The Chargers and Rams are set to battle in their home stadium at 4:05 p.m. ET on FOX. The Rams are looking to get to .500 and grab consecutive wins for the first time this season, while the Chargers seek their first win as their campaign quickly plummets.
Over on PrizePicks, the Rams are 6.5-point home favorites on the spread.
Below, we’ll break down our Chargers vs. Rams prediction and picks for NFL Week 8, including the spread, over/under, and top player picks for PrizePicks.
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Chargers vs. Rams Prediction, Spread, Over/Under for Week 8 – Sunday, November 1
The Rams are a 6.5-point home favorite over the Chargers, per PrizePicks, returning a 1.29x payout with a Week 8 victory.
Here are the full payouts for the Chargers vs. Rams on PrizePicks, including winner payouts, the spread, and the over/under. PrizePicks data is live at the time of writing and is subject to change.
Make your Chargers vs. Rams prediction on the spread on PrizePicks.
All stats are via NFL Next Gen Stats, FTN Fantasy, and PFF unless otherwise noted.
The Rams have a lot of ground to make up after a rough start. They are currently 3-4, but the 49ers lead them by three games in the NFC West. The good news is that, including today, they have three straight games against teams with losing records.
Injuries have played a major role in the Rams’ struggles. Their biggest acquisition, EDGE Myles Garrett, had a brief debut before suffering a knee injury in Week 1 and going on IR.
The defense has dealt with multiple injuries. CB Trent McDuffie has a groin issue that's kept him out of the last two games, but his return to practice this week is encouraging. LB Nate Landman missed Week 7 with a concussion but has also returned to practice.
L.A. also suffered significant injuries to the WR room. Puka Nacua missed two games due to a groin injury, and WR Davante Adams could miss the next two months with a ruptured hamstring.
Reigning MVP QB Matthew Stafford still has great command of the offense, leading the league in passing yards (1,989) entering Week 8. Still, the Rams may need to balance the run and pass while making some defensive stops to win this matchup.
The Chargers might keep Stafford quiet, as they rank ninth in passing yards allowed per game (206.2). Unfortunately, they don't have much else to help remain competitive.
The defense ranks 22nd in PPG (25.2), and the offense has struggled all year long. The Chargers score the fewest PPG (15.0), largely because they can't throw the ball. Justin Herbert has been one of the league’s worst QBs, ranking 28th in completion rate (59.4%) and 33rd in EPA per dropback (-0.24).
Los Angeles brought in offensive coordinator Mike McDaniel to elevate an offense that fell short of expectations last year, but with how much it’s regressed, McDaniel may not have this job much longer with another poor performance.
Chargers vs. Rams Prediction on Spread – 11/1/26
Here are the key stats and predictions behind our Chargers vs. Rams pick against the spread for Sunday, November 1.
- According to RBSDM, the Chargers have the league's least productive offense and rank last in EPA per play (-0.20). The Rams' defense is seventh in EPA/play allowed (-0.04).
- The Chargers struggle in the red zone, sitting just 23rd in conversion rate (50.0%). The Rams are exceptional at preventing opponents from scoring there, ranking fifth in conversion rate allowed (44.4%).
- The Rams are only 26th in takeaways per game (0.9). However, the Chargers have the most giveaways per game (2.5).
- Head coach Sean McVay's group is excellent at forcing quick offensive possessions, ranking seventh in opposing three-and-out rate (22.7%).
- The Chargers' pass protection has failed them, sitting 26th in sacks allowed (21) and 30th in pressure rate allowed (26.7%). Even though the Rams only rank 27th in sacks (11), they might find success. In the Chargers’ Week 6 loss to the Chiefs, Kansas City recorded 4 sacks. The Chiefs are 29th in total sacks (8).
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Chargers vs. Rams Picks, Player Stats for PrizePicks: 11/1/26
Here are the top Chargers vs. Rams picks to target on Sunday, November 1. Today’s NFL picks for PrizePicks include RB Kyren Williams and QB Justin Herbert.
Rams RB Kyren Williams vs. Chargers: 59.5 Rush Yards
- After rushing for only 99 combined yards in Weeks 5 and 6, Williams rebounded with 99 rushing yards in Week 7 against the Raiders, who rank 31st in rushing YPG allowed (143.6). This is another favorable matchup for Williams against the Chargers, who rank 21st in rushing yards allowed per game (123.8).
- Williams has handled a heavy load, getting 15 or more carries in four of his last five games. Los Angeles sees the fifth-most carries per game (30.8) from opponents.
- Williams excels against a stacked box of 8+ defenders, ranking third in the league in YPC (5.1). The Chargers are 21st in YPC ceded when playing with a stacked box (2.8).
- The Rams' star RB has the third-lowest stuffed run rate among qualified running backs (10.4%). The Chargers rank only 17th in run stuff rate (20.2%).
Add Kyren Williams + Rams to win to your PrizePicks lineup now.
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Chargers QB Justin Herbert vs. Rams: 23.5 Rush Yards
- According to CBS Sports, the Rams are allowing the fifth-highest YPC to QBs (5.9).
- When Herbert is under pressure, he can take off and use his legs for a positive play. He's fourth in the league in scrambles (19) and eighth in scramble yards (129).
- Herbert can be tough to bring down, evidenced by his 8 missed tackles forced, ranking third among QBs. The Rams rank 19th in missed tackles (38).
- The Chargers signal-caller routinely fights for extra yards, leading all QBs in YPC after contact (5.3).
Add Justin Herbert + Chargers to cover the spread to your PrizePicks lineup now.
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The Rams were the favorite to win the Super Bowl at the start of the season, but after a rough start, they have to get back in the playoff picture. The Chargers' season has been a disaster, and they could make swift changes if they don't start winning.
Don't wait until kickoff — make your Chargers vs. Rams picks on PrizePicks now for Week 8 and earn real money if you're right.
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