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Week 6 is the first week of the 2026 NFL season where at least four teams are on a bye, making it even more difficult to make fantasy football lineup choices. In addition to navigating bye weeks, managers must stay updated on injury news to make the best start ‘em, sit ‘em decisions.
If you tend to stress over lineup decisions or wait until the last minute, look no further than our Week 6 fantasy football rankings.
Below, we’ll highlight the best fantasy football options at each position in Week 6, including quarterbacks, running backs, wide receivers, tight ends, and defense/special teams.
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All fantasy football rankings below use PrizePicks NFL fantasy scoring, which includes one point per reception (PPR). Players who historically catch more passes should get a slight discount if you are in non-PPR leagues.
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Week 6 Quarterback Rankings
Here are our Week 6 quarterback rankings for the 2026 fantasy football season.
Make NFL Week 6 predictions on PrizePicks — including pass yards and TDs!
Week 6 Running Back Rankings
Here are our Week 6 running back rankings for the 2026 fantasy football season.
Make NFL Week 6 predictions on PrizePicks — including rush yards and TDs!
Week 6 Wide Receiver Rankings
Here are our Week 6 wide receiver rankings for the 2026 fantasy football season.
Make NFL Week 6 predictions on PrizePicks — including receiving yards and TDs!
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Week 6 Tight End Rankings
Here are our Week 6 tight end rankings for the 2026 fantasy football season.
Make NFL Week 6 predictions on PrizePicks — including receiving yards and TDs!
Week 6 Defense/Special Teams Rankings
Here are our Week 6 defense and special teams rankings for the 2026 fantasy football season.
Make NFL Week 6 predictions on PrizePicks — including sacks and teams to win!
Make 2026 NFL Predictions on PrizePicks
Ahead of this week’s NFL games, notable injury news to monitor includes QBs Lamar Jackson, Caleb Williams, and Michael Penix Jr. and RBs like TreVeyon Henderson and Jeremiyah Love.
Elsewhere, WRs such as CeeDee Lamb, Deebo Samuel, and others should be monitored. With Week 6 of the season set to kick off, which players should you insert in your fantasy football lineups? Don’t wait — make your 2026 NFL picks on PrizePicks now and earn real money if you’re right.
Once games start, just pick NFL players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on NFL game winners, spreads, over/unders, and award futures, now available in 36 states.
Stay locked in on Playbook for NFL predictions, picks, and news every day all the way through Super Bowl LXI.
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