College football is now in Week 4; this is the time when the season gets tough, as we get into conference play. Most of the Power Four teams move on from the softer schedule and play conference games that mean more for the Playoff seeding.
Below, we'll break down the top picks across Saturday's college football DFS slate for Week 4, including the top picks at QB, RB, and WR for PrizePicks real money CFB DFS game.
Several of the players featured this week are either facing a conference opponent or another Power Four program, including QB John Mateer’s first SEC conference matchup as No. 11 Oklahoma battles No. 22 Auburn at 3:30 p.m. ET on ABC.
There is another ranked matchup to start the day, with with No. 17 Texas Texas visiting No. 16 Utah at 12 p.m. ET on FOX, which could be a high-scoring contest, as both teams rank in the top 25 in points scored.
🏈 Play $5, Get $50 instantly in Lineups for CFB! Use PrizePicks Promo Code: PLAYBOOK
PrizePicks is the simplest way to win real money with your CFB picks every week; just pick your players, predict More or Less on their weekly stats, and cash in when your picks are correct.
Miami QB Carson Beck Projection: 272.5 Passing Yards
Florida vs. No. 4 Miami Pick – 7:30 p.m. ET
- Miami QB Carson Beck leads the FBS with a 79.3% completion rate.
- Beck has previously played two games against Florida as the quarterback for Georgia. He has beaten the Gators both times and thrown for over 300 yards in each.
- Beck’s offensive line is providing him a clean pocket on 87.2% of his dropbacks.
- In two career games against Florida, Beck is 41/55 (74.5%) with 541 yards and 4 TDs when he has a clean pocket.
- Florida is 122nd in sack percentage (1.56%).
- Miami is 34th in passing yards per completion (12.8).
- Florida is 103rd in passing yards allowed per completion (12.7).
Oklahoma QB John Mateer Projection: 259.5 Passing Yards
No. 22 Auburn vs. No. 13 Oklahoma Pick – 3:30 p.m. ET
- Oklahoma QB John Mateer has more than 253 passing yards in all three games this season.
- Mateer is seventh in the nation in passing yards (944).
- Mateer excels at the intermediate passes (10-19 yards) and leads the FBS in passing yards from that range (341), and the fifth-most first downs (17).
- In their only matchup against an FBS program, Auburn allowed 13 completions on intermediate throws in their Week 1 matchup against Baylor.
- Baylor QB Sawyer Robinson threw for 419 yards in Week 1 against Auburn, the most the Tigers have allowed since 2016.
- Auburn has allowed 10 passes of 20+ yards, eighth-most in college football.
Tennessee QB Joey Aguilar Projection: 278.5 Passing Yards
UAB vs. No. 15 Tennessee Pick – 12:45 p.m. ET
- Tennessee QB Joey Aguilar is sixth in the nation by averaging 320.0 passing yards per game.
- Aguilar threw for 371 yards last week against Georgia, tying NFL Hall of Famer and former Tennessee QB Peyton Manning for the most passing yards by a Volunteer in a game against the Bulldogs.
- Aguilar is second in the FBS in completion percentage (69.2%) on deep passes (balls thrown 20+ yards) and third in passing yards (369).
- UAB is last in the FBS in passing yards allowed per completion (18.0).
- UAB has allowed the seventh-most completions of 20+ yards (11).
- In Week 2, UAB allowed 168 passing yards to Navy, who is 125th in passing yards per game (131.0). Navy also had a season-high 225 passing yards in their meeting last year against UAB.
- In four games following a loss to Georgia, Tennessee head coach Josh Heupel has run up the score vs. inferior opponents, averaging 57.5 points per game vs. teams like UTEP (2024) and South Alabama (2021).
- In those games, Tennessee QBs have averaged 305 yards passing, including a 209-yard dud from Nico Iamaleava in 2024.
🏈 Play $5, Get $50 instantly in Lineups for CFB Week 4! Use PrizePicks Promo Code: PLAYBOOK
Miami WR Malachi Toney Projection: 24.5 Longest Reception
Florida vs. No. 4 Miami Pick – 7:30 p.m. ET
- Miami WR Malachi Toney leads the team in receptions (18), receiving yards (228), and receiving touchdowns (4).
- Toney has a 20+ yard reception in each game this season.
- He lines up in the slot on 90.8% of offensive plays and is 11th in the FBS in yards after catch when lined up in the slot (120) and second in first downs (12).
- Florida S Sharif Denson is the primary defender against slot receivers. His assignments average 6.5 yards after the catch.
- Toney is averaging 6.7 yards after the catch.
Texas Tech WR Coy Eakin Projection: 45.5 Receiving Yards
No. 17 Texas Tech vs. No. 16 Utah Pick – 12 p.m. ET
- Texas Tech WR Coy Eakin is leading the team with 229 receiving yards.
- Eakin is eighth in the FBS in yards per catch when lined up as a slot receiver (20.4).
- Eakin has 105 yards after the catch on 12 receptions when lined up as a slot receiver. Only four other players in the FBS have more yards with fewer receptions.
- Utah CB Jackson Bennee primarily lines up against slot receivers. He’s allowed 60 yards after the catch this season, the 16th-most in the FBS, per PFF.
Oklahoma WR Deion Burks Projection: 65.5 Receiving Yards
No. 22 Auburn vs. No. 13 Oklahoma Pick – 3:30 p.m. ET
- Oklahoma WR Deion Burks leads the team with 17 catches, 225 receiving yards, and 2 receiving TDs.
- In Oklahoma’s only other matchup against a Power Four opponent this season (Michigan), Burks caught 4-of-8 passes for at least 15 yards.
- Auburn is tied for 91st in 20+ yard receptions allowed (10)
- Burks will line up against Auburn CB Jay Crawford, who has allowed 12.3 yards per reception this season, per PFF.
Missouri RB Ahmad Hardy Projection:
South Carolina vs. No. 23 Missouri Pick – 7 p.m. ET
- Missouri RB Ahmad Hardy is leading the FBS with 28 missed tackles forced and second with 462 rushing yards, per PFF.
- Hardy’s 8.1 yards per carry is second amongst running backs with a minimum of 40 carries.
- Hardy is second in the FBS with six carries of 20 yards or more.
- His 250 rushing yards last week against Louisiana marked the seventh-highest single-game total in Missouri history.
- South Carolina is 96th in the FBS in rush rate over expected (4.8%).
- Former NFL head coach Jon Gruden recently praised Hardy, calling his running style “vicious” and said, “I love watching him run.”
Miami RB Mark Fletcher Jr. Projection: 75.5 Rushing Yards
Florida vs. No. 4 Miami Pick – 7:30 p.m. ET
- Miami RB Mark Fletcher Jr. leads all Miami running backs in snaps (46); however, RB CharMar Brown has only 12 fewer snaps in a closely split backfield.
- Florida is 31st in rush rate over expected (-5.6%).
- In Miami’s 41-17 victory over Florida last season, the Hurricanes led by at least 14 points throughout the entire second half, yet still passed the ball (36 pass attempts) more often than they ran it (33 carries).
- The majority of Fletcher Jr.’s runs are up the middle to the right of the center (MR). That is where Florida EDGE George Gumbs Jr. lines up and is fifth in PFF run defense grade (90.4).
Make Week 4 CFB DFS Picks on PrizePicks
This is when college football starts to get exciting, as most teams are beginning their conference schedule.
Whether you're watching a Big 12 matchup of Texas Tech vs. Utah or an SEC battle between Auburn vs. Oklahoma, PrizePicks is the best way to cash in on your college football takes.
Just pick your players — including John Mateer and Carson Beck, predict More or Less on their stat projections, and get paid when your picks are right in the PrizePicks CFB DFS game.
Stay locked in on the Playbook for more CFB DFS picks and college football predictions throughout the 2025 season.
