Don’t call it a comeback, but Florida State’s disastrous 2024 season might have just been a one-time thing.
Coming into their Friday night matchup vs. Virginia, the Seminoles' three wins already exceed last year’s total. Florida State QB Tommy Castellanos is reinvigorating this offense thanks to his dual-threat ability, even being mentioned as a Heisman candidate.
Castellanos highlights the top CFB DFS picks for Friday night's three-game college football slate to kickoff Week 5. Below, we'll highlight the best CFB DFS picks and PrizePicks picks today.
Also in Friday's college football slate, the reigning Big 12 champion Arizona State faces an early test vs. No. 24 TCU. TCU QB Josh Hoover has carried over his phenomenal 2024 season and has already thrown for 1,000 yards and 11 TDs in only three games.
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Finally, Oregon State looks to secure its first win of the season vs. Houston. Houston is looking better than last season, and a fourth win tonight would tie its win total from 2024.
Make your Friday CFB picks on PrizePicks before the action gets started at 7 p.m. ET; pick your players, predict More or Less on their stats, and win cash when you're right.
Friday CFB DFS Picks Tonight — Sept. 25
Here are the top Friday CFB DFS picks for Week 5 of college football on Friday, September 25, on PrizePicks, including Florida State vs. Virgnia and TCU vs. Arizona State.
Use this analysis to build your PrizePicks CFB Lineups for Friday's games.
Florida State QB Tommy Castellanos Projection: 172.5 Passing Yards
Florida State vs. Virginia Pick – 7 p.m. ET
- Florida State QB Tommy Castellanos is 16th in FBS in completion percentage this season (71.1%).
- Virginia has allowed over 250 passing yards to both Power Four opponents it hasfaced this year.
- In 2024, as the quarterback for Boston College, Castellanos threw for a season-high 254 yards, in addition to 3 TDs against Virginia.
- Virginia has allowed 9 completions of 20+ yards against Power Four opponents (T-103rd).
- Florida State is 24th in sacks allowed per game (1.0).
- Of Virginia’s 9 sacks this season, 5 came in the game against Stanford.
- Virginia has not recorded an interception in three straight games.
Arizona State RB Raleek Brown Projection: 58.5 Rushing Yards
TCU vs. Arizona State Pick – 9 p.m. ET
- Arizona State RB Raleek Brown is 18th in the FBS with 372 rushing yards.
- In Weeks 2-4, his 8.3 yards per carry were seventh in the FBS.
- Brown has the seventh-most carries of 10+ yards (8).
- Brown’s 25 forced missed tackles are the fifth-most in the FBS.
- Of the 10 TCU defenders with the most defensive snaps, eight have at least 2 missed tackles this season.
- TCU is 13th in rushing yards allowed per game, but the Horned Frogs have not faced an FBS opponent that ranks in the top 70 in rushing yards per game.
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TCU QB Josh Hoover Projection: 286.5 Passing Yards
TCU vs. Arizona State Pick - 9 p.m. ET
- Of the 25 quarterbacks who have thrown for 1,000 yards this season, TCU QB Josh Hoover has the third-highest yards per completion (9.7).
- Hoover has the eighth-most completions of 20+ yards (15).
- Arizona State is tied for 68th in 20+ yard completions allowed to Power Four opponents (6).
- TCU is 20th in offensive plays per game (75.5).
- According to PFF, Arizona State is 78th in pass rush grade (68.9).
- According to PFF, TCU is 40th in pass blocking grade.
Houston RB Dean Connors Projection: 73.5 Rushing Yards
Houston vs. Oregon State Pick – 10:30 p.m. ET
- Houston RB Dean Connors has averaged 110.5 yards over his last two games.
- In Weeks 2-3, Connors was 17th in rushing yards (221) and 18th in yards after contact (133) in all of college football.
- Oregon State's defense ranks 127th in expected points added per rush (-0.01).
- Oregon State is coming off a game in which it allowed 280 rushing yards to Oregon.
- The Beavers rank 77th in rushing yards allowed per carry (4.6). out of 136 teams, per Game on Paper.
Arizona State WR Jordan Tyson Projection: 93.5 Receiving Yards
TCU vs. Arizona State Pick – 9 p.m. ET
- Arizona State WR Jordan Tyson has recorded over 100 receiving yards in five of his last seven games dating back to last season.
- Tyson’s 17 catches of 10+ yards are the second-most in the FBS.
- TCU has allowed 27 completions of 10+ yards, tied for 53rd most.
- According to PFF, Tyson is eighth in the FBS in receiving grade (91.7).
- TCU is 55th in coverage grade, according to PFF (79.1).
Make Friday College Football Picks on PrizePicks
Friday night brings us three exciting college football games, including an ACC matchup between Florida State vs. Virginia. Another conference matchup pits Big 12 rivals TCU as they travel to Tempe, Ariz., to take on the reigning Big 12 champion, Arizona State.
The night caps off with Houston taking on Oregon State, who are trying to avoid starting 0-5 for the first time since 1996.
No matter what your Friday college football picks, there's no better way to cash in on your takes thanwith PrizePicks' real money CFB DFS game.
Just pick More or Less on player stat projections and get paid when your picks are right — all the way up to 2000x your entry fee.
Check out the Playbook for more CFB DFS picks and college football predictions throughout the season!
