The Cleveland Cavaliers vs. Detroit Pistons Game 5 is set to tip off at 8:00 p.m. ET on Wednesday, May 13, with the Pistons entering as 3.5-point favorites on the PrizePicks Team Picks spread.
The Cavaliers produced a strong second-half performance and recorded a massive Game 4 win at home to even the Eastern Conference semifinal series. With the set shifting to Detroit for Game 5, can the Pistons get back on track after losing two consecutive contests?
Below, we'll break down our Cavaliers vs. Pistons prediction and picks for Wednesday’s NBA Playoff game, including the spread, over/under, and key player picks for PrizePicks.
Make your Cavaliers vs. Pistons prediction on PrizePicks for tonight's Game 5.
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Cavaliers vs. Pistons Prediction, Spread, Over/Under for Game 5 – Wednesday, May 13
Home court has certainly played a huge role in this Eastern Conference semifinals series. Each team has won its two home games and covered the spread in those contests so far.
The Cavaliers kept that theme on track in Game 4 with a 112-103 win, outscoring their counterparts 60-47 in the third and fourth quarters. SG Donovan Mitchell led the way by tying an NBA Playoff record with 39 points in the second half. Mitchell finished with 43 points on 13-of-26 shooting, including four 3-pointers, in the spectacular showing.
Cleveland’s defense shut down Detroit star PG Cade Cunningham, limiting him to just 6-of-19 shooting. In addition, the Cavaliers forced the Pistons to turn the ball over 20 times.
Cavaliers vs. Pistons Spread, Over/Under for Game 5 – Wednesday, May 13
The Pistons enter Wednesday’s game as 3.5-point home favorites against the Cavaliers, returning a 1.53x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Cavaliers vs. Pistons game on PrizePicks.
- Spread: Detroit Pistons -3.5 (1.85x payout)
- Over/Under: 212.5 (1.81x payout on Over)
- Game Winner Payout: Cavaliers 2.38x | Pistons 1.53x
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Team Picks data is live at the time of writing and is subject to change.
Cleveland Cavaliers vs. Detroit Pistons Timeline
Here is the full Cavaliers vs. Pistons timeline, including the playoff series game-by-game and recent matchup history.
All-Time: Pistons, 143-17
Regular Season: Tied 2-2
Series: Tied 2-2
Cavaliers vs. Pistons Eastern Conference Semifinals Timeline, Schedule for 2026 NBA Playoffs
- Game 1: Pistons 111, Cavaliers 101
- Game 2: Pistons 107, Cavaliers 97
- Game 3: Cavaliers 116, Pistons 109
- Game 4: Cavaliers 112, Pistons 103
- Game 5: Wednesday, May 13, 8:00 p.m. ET in Detroit
- Game 6: Friday, May 15, TBD in Cleveland
- Game 7 if necessary
Cavaliers vs. Pistons Prediction on Spread for Game 5
Here are the key game stats and trends behind our Cavaliers vs. Pistons prediction on the spread for Wednesday, May 13.
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- The home team is 4-0 against the spread in the Eastern Conference semifinals.
- According to NBA Advanced Stats, the Pistons possess the third-best defensive rating (106.1) among NBA Playoff teams.
- The Pistons are shooting 35.8% from deep throughout the playoffs, ranking fifth. In two home games in the series, Detroit has connected on 44.4% (24 of 54) of its shots from long range.
- The Cavaliers haven’t taken care of the basketball, averaging 15.5 turnovers per game (second-to-last among playoff teams).
- Detroit has logged 44.6 rebounds per game throughout the NBA postseason, good for fifth. In addition, the Pistons secure the second-most offensive rebounds per contest (12.9) this postseason.
- The Pistons are 4-2 ATS in their last six home games vs. the Cavaliers.
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Cavaliers vs. Pistons Picks, Player Stats for PrizePicks: 5/13/26
Here are the top Cavaliers vs. Pistons picks to target in the NBA Playoffs on PrizePicks for Wednesday, May 13. Today’s NBA picks for PrizePicks include SG Donovan Mitchell and PG Cade Cunningham.
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Cavaliers SG Donovan Mitchell vs. Pistons Projection: 26.5 Points
- Mitchell has averaged 33.0 PPG thus far in the Eastern Conference semifinals.
- The Cavaliers’ star SG has averaged 23.3 shot attempts, a significant increase from his 20.0 mark during the regular season.
- According to Add More Funds, Mitchell owns a 32.4% usage rate, leading Cleveland.
- Mitchell has scored 31+ points in each of his last three games, including a 43-point performance in Game 4.
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Pistons PG Cade Cunningham vs. Cavaliers Projection: 41.5 Pts + Rebs + Asts
- Cunningham has averaged a combined 36.6 points, rebounds, and assists in the series up to this point.
- The star PG is shooting just 39.5% (30 of 76) in the first four games of the Eastern Conference semifinals.
- Cunningham has recorded 42 PRA only once in the series.
- The Pistons’ franchise player is shooting 40.9% from beyond the arc in the series but knocked down just 34.2% of his 3-point shots during the regular season.
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NBA Playoffs Live Picks: Cavaliers vs. Pistons on PrizePicks for Game 5
Here are some in-game angles to target for your Cavaliers vs. Pistons live picks in tonight’s game.
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- The Pistons have been one of the NBA’s most productive second-quarter teams, averaging 30.0 PPG (second in the league). Meanwhile, the Cavaliers average 27.7 PPG in the second quarter, which ranks 26th.
- According to NBA Advanced Stats, the Cavaliers own the third-best pace of play (97.27) this postseason, behind only the Denver Nuggets (99.33) and Minnesota Timberwolves (99.33).
- The Cavaliers close out their games on a very strong note, averaging an NBA-best 29.6 PPG in the fourth quarter.
- Cleveland PG James Harden is actually more productive on the road. In away contests, he's averaged 25.1 PPG and shot 37.9% from deep, compared to 21.9 PPG and 37.1% shooting from beyond the arc at home.
Make Cavaliers vs. Pistons Game 5 Picks on PrizePicks
The home team has owned a distinct advantage throughout the Eastern Conference semifinals. With the series returning to Detroit, could the Pistons land in the win column in Game 5?
Don’t wait until tip-off — make your Cavaliers vs. Pistons picks on PrizePicks now and earn real money if you’re right.
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