The 2025 NFL season is underway with 13 games on Sunday, highlighted by a late-afternoon tilt between a pair of NFC North rivals: The Detroit Lions, coming off of their second consecutive NFC North title, travel to historic Lambeau Field to face the Green Bay Packers at 4:25 p.m. ET on FOX.
We'll break down our Lions vs. Packers prediction for Sunday in Week 1 below, including the top player picks on PrizePicks' real money NFL game, among them Lions QB Jared Goff and RB Jahmyr Gibbs, and Packers QB Jordan Love.
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Lions vs. Packers Prediction, Preview for 9/7/25
The Lions won a franchise-record 15 games last season, claiming the top-seed in the NFC, before losing to the Washington Commanders in the Divisional Round. They swept the Packers in the season series and have won five of the last six against Green Bay's finest.
The Pack won 11 games in 2024, earning a Wild Card berth before falling to the eventual Super Bowl Champion Eagles in the Wild Card round.
Detroit Lions Preview
A stellar regular season with a franchise-record 15 wins ended in disappointment when the Lions fell 45-31 to the Washington Commanders in their lone 2024 postseason contest.
The Lions led the NFL with 33.2 points per game last season, were second in total offense with 409.5 yards per game, and second in passing offense at 263.2 yards per game.
Detroit's main offensive pieces are back in QB Jared Goff, RBs Jahmyr Gibbs and David Montgomery, and WRs Jameson Williams and Amon-Ra St. Brown.
It was Detroit's defense that let the team down late last year, as they allowed 30-plus points in three of the last five games, then 45 to the Commanders in the playoffs. For the season, their pass defense ranked 30th in the NFL and dead last in the NFC.
In the offseason, the Lions signed veteran CB D.J. Reed to a $48M deal to pair him with Terrion Arnold and shore up the secondary.
The Lions have won their last three games on the road in Green Bay.
Green Bay Packers Preview
The Packers were 11-4 last season against all teams not named the Detroit Lions, and that included losses in their last two regular season games.
After winning the NFC North from 2019-21, the Packers missed the postseason in 2022 and rebounded with back-to-back Wild Card appearances.
One thing Green Bay hasn't done often is beat the Lions, going 1-5 during the last three seasons, including an 0-3 record at home.
QB Jordan Love has one win in four starts against the Lions, with 6 passing TDs and 5 INTs.
The Packers made headlines last month, trading two future No. 1 draft picks and DT Kenny Clark to the Dallas Cowboys for four-time Pro Bowl edge rusher Micah Parsons.
The Packers ended 2024 allowing the fourth-fewest points per game and fifth-fewest yards.
Lions vs. Packers Picks for NFL DFS & PrizePicks
Lions QB Jared Goff Projection vs. Packers: 1.5 Pass TDs
As Lions field general, Goff is 6-2 facing the Packers, averaging 226.9 passing yards per game with 13 TDs and 4 INTs. In the 2024 season sweep, Goff completed 50 of 63 passes (79.4%) with 4 TDs and 1 INT.
As a Lion, Goff has thrown for 2-plus TD passes in five of his eight games against the Packers.
Packers QB Jordan Love Projection vs. Lions: 0.5 INTs
Love has one win in five games (four starts) against the Lions, with 6 passing TDs and 5 picks. In the two losses last season, Love completed 35 of 59 passes (59.3%) with 1 TD and 1 INT.
Love has thrown an interception in three of his five career games against the Lions. The last time we saw Love, he threw 3 INTs in a Wild Card Round loss to the Eagles.
Lions RB Jahmyr Gibbs Projection vs. Eagles: 3 Receptions
In four career games facing the Packers, Gibbs hauled in 12 total receptions.
The former Alabama star recorded 3-plus receptions in the last six games in 2024, and in 11 of 18 overall, including postseason.
For his career, the two-time Pro Bowler has 3-plus receptions in 23 of 36 games.
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Will the Lions continue their domination of the Packers and get an early leg up for their third straight NFC North title? Or will the Packers hold serve at home and serve notice there could be a changing of the guard in the North?
As the NFL season gets started, there's no better place to get real money action with your NFL predictions than on PrizePicks.
There's a wide variety of player stat projections on our NFL board, so you can make predictions on whatever you'd like, from yards to field goals. Just pick at least two players and pick More or Less on their stats to build your Lineup on PrizePicks.
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