The College Football Playoff rankings received a big shakeup after a weekend that featured seven ranked vs. ranked games, including losses by #1 Miami, #6 Kentucky, and #12 LSU. We have four weekends of games left to decide who will be the 12 that go to the CFP.
There are games now on almost every night of the week, including two Friday night matchups we're highlighting with intriguing potential. Today's slate includes a Big 12, Big Ten, and ACC matchup. Two of the active teams tonight are alive in the CFP race.
Below, we’ll break down our top college football predictions and picks today, including Friday analysis on spreads and more from PrizePicks for Illinois vs. #4 UCLA and Florida State vs. Pitt.
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Week 11 College Football Predictions, Picks – Friday, November 13
Two games stand out as our favorite college football picks for Friday, November 13.
Undefeated UCLA, in the driver’s seat in the Big Ten, hosts an upset-minded Illinois team that's fresh off its upset of Nebraska at 9 p.m. on FOX. Elsewhere, Florida State and Pitt meet in an ACC battle with bowl implications at 7 p.m. on ESPN.
The payouts listed below indicate real-money earnings if a prediction is correct; for example, a 2x on a $100 entry pays out $200. The lower the payout multiplier, the higher the chance of the outcome occurring, according to user picks.
Illinois vs. #4 UCLA Prediction on Spread for Friday Night
Start Time: 9 p.m. ET | TV: FOX
After last week's CFP rankings didn't seem as impressed with UCLA as its undefeated record suggested — ranking them eighth — the Bruins are up to fourth following a 14-point win at Minnesota.
However, most predictive power rankings still don’t believe in the Bruins. ESPN’s FPI has them 11th, SP+ has them 18th, while they are ranked 26th in the Elo rankings. Much of that is due to a passing offense that's 83rd in the nation, averaging only 218.7 yards per game.
The Bruins are a run-heavy offense, sitting 14th nationally at 213.2 YPG, with an elite defense that is second in defensive success rate allowed, eighth in scoring (14.1 PPG), seventh in total defense (264.7 YPG), and leads the country in both INTs (17) and takeaways (27).
UCLA is also just 49th nationally in offensive explosive play rate, leaving it more dependent on sustained drives. It ranks 86th in success rate and 133rd in explosiveness since Week 6 and lost two offensive linemen in the win at Minnesota.
The Fighting Illini have won four straight, including last Friday’s upset win over Nebraska and a 21-10 win over Oregon. Their offense is better than the traditional statistics suggest. Illinois ranks just 59th in total offense and 68th in scoring but is 21st in adjusted offensive EPA/play and 28th in success rate.
Illinois ranks 11th in fewest tackles for loss allowed (29 total, 3.22 per game) and 15th in fewest sacks given up (10 total, 1.11 per game). The Illini have also been one of the nation's most disciplined teams, slotting in at eighth in fewest penalty YPG (37.1) and tied for seventh in fewest penalties per game (4.33).
The biggest concern is an Illinois defense that's 118th in defensive success rate allowed and 125th in defensive EPA/play.
The Illinois offense welcomed back QB Katin Houser two weeks ago from a hand injury, and he’s passed for an average of 257.5 YPG with 4 TDs since his return.
UCLA has the better defense and the undefeated record, but Illinois has the offensive efficiency, recent momentum, and ability to avoid negative plays to potentially keep this game close.
Make your Illinois vs. UCLA picks on PrizePicks now.
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Florida State vs. Pittsburgh Prediction on Winner for Friday Night
Start Time: 7 p.m. ET | TV: ESPN
In its first game since firing head coach Mike Norvell, the Seminoles outlasted Boston College on the road, scoring 10 fourth-quarter points to end a three-game losing streak. Pitt also ended a three-game skid with a 23-point win over Georgia Tech two weeks ago before a bye.
Florida State leans heavily on its run game, averaging nearly 38 rushing attempts and having more than half of its offensive plays coming on the ground. Despite that approach, the Seminoles are 50th in both rushing and passing.
FSU faces a tough challenge here, as Pitt boasts one of the best rushing defenses in the country, allowing just 2.2 yards per carry (the fewest nationally) and 68.3 rushing YPG (second).
If Pitt can contain Florida State's attack on early downs, the Seminoles could find themselves in more third-and-longs, forcing them away from the identity they've relied on.
Pitt could have opportunities to move the ball against a Florida State defense that's 122nd in yardage (412.8 YPG), including 110th against the pass (239.4 YPG) and 104th against the run (173.3 YPG).
The Panthers are 24th in total offense (446.1 YPG) and 18th in passing (278.4 YPG), although they've have been without starting QB Mason Heintschel. The ground game has been led by freshman RB Damon Ferguson Jr., who went off for 185 yards and 2 TDs in the win over Georgia Tech.
Pitt is also averaging 34.7 PPG at home, while Florida State has ceded 40.3 PPG on the road.
Florida State showed some fight in its first win since the coaching change, but this is a difficult matchup for an offense that relies so heavily on the run. Pitt has the defensive front to make the Seminoles one-dimensional and a passing attack capable of exploiting a defense that's struggled.
Now rested up and playing at home on Senior Night, the Panthers have several advantages against the visiting Seminoles.
Make your Florida State vs. Pittsburgh picks on PrizePicks now.
Make College Football Predictions Today on PrizePicks
Can Illinois end UCLA’s perfect season? Will Florida State win its second straight since making a coaching change? Friday night's college football slate contains plenty of exciting possibilities.
You can make your college football predictions every week of the 2026 season on PrizePicks — including teams to pull off upsets in Week 11.
With PrizePicks, just pick players, predict More or Less on their stats, and cash in if you're right. In eligible states, you can also make predictions on game winners, spreads, over/unders, and more.
Stay locked in on Playbook for college football picks, predictions, and news all season long.
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