The Detroit Pistons (56-21) face the Philadelphia 76ers (43-34) in an Eastern Conference matchup that could have an impact on the playoff standings on Saturday, April 4.
The Pistons are 3.5-point favorites on the spread vs. the 76ers for tonight’s game at 7:00 p.m. ET on NBA TV, per PrizePicks Team Picks.
Below, we’ll break down our Pistons vs. 76ers prediction and picks for today's game. Make your NBA picks on PrizePicks and earn real money if you’re right, including on game winners, spreads, and totals!
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Pistons vs. 76ers Prediction, Spread, Over/Under
The Pistons face the challenge of keeping the No. 1 seed in the Eastern Conference without star G Cade Cunningham, who could miss the rest of the regular season due to a collapsed lung.
They are playing well with a 6-2 record since Cunningham’s absence, and the offense is effective, shooting 50.3% from the floor since March 17 (seventh during the split).
Detroit is shifting the narrative for anyone who believes they can’t contend without Cunningham in the lineup.
The 76ers are a team to watch due to their recent stretch. They have rarely played with their full lineup this season; C Joel Embiid has played just 36 games due to injury, and F Paul George was suspended for 25 games due to a PED violation. However, with those two back in the lineup, the Sixers look like a competitor.
They have won 8 of their last 12 games. Embiid has led the team in points in three of their last five, and George has totaled 62 points in his last two games. If Philly has this lineup during the playoffs, it could make some noise.
Pistons vs. 76ers Spread, Over/Under
The 76ers enter Saturday’s game as 1.5-point home underdogs, returning a 2.17x payout on PrizePicks Team Picks if they win outright.
The Pistons are road favorites with a 1.66x payout if they win, via PrizePicks Team Picks, where you can earn money with your picks in 35 states.
- Spread: Detroit Pistons -1.5
- Over/Under: 224.5
- Game Winner Payout: Pistons 1.66x | 76ers 2.17x
Team Picks data is live at the time of writing and is subject to change.
Pistons vs. 76ers Injury Report
Let’s dive into the full Pistons vs. 76ers injury report on Saturday, via NBA.com.
Pistons Injury Report
- G Cade Cunningham (lung): OUT
- C Jalen Duren (illness): Questionable
- C/PF Isaiah Stewart (calf): OUT
- F Tobias Harris (knee): Questionable
76ers Injury Report
- C Joel Embiid (oblique): OUT
- F Paul George (knee): Probable
Pistons vs. 76ers Prediction on Spread – 4/4/26
Here are the key stats to know before locking in your Pistons vs. 76ers prediction on the spread for Saturday, April 4, on PrizePicks.
- The 76ers are shooting at a high volume recently; since March 14, they lead the league, averaging 94.0 field goal attempts per game at home.
- Since March 14, Philadelphia is fifth with 46.8 rebounds per game.
- Detroit could be the team that stops momentum. Over their last 10 road games, the Pistons are allowing the fewest rebounds per game (37.5).
- The Pistons give up the second-fewest field goal attempts per game (85.2).
- Detroit is a confident team to back, covering the spread in eight of its last nine games.
- The 76ers have failed to cover in six of their last eight games as an underdog, including their last matchup vs. the Pistons.
Pistons vs. 76ers Picks for PrizePicks Today: 4/4/26
Here are the top Pistons vs. 76ers picks to target for Saturday, April 4, on PrizePicks. Pistons C Jalen Duren and 76ers G Tyrese Maxey headline today’s NBA picks for PrizePicks.
Pistons C Jalen Duren vs. 76ers Projection: 34.5 Pts + Rebs
- Duren is stepping up for the Pistons during Cunningham’s absence. Since March 18, he has led the team with 23.3 points and 7.1 rebounds per game.
- According to BettingPros, since March 19, the 76ers have allowed the eighth-most points per game (26.8) and the sixth-most rebounds per contest (16.7) to centers.
- The center out of Memphis has exceeded his combined points and rebounds projections in 8 of 12 games without Cunningham.
- According to databallr, the fourth-year veteran is effective at the rim, averaging 10.0 shots per game (99th percentile) while shooting 72.5% at the rim (71st percentile).
- The 76ers rank 15th, allowing 64.7% field goal percentage at the rim.
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76ers G Tyrese Maxey vs. Pistons Projection: 6.5 Assists
- The former Kentucky guard is averaging 5.8 assists per game over his last 10 games, below his season average of 6.7.
- Maxey has failed to surpass his assist total in four of his last seven games.
- In the three matchups he has gone over, two of those opponents ranked in the bottom 12 of assists allowed per game.
- The Pistons are allowing the fewest assists per game (23.5).
- The 2020 first-round pick logs 15.4 potential assists per 100 possessions, and that's only in the 56th percentile, per databallr.
Make Pistons vs. 76ers Picks on PrizePicks
The Pistons and 76ers are in the mix of a highly contested playoff battle in the East, adding high stakes to tonight's game.
You can make your Pistons vs. 76ers picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states.
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