On this Thanksgiving Eve, we are thankful for the NBA, which is giving us a full slate of NBA Cup games. There are nine matchups to look forward to, including a key Western Conference matchup between the Minnesota Timberwolves (10-7) and Oklahoma City Thunder (17-1) at 7:30 p.m. ET on ESPN.
We'll break down our Timberwolves vs. Thunder prediction and PrizePicks NBA picks for Wednesday night below, including picks for star guards Shai Gilgeous-Alexander and Anthony Edwards picks as they go head-to-head.
This will be the first time these teams square off since the 2025 Western Conference Finals, when the Thunder cruised to a 4-1 series win on its way to the NBA title. The defending champs are off to an incredible start in 2025-26, as they are sitting in a familiar spot atop the Western Conference standings.
The Timberwolves are coming off back-to-back losses, including one against the Suns in NBA Cup group play.
Let's get into our Timberwolves vs. Thunder prediction and picks for Wednesday night.
Timberwolves vs. Thunder Spread, Over/Under
The Timberwolves enter this NBA Cup game as significant 10.5-point underdogs, returning a 3.7x payout on PrizePicks Team Picks if they win outright vs. the Western Conference's best.
The Thunder are home favorites with a 1.23x payout if they win outright. All data via PrizePicks Team Picks.
- Spread: Oklahoma City Thunder -10.5 (2.12x payout)
- Total: 226.5
- Game Winner Payout: MIN Timberwolves 3.7x | OKC Thunder 1.23x
Timberwolves vs. Thunder Prediction, Preview for Wednesday, Nov. 26
Let’s break down this Timberwolves vs. Thunder game in a rematch of the Western Conference Finals on Wednesday, November 26, on ESPN.
Thunder Preview vs. Timberwolves
- There is no championship hangover for the Thunder as they hold a league-best 17-1 record.
- Oklahoma City had to go through the Timberwolves in last year’s playoffs — the Thunder won in five games.
- OKC dominated that series, winning the four games by an average of 18.2 points.
- It’s hard to identify a weakness in this team, because they perform well on both sides of the court. Oklahoma City leads the league in adjusted net rating (+10.9).
- The Thunder are one of only two teams in the top four in both adjusted offensive and defensive ratings.
- Each of OKC's last 12 wins have been by at least 10 points; the Thunder's average scoring margin is +16.9.
Timberwolves Preview vs. Thunder
- Minnesota was embarrassed in the Western Conference Finals by OKC, but its struggles against them extend to the regular season. The Thunder holds a lifetime record of 92-48 against the Timberwolves.
- Minnesota is coming into this game on a slide, having lost two straight, including against the 5-13 Kings.
- The Timberwolves' offense runs through SG Anthony Edwards, especially recently, as his 20.5 field goal attempts per game since November 1 is seventh in the NBA.
- After struggling early in the season, the Wolves' defense is improving. In October, Minnesota ranked 27th in defensive rating (119.5). Since November 1, their 109.2 defensive rating ranks third in the NBA.
Timberwolves vs. Thunder Picks for PrizePicks – 11/26/25
Below are three top Timberwolves vs. Thunder picks for PrizePicks NBA on Wednesday. On PrizePicks NBA Player Picks game, just pick your players, predict More or Less on their stats, and win real money if your picks are correct.
Thunder PG Shai Gilgeous-Alexander vs. Timberwolves Projection – 31.5 Points
- NOTE: SGA is questionable to play vs. the Timberwolves with an illness; check final injury reports before making your picks.
- The reigning MVP is off to a great start in 2025-26, ranking third in points per game at 32.2.
- SGA is one of the top scorers in November, ranking third in the league with 31.1 points per game.
- Gilgeous-Alexander has a history of success against Minnesota, scoring 31+ points in six of his last nine games.
- Minnesota ranks third in defensive efficiency at home (1.055) compared to 13th on the road (1.121) — a significant decrease.
- SGA’s 34.4 true shot attempts per 100 possessions is in the 100th percentile.
- The T-Wolves rank 18th in opponents’ attempted field goals per game (88.9).
- SGA scored 34+ points in three of five WCF games last year, and 30+ in four of five.
Timberwolves SG Anthony Edwards vs. Thunder Projection – 25.5 Points
- Anthony Edwards may have a chip on his shoulder, as he will face the Thunder for the first time since the WCF loss, which was followed by shots fired directly at Ant by SGA's camp at Converse (above).
- Edwards is averaging 27.8 points per game, which ranks 13th in the league.
- Ant Man has spent a lot of time on the court recently, playing 40 minutes in back-to-back games.
- As a result of this playing time, Edwards has scored 40+ points in his last two games.
- One of those two games went to OT, while the other finished in a 1-point loss; if this game can stay close, Edwards could see similar minutes.
- In two of the last three games vs. the Thunder where the T-Wolves did not lose by 20+ points, Ant scored 30+ points.
- Including the playoffs, the 2020 No. 1 overall pick has played 39+ minutes in five of his previous eight games against the Thunder.
- Edwards put up 20+ shots in only two of nine games vs. the Thunder last year; he's averaging 19.8 shots per game this year.
Timberwolves C Rudy Gobert vs. Thunder Projection – 10 Rebounds
- Gobert has topped his rebounds projection in 8-of-17 games this season.
- He has three consecutive games with double-digit rebounds.
- The two-time NBA Defensive Player Of The Year is averaging 11.0 rebounds per game in November, which ranks ninth.
- Gobert is one of the best at boxing out on field goal attempts, ranking fifth in the league with 3.1.
- That's key to helping him pick up boards, as his 2.1 rebounds on box outs are sixth in the league.
- Gobert did not record 10 rebounds in six games vs. OKC last season, but he recorded 9 rebounds twice in the WCF.
Make Wednesday NBA Picks on PrizePicks
On Wednesday, the NBA offers a nine-game slate featuring some excellent NBA Cup matchups. One of the top matchups features SGA and the defending champion Thunder hosting Anthony Edwards and the Timberwolves, who will be looking for revenge.
In this Western Conference matchup, there are plenty of spots to make your NBA picks on PrizePicks. Just predict More or Less on NBA player projections — like SGA's points — and win money if you're right.
Check out the Playbook for more PrizePicks NBA picks and analysis all the way through the 2025-26 season and NBA Cup.
