The Carolina Panthers sit at 7-6, and the path for their first NFC South title in a decade became much clearer after the Bucs lost on Thursday night.
The Panthers road to win the division will have to start on the road vs. the Saints in Week 15 at 4:25 p.m. ET on FOX.
Below, we’ll break down our Panthers vs. Saints prediction and Sunday Week 15 picks for PrizePicks. Use PrizePicks NFL to make picks on player projections and win real money if you’re right.
Panthers vs. Saints Prediction, Spread, & Over/Under
It’s not the Broncos vs. Packers game, which headlines a loaded Week 15 NFL slate, but this Panthers vs. Saints showdown carries a ton of intrigue in its own right, both in real-life stakes and fantasy implications.
The Panthers opened the week as 1.5-point favorites vs. the Saints. Since then, we have seen them move to 3.5-point favorites on PrizePicks Team Picks. The over/under opened the week at 43.5 and has since moved down to 39.5 as of writing, which is the third-lowest total on the Week 15 slate.
The Panthers clearly used their Week 14 bye to get healthy, as they come into Week 15 with a completely clean bill of health. Not a single player was listed on this week’s final injury report.
Star RB Alvin Kamara (knee/ankle) remains out for the Saints for the third-straight week. Rookie RB Devin Neal (abdomen) — the most likely beneficiary of Kamara’s absence — logged a full practice on Friday and should be ready to carry the load on Sunday.
Panthers vs. Saints Over/Under, Spread
The Panthers enter Sunday’s game as 3.5-point road favorites, returning a 1.56x payout on PrizePicks Team Picks if they win outright.
The Saints are home underdogs with a 2.27x payout if they win, via PrizePicks Team Picks.
- Spread: Carolina Panthers -3.5 (2.08x payout)
- Over/Under: 39.5 (1.72x payout on Over)
- Game Winner Payout: Panthers 1.56x | Saints 2.27x
Team Picks data is live as of writing and is subject to change.
Panthers vs. Saints Prediction on Spread for NFL Week 15
Here are some stats to know to get you prepared for Panthers vs. Saints, including a Week 15 spread prediction.
- Underdogs in games with a total below 42 points have covered the spread at a rate of 58.4% since 2018.
- The Saints have played the 12th toughest strength of schedule (SOS) in the NFL, while the Panthers have played the 25th easiest SOS.
- The Saints have the third-best run defense in the NFL, with a -0.09 expected points average (EPA) per rush. The Panthers' easiest route to move the ball could depend on the arm of QB Bryce Young.
- Young has a 64.7 PFF grade, 30th out of 41 qualifying QBs, with 9 INTs (30th), with just 15 big-time throws this season (16th). He’s projected for 195.5 pass yards on PrizePicks.
- Saints QB Tyler Shough has a 73.7 PFF grade, with a 1.83% turnover-worthy play rate. Shough is projected for 206.5 pass yards on PrizePicks.
- Working against the Saints is the fact that they are 5-8-0 against the spread (ATS) in 2025, tied for fourth worst in the NFL.
- The Saints also have an ATS +/- of -3.2, seventh worst in the NFL.
- The Panthers have dropped 11 straight games when they're favored.
Panthers vs. Saints Picks for NFL Week 15
Here are the top Panthers vs. Saints picks for NFL Week 15 on PrizePicks in this NFC South matchup — pick More or Less on player stat projections and cash in if you’re right.
Saints RB Devin Neal vs. Panthers Projection: 55.5 Rush Yards
- The Panthers have the 24th-ranked run defense in EPA (.01).
- In a two-game sample size as a full-time starter, Neal has rushed for an average of 56.5 yards per game.
- Those two games came against a Dolphins run defense that has been 2nd in EPA vs. the run since Week 8 and a top-five ranked Bucs run defense.
- As a full-time starter, Neal has had 17 and 20 touches in back-to-back weeks while playing 82% and 71% of the snaps.
- Opposing teams have chosen to run on the Panthers at the eighth-highest clip in the league — 45.1% of the time.
Saints QB Tyler Shough vs. Panthers Projection: 206.5 Pass Yards
- The Panthers have the 27th-ranked pass defense in expected points average (EPA) at .10.
- Rookie Tyler Shough has surpassed this passing yards number in three of his last four starts.
- One of those four was a 282-yard performance in Week 11 on the road vs. these same Panthers.
- As 3.5-point underdogs, the Saints project to be trailing and in a negative to neutral game script throughout the game, which could lead to an elevated number of pass attempts for Shough.
- The Panthers give up the league's seventh-most yards per pass attempt (6.9) and ninth-most yards per completion (10.6).
- Among NFL QBs, Shough has the eighth-highest passing grade increase in a clean pocket compared to under pressure, per PFF. The Panthers rank dead last in the NFL in pressure rate.
Make Panthers vs. Saints Picks on PrizePicks
The Panthers have a shot to solidify their place in the NFC South championship with a win in New Orleans. Meanwhile, the Saints will ride the rookie duo of QB Tyler Shough and RB Devin Neal, looking for their second-straight win.
In the Panthers vs. Saints game in NFL Week 15, there are plenty of players to consider for your PrizePicks picks. Just pick players, predict More or Less for their projected stats, and earn real money if you’re right.
Keep it locked in here with PrizePicks and the Playbook for continued NFL picks, predictions, and news all season long.
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