NFL Week 15 is a crucial week as there are only a few weeks left for teams to jockey for playoff positioning, seeding, and make a statement; while other teams to tank for draft positioning.
This week, we get a ton of big-time games, including Bills vs. Patriots in the AFC and Lions vs. Rams in the NFC. But even in the games that aren't in the headlines, there are plenty of NFL Week 15 predictions to choose from — including Giants QB Jaxson Dart, Bengals WR Ja'Marr Chase, and Browns RB Quinshon Judkins.
The NFL cheat sheet is your ultimate resource for NFL Week 15 predictions and top player picks for PrizePicks NFL, including matchups to target and game insights for the Sunday main slate.
Ready to lock in your NFL Week 15 predictions? Just go to the PrizePicks NFL board, pick your players, and predict if they’ll have More or Less than their projected stats to win cash if you're right in NFL Week 15. Let's get into the top predictions and picks for this week.
NFL Week 15 Predictions & Cheat Sheet for PrizePicks, NFL DFS
Find the top Week 15 predictions, picks, matchups to target, and players to target in Sunday's games below in the PrizePicks Cheat Sheet, including analysis on QBs, RBs, WR vs. CB matchups, and OL vs. DL mismatches.
Best QB Predictions for NFL Week 15
Here are two of the top QB vs. defense matchups for fantasy football and PrizePicks NFL this week to help you make your NFL Week 15 predictions.
Giants QB Jaxson Dart vs. Commanders
Since Week 10, the Washington Commanders have been dead last in the NFL in dropback expected points added (EPA) allowed and also rank last in overall EPA per play, a direct result of injuries, inexperience, and a lack of consistent pass rush. The secondary has been especially vulnerable, ranking 28th in pass TDs allowed and 27th in pass yards allowed to opposing quarterbacks in 2025.
Even as just a rookie, Dart has been highly efficient. He has thrown for 1,500 yards and 11 TDs while posting a strong 9.3 average depth of target, one of the highest marks in the league. He's also limited mistakes with just 3 interceptions.
Dart adds a dangerous rushing element, ranking third among quarterbacks with 7 rushing TDs, giving him a high ceiling against a Commanders defense that struggled to contain Giants QB Russell Wilson (8 rushes, 44 yards) in Week 1 and explosive downfield throws.
Week 14 Prediction for PrizePicks: Jaxson Dart – 207.5 Passing Yards; 28.5 Rush Yards
Jaguars QB Trevor Lawrence vs. Jets
Since Week 10, the New York Jets rank 24th in dropback EPA allowed and 28th in overall EPA per play, signaling a defense that has steadily declined as the season has progressed.
They have also failed to generate pressure consistently, ranking 29th in the NFL in sack rate, which sets up a favorable pocket environment for opposing quarterbacks.
Jaguars QB Trevor Lawrence is quietly putting together one of the more productive seasons of his career under new head coach Liam Coen, ranking top 15 in passing yards (2,880) and top 15 in pass TDs (18). He has also been a legitimate threat on the ground, ranking fourth among QB with 5 rushing TDs.
The addition of Jacobi Meyers in the slot via trade has provided Lawrence with a reliable chain-mover, further stabilizing the offense. With likely ample time in the pocket and a Jets secondary that struggles in coverage, Lawrence is positioned for another strong passing performance this week.
Week 15 Prediction for PrizePicks: Trevor Lawrence – 223.5 Passing Yards
Best RB Predictions for NFL Week 15
Here are two of the top RB vs. defense matchups to target for fantasy football and PrizePicks NFL this week to help you make your NFL Week 15 predictions.
Commanders RB Chris Rodriguez Jr. vs. Giants
Since Week 10, the New York Giants have been the worst run defense in football. They are allowing an NFL-high 163.8 rushing yards per game and a league-worst 6.55 yards per carry.
The Giants have also allowed 5 rushing TDs over this stretch and rank second in yards before contact allowed (2.86), trailing only the Bears. Opposing running backs are routinely reaching the second level untouched.
Commanders RB Chris Rodriguez Jr. has quietly taken over as the lead back for Washington over the last three games. He has totaled 36 carries in that span and is averaging an impressive 4.6 yards per attempt, placing him inside the top 20 league-wide.
Even more encouraging, Rodriguez ranks seventh in yards after contact per carry (3.47), showing strong efficiency and power once engaged. On just 103 offensive snaps, he has already piled up over 370 rushing yards, making him one of the most efficient backs on a per-snap basis.
Week 15 Prediction for PrizePicks: Chris Rodriquez – 50.5 Rushing Yards
Browns RB Quinshon Judkins vs. Bears
Since Week 10, the Chicago Bears have been one of the most vulnerable run defenses in the NFL. They are allowing 5.15 yards per carry, the third-worst mark in the league, along with 134.8 rushing yards per game, which ranks ninth worst.
Chicago is also surrendering the most yards before contact in the NFL at 3.40, a clear sign they’re getting blown off the ball up front and are completely gassed on the ground.
Browns rookie RB Quinshon Judkins has stepped into a meaningful role for Cleveland and is seeing a steady workload. Over the last two games, Judkins has logged 37 carries, averaging 3.7 yards per carry, and already has seven rushing touchdowns despite playing in just 12 games.
His role has expanded near the goal line, where the Browns have leaned on wildcat looks, with Judkins functioning as the primary option. Against a Bears defense that can’t generate early contact, Judkins is set up for volume-driven production and touchdown equity.
Judkins has a few other aspects working in his favor. This game will be played in freezing temperatures, with "feels like" temperatures forecasted to reach -20°F. That could impact the Browns' passing game, especially with rookie QB Shedeur Sanders getting just his fourth start.
Additionally, the Browns will be without RB Dylan Sampson (calf, hand), who was ruled out on Friday, and RB Jerome Ford, who was placed on IR this week. Together, the two have played more than 58% of the Bears snaps this season. We could see Judkins see more than a 65% share of the snaps for the first time in his young career.
Week 15 Prediction for PrizePicks: Quinshon Judkins – 70.5 Rushing Yards
Best WR vs. CB Matchups to Target: Week 15
Here are two of the top WR vs. CB matchups to target for fantasy football and PrizePicks NFL this week to help you make your NFL Week 15 predictions.
Bengals WR Ja’Marr Chase vs. Ravens CB Marlon Humphrey
Bengals WR Tee Higgins has re-entered concussion protocol and will sit out in Week 15, which could funnel even more volume toward Ja’Marr Chase. Despite inconsistent quarterback play this season with QB Joe Burrow sidelined, Chase has still been elite, ranking second in the NFL in receptions (91) and second in receiving yards (1,015) while averaging 11.2 yards per catch.
Now, Chase has his QB back, and he faces a Ravens defense he has feasted on in recent AFC North matchups vs. the Ravens. In his last three games vs. the Ravens, Chase has averaged 9.3 receptions and 189 yards per game, including 7-110 (14 targets) on Thanksgiving.
The matchup is ideal for Chase. Ravens CB Marlon Humphrey has had a disastrous season in coverage, ranking 109th out of 109 corners, via PFF. When targeted, Humphrey is allowing a 100.0 passer rating, 14.2 yards per reception, and has already given up 46 receptions.
Baltimore has also struggled structurally, ranking near the bottom of the league in receptions allowed per game to opposing wide receivers. With Higgins likely out, Chase is set up for another high-volume, high-efficiency performance.
Week 15 Prediction for PrizePicks: Ja'Marr Chase - 93.5 Receiving Yards; 7.5 Receptions
Commanders WR Deebo Samuel vs. Giants CB Dru Phillips
Washington will be without TE Zach Ertz, who has been a reliable chain-mover and target vacuum, and his absence should directly benefit Deebo Samuel. Despite the quarterback carousel in Washington due to Jayden Danels' injury, Samuel has remained productive, ranking top 15 in receptions (62), top 20 in receiving TDs (5), and totaling 561 receiving yards this season.
When targeted, Deebo is providing quarterbacks with a 106.3 passer rating and is averaging 9.0 yards per reception on 7.2 targets per game.
He draws a favorable matchup against Giants slot CB Dru Phillips, who ranks 64th out of 109 corners in coverage via PFF. Phillips is allowing nearly a 100 passer rating, 10 yards per reception, and has surrendered 48 receptions, the fifth-most among secondary defenders this season.
With Ertz sidelined, Samuel is positioned for increased usage and a strong opportunity to exploit this matchup.
Week 15 Prediction for PrizePicks: Deebo Samuel – 4.5 Receptions
Best OL vs. DL Matchups to Target for NFL Week 15
Here are two of the top OL vs. DL matchups to target for fantasy football and PrizePicks NFL this week to help you make your NFL Week 15 predictions.
Texans DL vs. Cardinals OL
Houston’s defensive line is one of the most disruptive units in the NFL, led by DE Danielle Hunter and DE Will Anderson Jr. Hunter ranks sixth out of 112 defensive ends via PFF as a pass rusher and has posted 64 total pressures, which ranks fifth in the NFL, along with 12 sacks (fourth-most).
Anderson has been even more relentless, ranking fourth out of 104 edge defenders via PFF, piling up 76 pressures (second-most in the league) and 11 sacks, which ranks sixth. On the interior, DT Tommy Togiai has quietly been effective, recording 19 pressures and two sacks in just 163 pass-rush snaps, consistently collapsing the pocket from the middle.
Arizona’s offensive line is ill-equipped to handle that kind of pressure. RT Kelvin Beachum ranks 69th out of 81 tackles, per PFF, and has already allowed 28 pressures, 4 sacks, and drawn 5 penalties.
Cardinals RG Isaiah Adams has surrendered 18 pressures, 1 sack, and 6 penalties, while LG Evan Brown has struggled badly, allowing 35 pressures, 2 sacks, and 4 penalties.
Cardinals QB Jacoby Brissett has also not fared well vs. pressure, ranking 19th among NFL QBs with a 17.5% pressure-to-sack rate since taking over for Kyler Murray.
This matchup heavily favors Houston, especially in obvious passing situations where the Cardinals’ interior protection is most vulnerable.
Week 15 Prediction for PrizePicks: Cardinals QB Jacoby Brissett – 233.5 Pass Yards
Eagles DL vs. Raiders OL
Philadelphia’s defensive front continues to overwhelm opposing offensive lines; even without DT Jalen Carter, the Raiders OL could have their hands full.
Trade-deadline acquisition DE Jaelen Phillips has been a major boost, ranking ninth in the NFL with 59 total pressures and 16th out of 104 edge defenders, via PFF, as a pass rusher. Inside, DT Moro Ojomo has been a force, generating 42 pressures and adding 4 sacks, which ranks 17th among interior defensive linemen.
Even with injuries limiting his snaps, DE Nolan Smith has flashed elite efficiency, recording 23 pressures and 1 sack in just 149 pass-rush snaps.
Las Vegas’ offensive line has been a liability all season.
LT Stone Forsythe has been overwhelmed, allowing 33 pressures, 10 sacks, and 4 penalties. RT DJ Glaze has fared no better, surrendering 36 pressures, 7 sacks, and 5 penalties. C Alex Cappa has also struggled under pressure, giving up 19 pressures, 4 sacks, and 2 penalties from the middle.
With multiple weak points across the line, the Raiders are set up for a long day against Philadelphia’s deep and relentless pass rush.
Week 15 Prediction for PrizePicks: Raiders QB Kenny Pickett – 195.5 Passing Yards
Make NFL Week 15 Predictions on PrizePicks
The 2025 NFL season marches closer to the playoffs as we enter Week 15. These games just matter more, as more teams will be closer to clinching their playoff spot or eliminated this week.
Sunday brings you yet another opportunity to win real money on PrizePicks with your NFL predictions. Use this NFL Week 15 Cheat Sheet and predictions to sharpen your takes and build out your winning picks for Sunday's Week 15 slate.
PrizePicks is the simplest way to make your NFL predictions and win real money if you're right all season long. Pull up the PrizePicks NFL board, pick at least two players, predict More or Less on their projections — like yards or receptions — and win real money when you’re right.
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