The Tuesday MLB slate is full of daytime action and several key games with top pitchers on the mound in tonight's games.
Today's MLB predictions will focus on the interleague battle between the Milwaukee Brewers (8-2) vs. Boston Red Sox (2-8) at 6:45 p.m. ET, followed by the Philadelphia Phillies (6-43) vs. San Francisco Giants (3-8) at 9:45 p.m. ET.
Which MLB contests could bring the best value for picks on PrizePicks Team Picks and PrizePicks? Below, we’ll highlight two games for MLB predictions and expert picks in Tuesday's MLB games.
{{mlb_offer_banner="/style-system/ui-components-playbook"}}
Best MLB Predictions and Expert Picks: 4/7/26
The Milwaukee Brewers rallied past the Red Sox last night, 8-6, marking their fifth scoring output of at least 8 runs.
The San Francisco Giants squandered a 4-0 lead in Monday’s 6-4 defeat to the Phillies, extending their losing streak to four games.
Keep tabs on Playbook’s MLB coverage for predictions on baseball all season leading up to the World Series. Let’s dive into our favorite MLB predictions and expert picks for Tuesday, April 7, on PrizePicks Team Picks.
Payouts are live as of publishing. All are subject to change.
Milwaukee Brewers vs. Boston Red Sox Prediction to Win – 4/7/26
Game Winner Payout: Milwaukee Brewers (2.17x) | Boston Red Sox (1.63x)
Time: 6:45 p.m. ET
TV: MLB.tv
- The Red Sox started the season with a victory at Cincinnati, but have lost eight of nine games to own the worst record in MLB.
- The Brewers sit behind the Dodgers and Astros in wOBA at .364 and rank first in BABIP at .347, according to Fangraphs.
- Milwaukee P Jacob Misiorowski has compiled 18 strikeouts through two starts.
- The right-hander has posted eight outings in his short career of at least 7 Ks.
- Boston P Garrett Crochet continues to be one of the leaders in K%, putting together a 31.9% through two starts. Last season, the southpaw delivered a 31.3% K rate, while leading the league with 255 strikeouts.
- In 2025, the Red Sox lost five of Crochet’s first six starts at Fenway Park, but Boston went 7-1 in his final eight home outings. Crochet makes his first home start of 2026 tonight.
- Milwaukee won the past four meetings with Boston, including a 3-2 victory over Crochet last May.
- The left-hander struck out 11 batters in 6.2 innings in the loss.
- The Brewers are 3-0 in three games against left-handed starting pitchers this year, averaging 7.6 runs per game.
- Boston’s top bats aren’t coming through as SS Trevor Story, LF Jarren Duran, RF Roman Anthony, and 3B Caleb Durbin all own xBA of .224 or below.
{{mlb_offer_banner="/style-system/ui-components-playbook"}}
Philadelphia Phillies vs. San Francisco Giants Prediction on Winner – 4/7/26
Game Winner Payout: Philadelphia Phillies (1.61x) | San Francisco Giants (2.27x)
Time: 9:45 p.m. ET
TV: MLB.tv
- The Giants have been dreadful at home this season, winning once in eight tries.
- San Francisco has scored 10 runs in its seven home losses, while topping the 4-run mark only three times in 11 games.
- Phillies P Cristopher Sanchez compiled 17 strikeouts in two starts, as his K rate sits at 37.8%.
- In two outings against the Giants last season, Sanchez struck out 12 and 8 batters, although he lost at San Francisco, 3-1.
- San Francisco P Robbie Ray posted 7 Ks in his last start against the Mets, his seventh home performance of at least 7 strikeouts since the beginning of 2025.
- The Giants won each of Ray’s two starts against the Phillies last season, striking out 13 batters.
- The Phillies are 1-3 in four games against left-handed starting pitchers. The lone victory came against an opener in a 2-1 win at Colorado last Saturday.
- San Francisco is 0-6 at home against right-handed starters, but 1-1 when facing southpaw starters.
{{mlb_offer_banner="/style-system/ui-components-playbook"}}
Phillies 1B Bryce Harper vs. Giants: 5.5 Hitter Fantasy Score
- On Monday vs. the Giants, Harper put up his best offensive performance of the season, going 3-for-4 with 3 RBI.
- He compiled 23 points on Monday, his third fantasy score of at least 14 in the last five games.
- Harper is batting 6-for-15 against Ray, including a pair of home runs and 4 RBI.
- His road numbers are significantly better than at home, owning a .733 slugging percentage and OPS of 1.145 away from Citizens Bank Park.
Make MLB Predictions Today on PrizePicks
Can the Red Sox turn things around against the red-hot Brewers? Will the Giants rebound against a Phillies’ squad seeking their fifth win in the last six games? Those are just two spots to watch on a loaded MLB slate on Tuesday.
You can make your picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, you can make predictions on MLB game winners, run lines, and total, now available in 35 states.
Stick around with the Playbook for continued MLB predictions, picks, and news throughout the 2026 season.
