK Senne Lammens vs. Como: 3.5 Goalie Saves

• Lammens is tied for the third-fewest saves made (3) among all GKs in the UCL.
• In his last five starts in the Premier League and Champions League, Lammens has fewer than 4 saves in four of them.
• Furthermore, in his seven starts in the EPL this season, Lammens has less than 4 saves in five.

Add Senne Lammens to your PrizePicks lineup now.

{{soccer_offer_banner="/style-system/ui-components-playbook"}}

Make Your Como vs. Man United Picks on PrizePicks

Como has seemingly found an identity early in the Serie A season, and they’re in much better form than Man United right now. Will Como add another victory at home, or will Manchester United get out of their funk as underdogs on Wednesday?

Don’t wait until kickoff — make your Como vs. Man United picks for Wednesday’s Champions League match now on PrizePicks to earn real money.

Just pick your Champions League players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on the match winner, total goals, and both teams to score — now available in 36 states.

Stay locked in with the Playbook for continued soccer and Champions League predictions, picks, and analysis.