NFL DFS Cheat Sheet for PrizePicks: Week 18
We get a full 14-game slate of NFL games on Sunday for Week 18, with most games involving teams still needing wins to secure their Playoff spot.
Below in the PrizePicks Cheat Sheet for Sunday, we’ve got the top NFL DFS picks for the Sunday NFL Week 18 games for PrizePicks, including the best matchups to target for NFL DFS in these games.
Check the PrizePicks NFL board now, lock in your picks, and get in on all of the Week 18 Sunday NFL action. It’s the easiest way to cash in on your NFL knowledge, all the way through the 2025 Super Bowl.
NFL DFS Cheat Sheet for PrizePicks: Week 18
Find the top NFL DFS picks, matchups to target, and TD scorer predictions for Week 18 below in the PrizePicks Cheat Sheet.
- Week 18 Best OL/DL Matchups to Target
- Week 18 WR/CB Matchups to Target
- Week 18 Best TD Scorer Picks
- Player Contract Incentives
- Teams Resting Starters in Week 18
- Week 18 Playoff-Clinching Scenarios
Best OL/DL Matchups to Target: Week 18
Eagles DL vs. Giants OL
The Giants offensive line is by far one of the worst units in the NFL. LT Jermaine Eluemunor has allowed nine QB hits and 20 pressures this season, ranking 52nd out of 78 tackles. Meanwhile, RT Evan Neal sits 73rd out of 79 tackles in pass blocking, allowing 17 pressures and committing six penalties in the 2024 season.
The Giants will also be without starting center John Michael Schmitz Jr., who is crucial for directing blocking schemes. Despite resting some starters, the Eagles still feature a defensive line led by former first-round pick Nolan Smith — who ranks 11th out of 114 defensive ends at rushing the passer — and third-round pick Jalyx Hunt, who ranks 40th out of 114 in the same category. In the middle is DT Milton Williams, ranking 23rd out of 125 interior defensive linemen this season and top five in run-stuffing.
PrizePicks Pick: Giants RB Tyrone Tracy Jr. 51.5 Rush Yards — Less
Seahawks OL vs. Rams DL
The Seattle Seahawks offensive line has been notably disappointing this season. RT Stone Forsythe ranks 79th out of 79 tackles in pass blocking, making him the NFL’s worst pass-blocking right tackle. At right guard, Sataoa Laumea sits 75th out of 75 guards, placing him at the bottom of the league at his position. Meanwhile, center Olu Oluwatimi ranks 30th out of 41 centers.
On the other side, the Rams feature a pair of emerging pass rushers: first-round pick Jared Verse, who already ranks inside the top 10 in pass-rush metrics during his rookie year, and third-round pick Kobe Turner, who is 14th out of 125 interior defensive linemen.
With the Seahawks’ right side particularly vulnerable, Verse and Turner could wreak havoc in this matchup.
PrizePicks Pick: Seahawks QB Geno Smith 242.5 Pass Yards — Less
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Best WR/CB Matchups to Target: Week 18
Packers WR Romeo Doubs vs. Bears CB Tyrique Stevenson
Chicago Bears CB Tyrique Stevenson ranks 88th out of 117 cornerbacks in coverage, making him a bottom-tier option. When targeted, he’s allowing a near 100 passer rating and over 13 yards per reception, having surrendered 41 receptions on the season, which is 39th in the NFL. Lined up against him will be Packers wide receiver Romeo Doubs, who has 600 yards this year on 46 receptions with a 99 passer rating — showing a serviceable connection with QB Jordan Love.
Giants WR Malik Nabers vs. Eagles CB Isaiah Rodgers
The Eagles will be resting key starters in what is essentially a meaningless game against the New York Giants, making wide receiver Malik Nabers — who is having a spectacular rookie season — an appealing option for NFL DFS.
Nabers ranks top 10 in targets, receptions, and receiving yards despite this being his first year in the NFL. When targeted, he boasts an impressive near 100 passer rating. Slated to be across from him is CB Isaiah Rodgers, who has had limited playing time this season and is coming off a year-long suspension. Rodgers allows a 90+ passer rating and has been one of the weaker links in the Philadelphia Eagles secondary.
Best TD Scorer Picks for Week 18
Find more TD scorer predictions for Week 18 here.
Chargers WR Ladd McConkey vs. Raiders (Demon)
Chargers QB Justin Herbert is enjoying an outstanding season, demonstrating excellent ball security and efficiency under center. By contrast, Raiders CB Decamerion Richardson (ranked 116th out of 117 cornerbacks on PFF) has struggled in coverage, allowing a passer rating over 100 when targeted.
He is slated to face rookie WR Ladd McConkey, who ranks inside the top 15 in receiving yards and touchdowns, and is near the top in receptions. When targeted, McConkey boasts a 125 passer rating, making him one of the league’s most dangerous young receivers and a prime threat against the Raiders’ horrible secondary.
Note: Demon picks add a payout boost to your lineup on PrizePicks, as they are more difficult projections to hit.
Falcons WR Drake London vs. Panthers (Demon)
Panthers CB Dean Jackson ranks among the worst in coverage this season, allowing a passer rating of nearly 120 with over 10 yards per reception in his limited playing time, per PFF. This easily makes him one of the worst slot cornerbacks in the NFL. Slated to be across from him is Falcons wide receiver Drake London, who’s having a spectacular season.
When targeted, London owns a near 100 passer rating and ranks top 10 in receptions, receiving yards, and targets among wide receivers. The Falcons are in a must-win spot, and London looked in-sync with QB Michael Penix Jr. last week, with 13 targets for 106 yards and a touchdown.
Note: Demon picks add a payout boost to your lineup on PrizePicks, as they are more difficult projections to hit.
Lock in for Week 18 NFL DFS on PrizePicks
Week 18 brings us a NFL DFS slate loaded with exciting matchups with division titles and playoff positioning on the line. Use the PrizePicks NFL Cheat Sheet to sharpen your takes and build out your winning Lineups for the Week 18 Sunday NFL slate.
PrizePicks is the simplest way to play NFL daily fantasy sports all season, even through the NFL Playoffs and the 2025 Super Bowl. Visit the PrizePicks NFL board, pick at least two player projections — like yards or touchdowns — and lock in your Lineup.
Keep it dialed in on the Playbook for more PrizePicks picks and predictions for NFL DFS and fantasy football all season long.
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