Wyoming vs. UNLV Prediction, Spread, NCAAF Picks for Saturday, November 7

The Wyoming Cowboys head south to face the UNLV Rebels in a key Mountain West matchup. Kickoff is set for Saturday, November 7 at 10:30 p.m. ET from Allegiant Stadium in Las Vegas on CBS Sports Network.  According to PrizePicks, UNLV is a 3.5-point favorite for the spread.

Wyoming (5-3) sits one game behind MWC leader New Mexico heading into Saturday’s action. The Cowboys seek their fourth consecutive victory after a 28-14 home victory over Air Force.

The Rebels (5-3) held off Northern Illinois as 21.5-point home favorites in a 31-24 triumph to improve to 3-1 in conference action. 

Below, we'll break down our Wyoming vs. UNLV prediction and picks for Saturday's college football game, including the winner, over/under, and key player picks for PrizePicks.

Make your Wyoming vs. UNLV picks on PrizePicks now.

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Wyoming vs. UNLV Prediction, Spread, Over/Under – Saturday, November 7

The Rebels enter Saturday’s game as 3.5-point favorites against the Cowboys. Wyoming returns a 2.5x payout if they win outright, via PrizePicks.

Here are the full payouts for the Wyoming vs. UNLV game. PrizePicks data is live at the time of writing and is subject to change.

Make your Wyoming vs. UNLV prediction on winner, over/under, and more on PrizePicks!

Somehow, Wyoming is 4-1 in conference play despite owning the nation’s 123rd-ranked net adjusted EPA/play, according to Game on Paper. The Cowboys also sit 126th in the country in defensive success rate, but that side of the ball has improved recently.

Since getting shut out 28-0 at North Dakota State, the Cowboys have allowed an average of 16.6 points per game (PPG) during their three-game winning streak. 

Air Force produced 10 more first downs than Wyoming (23-13) on October 23, while the Cowboys were outgained by 93 yards. However, Wyoming QB Tyler Hughes scampered for a 68-yard TD run on the second play from scrimmage, and the Cowboys never trailed as 6.5-point home underdogs.

The Rebels failed to score more than 21 points in each of their first three games but have topped the 31-point mark in four of the past five outings. 

UNLV’s two highest-scoring games came in non-conference wins over Akron (38-10) and California (39-31), two teams that are each in the bottom 20 of points allowed per game in the nation.

Head coach Dan Mullen’s squad allowed three consecutive fourth quarter TDs in a 41-31 defeat to Air Force in mid-October before rebounding for last week’s 31-24 triumph over Northern Illinois. UNLV scored 2 TDs of 60 yards or more, including a 75-yard TD pass from QB Jackson Arnold on the first play from scrimmage.

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Wyoming vs. UNLV Prediction on Spread – 11/7/26

Here are the key game stats and trends behind our Wyoming vs. UNLV prediction on the spread for Saturday, November 7.

• The Cowboys are 4-1 against the spread (ATS) since beginning the season with three ATS losses.
• UNLV won at Wyoming last season 31-17 as 4.5-point road favorites. The Rebels were outgained by 100 yards but scored 2 TDs on blocked punt returns.
• The Rebels are 3-4 ATS in the favorite role and 6-8 ATS when laying points since last season’s victory at Wyoming.
• UNLV ranks 21st in defensive EPA/pass but drops to 123rd in defensive EPA/rush.
• The Cowboys have leaned on their ground game, ranking eighth in EPA/rush.
• Wyoming owns the second-highest yards per rush (5.2) among MWC teams, as the Cowboys have averaged over 7.0 yards per rush in the last two wins.

Lock in your Wyoming vs. UNLV prediction on PrizePicks.

Wyoming vs. UNLV Picks, Player Stats for PrizePicks – 11/7/26

Here are top Wyoming vs. UNLV picks to target on PrizePicks for Saturday, November 7. Today’s college football picks for PrizePicks include QB Tyler Hughes and QB Jackson Arnold.

Wyoming QB Tyler Hughes vs. UNLV: 152.5 Pass Yards

• Hughes actually produced more rushing yards (146) than passing yards (113) in the victory over Air Force.
• In five of eight games, Hughes has been held to fewer than 150 passing yards. His highest road output was 173 yards in a 24-10 defeat at Central Michigan. 
• Wyoming is 124th in EPA/pass, while Hughes hasn’t completed more than 17 passes against an FBS opponent.
• The Rebels allowed a season-high 253 yards to Northern Illinois QB Taron Dickens last week, marking the seventh opposing QB to compile at least 170 passing yards.

Add Tyler Hughes to your PrizePicks lineup now.

UNLV QB Jackson Arnold vs. Wyoming: 199.5 Pass Yards

• Arnold is fresh off a 269-yard passing performance against Northern Illinois, his fourth 200+ yard passing game of 2026.
• Five QBs have thrown for at least 200 yards against Wyoming with only two of those coming on the road.
• Arnold has produced an EPA of 6.3 or higher in three games, averaging 268.3 passing yards.
• In the last three games that Wyoming has allowed at least 200 passing yards, those QBs averaged 42.0 passing attempts. Arnold put up 33 and 30 pass attempts in the past two games.   

Add Jackson Arnold to your PrizePicks lineup now.

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Make Wyoming vs. UNLV Picks on PrizePicks

New Mexico is the team to beat in the Mountain West, but Wyoming and UNLV are chasing down the Lobos. Can the Cowboys stay hot, or will the Rebels beat Wyoming for a third straight time?

Don’t wait until lock — make your Wyoming vs. UNLV picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 36 states.

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