The Los Angeles Dodgers vs. Houston Astros game is set for a first pitch at 8:10 p.m. ET on Monday, May 4, with the Dodgers returning a 1.44x payout with a win, via PrizePicks.
The Dodgers continue their road swing after avoiding a sweep in St. Louis against the Cardinals. Los Angeles snapped a four-game slide in Sunday’s 4-1 victory to remain atop the National League West at 21-13.
The Astros return home following a series victory at the Boston Red Sox, winning the final two games. Houston improved to 14-21 but still sits in fourth place in the American League West.
Below, we'll break down our Dodgers vs. Astros prediction and picks for Monday's MLB game, including the winner, over/under, and key player picks for PrizePicks.
Make your picks for Dodgers vs. Astros on PrizePicks now.
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Dodgers vs. Astros Prediction, Winner Payout, Over/Under – Monday, May 4
The Dodgers hit the skids recently, dropping two games at home to the Miami Marlins before losing the first two in St. Louis. The offense scored 2 or fewer runs in those four losses but rebounded with 4 runs on 10 hits in Sunday’s victory.
Los Angeles is winless in four of the last five series while losing three of its past four series openers.
The Astros haven’t been much better in Game 1 of series, posting a 3-8 mark. With that said, Houston seeks its first three-game winning streak since capturing five straight to close out March.
Tonight is the first time this season the Astros are starting an opener (Steven Okert), and the Dodgers are facing an opener for the first time.
Last season, Houston swept Los Angeles at Dodger Stadium, highlighted by an 18-1 blowout in the opener. The Astros have won six of the last seven matchups with the Dodgers since 2023.
Dodgers vs. Astros Winner Payout, Over/Under – Monday, May 4
The Dodgers enter Monday’s game as road favorites against the Astros, returning a 1.44x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Dodgers vs. Astros game on PrizePicks.
- Spread: Los Angeles Dodgers -1.5 (1.75x payout)
- Over/Under: 8.5 (1.78x payout on Over)
- Game Winner Payout: Dodgers 1.44x | Astros 2.56x
Play the Dodgers vs. Astros winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live at the time of writing and is subject to change.
Dodgers vs. Astros Prediction on Over/Under – 5/4/26
Here are the key game stats and trends behind our Dodgers vs. Astros prediction on the over/under for Monday, May 4.
Lock in your Dodgers vs. Astros prediction on PrizePicks before the line moves.
- The Astros have allowed the most runs in baseball at 201. Houston has given up 47 runs in its past six home contests.
- Los Angeles ace Yoshinobu Yamamoto makes his first career start against Houston. He's allowed a .257 xBA and .418 xSLG this year after seeing those numbers be .198 and .304, respectively, in 2025.
- The Astros own the highest BA (.316) and are fifth in wOBA (.359) over the last seven days.
- The Dodgers and their opponents have combined for at least 9 runs in each of the past three series openers.
- Houston has hit the over in 12 of their last 14 home games. In 11 of those contests, the Astros and their opponent totaled more than 10 runs.
Dodgers vs. Astros Player Picks, Stats for PrizePicks: 5/4/26
Here are top Dodgers vs. Astros picks to target on PrizePicks for Monday, May 4. Today’s MLB picks for PrizePicks include 1B Christian Walker and DH Shohei Ohtani.
Astros 1B Christian Walker vs. Dodgers Projection: 4.5 Hitter Fantasy Score
- Walker is one of two Astros to play in all 35 games this season (DH Yordan Alvarez is the other).
- He's recorded at least 1 hit in nine of the last 10 games and has six multi-hit outings in this stretch.
- Walker has eclipsed this fantasy score in four straight games, highlighted by 26 points in Saturday’s win at Boston.
- The former Arizona Diamondback homered in each of his last two home games and has picked up more than 5 points in four straight contests at Daikin Park.
Add Christian Walker to your PrizePicks Lineup now.
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Dodgers DH Shohei Ohtani vs. Astros Projection: 0.5 Walks
- Ohtani owns a career-best walk rate of 15.5%, ranking in the 89th percentile of MLB.
- Houston’s pitching staff posts the highest BB/9 rate at 5.51, a major drop from last year's 3.17 mark.
- Only 6 of Ohtani’s 24 walks have come away from Dodger Stadium. In 2025, 54% of his walks occurred on the road.
- The Astros are likely going through a committee of pitchers tonight. LHP Steven Okert, the opener, has dealt 6 walks in 15 innings of work.
Add Shohei Ohtani to your PrizePicks Lineup now.
Make Dodgers vs. Astros Picks on PrizePicks
The Dodgers ended their losing streak on Sunday, as their offense made progress against the Cardinals. Can Los Angeles take advantage of Houston’s pitching woes in tonight’s interleague opener?
Don’t wait until lock — make your Dodgers vs. Astros picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.
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