Trail Blazers vs. Lakers Prediction, Spread, NBA Cup Picks – Friday, November 6

Friday’s nine-game NBA slate will include the Portland Trail Blazers and Los Angeles Lakers squaring off at 10 p.m. ET on Amazon Prime. Before Friday’s NBA Cup group-stage game occurs, the Lakers are slight home favorites and return a 1.61x payout to win on PrizePicks.

The Trail Blazers are on a three-game winning streak and are currently the top seed in the Western Conference with a 6-1 record. This will be Portland’s first NBA Cup game of the season in West Group C.

The Lakers have also won three straight games and sit right behind the Trail Blazers in the standings with a 7-2 record. Los Angeles’ most recent loss came against the Golden State Warriors last Friday, with the purple and gold losing their NBA Cup opener.

Below, we'll break down the matchup for our Trail Blazers vs. Lakers prediction and NBA Cup picks, including the winner, spread, over/under, and player projections on PrizePicks.

Make your Trail Blazers vs. Lakers picks on PrizePicks now!

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Trail Blazers vs. Lakers Prediction, Spread, Over/Under for NBA Cup – Friday, November 6

The Lakers enter Friday’s matchup as 2.5-point home favorites, returning a 1.61x payout if they win outright.

Here are the full payouts for the Trail Blazers vs. Lakers. PrizePicks data is live at the time of writing and is subject to change.

Make your Trail Blazers vs. Lakers prediction on the spread on PrizePicks.

Stats used in this article are from Basketball Reference, NBA.com, or databallr unless stated otherwise.

Head coach Micah Nori has the Trail Blazers playing well-rounded basketball to begin his debut season. Across Portland’s first seven games, it's one of five teams to rank in the top 10 in both offensive rating (120.3) and defensive rating (110.4).

While the Trail Blazers don’t have PG Ja Morant available, PG Damian Lillard (20.1 PPG) and SF Deni Avdija (23.4 PPG) have the offense humming. On the defensive end of the floor, Portland leads the NBA in defensive rebound net rating (+5.4) and excels at finishing possessions on the glass.

Even with the Trail Blazers’ hot start, they return the seventh-lowest payout to win the Western Conference (11.11x) on PrizePicks.

No team has a better offensive rating (121.4) than the Lakers, which isn’t a surprise with how PG Luka Doncic is playing. Doncic is leading the league in scoring (38.5 PPG) and is also producing 8.1 RPG and 8.0 APG.

Doncic has the second-lowest payout to win NBA MVP (2.63x). Only Spurs C Victor Wembanyama returns a lower payout (2.56x) in that market on PrizePicks.

Los Angeles could definitely improve on the defensive side of things, as it currently ranks 19th in rating (113.5). Despite adding C Walker Kessler, the Lakers are dead last in defensive rebound net rating (-4.2).

Trail Blazers vs. Lakers Prediction on Over/Under – 11/6/26

Here are the key stats behind our Trail Blazers vs. Lakers prediction on the over/under for Friday, November 6.

• The Lakers are first in true shooting percentage (64.0%), while the Trail Blazers are fourth (59.6%). 
• Portland has the second-highest 3-point rate (49.7%) and the 12th-highest 3-point percentage (35.4%). L.A.'s respective ranks are eighth (46.5%) and third (38.4%).
• When the Lakers and Trail Blazers faced each other on October 27, the over hit thanks to 265 total points being scored.
• Los Angeles has a league-best 4-1 record to the over when playing at home. The Lakers have achieved the over in five of their last eight games.
• The Trail Blazers are tied for the sixth-best record to the over (3-2) as the road team.

Lock in your Trail Blazers vs. Lakers prediction on PrizePicks before tip-off.

Trail Blazers vs. Lakers Picks, Player Stats for NBA Cup on PrizePicks: 11/6/26

Lakers PG Luka Doncic vs. Trail Blazers: 4.5 3-PT Made

• Doncic has made at least 5 3-pointers in seven of his eight games this season.
• Plus, Doncic has attempted at least 12 threes seven times already.
• In the first meeting between these teams on October 27, Doncic went 6-for-15 on shots from beyond the arc.
• This is a slight pace-up spot for Doncic, as the Trail Blazers play at the 11th-fastest pace (101.3) in the NBA. The Lakers are 15th (100.7).

Add Luka Doncic + Lakers to win to your PrizePicks lineup now.

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Trail Blazers PG Damian Lillard vs. Lakers: 29.5 Pts + Rebs + Asts

• Lillard has tallied at least 30 combined points, rebounds, and assists in five of his first seven games this year.
• In addition to Lillard scoring at least 20 points on five separate occasions, he had 21 points, 5 rebounds, and 4 assists against the Lakers on October 27.
• Los Angeles is permitting the sixth-highest 3-point rate (45.7%) and the 10th-highest 3-point percentage (35.8%).
• With Lillard averaging 6.6 free throw attempts, it’s worth noting that the Lakers are allowing the seventh-highest FT rate (32.0%).

Add Damian Lillard + Trail Blazers to cover the spread to your PrizePicks lineup now.

Make Trail Blazers vs. Lakers Picks on PrizePicks

The Trail Blazers and the Lakers are battling it out in an NBA Cup game in West Group C on Friday. With Luka Doncic playing at an MVP level and Portland having solid depth, this could be a high-scoring affair.

Don't wait until tip-off — make your Trail Blazers vs. Lakers picks on PrizePicks now!

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