Tigers vs. Twins Prediction, MLB Picks for Wednesday, September 2

The Detroit Tigers and the Minnesota Twins will put a bow on a three-game series on Wednesday, September 2, at 7:40 p.m. ET. Ahead of the first pitch, the Twins are a slight home favorite with a 1.81x payout to secure a victory on PrizePicks Team Picks.

Minnesota has won the first two games of the series by a combined score of 26-3, so Detroit is looking to keep it more competitive and avoid a sweep on Wednesday.

Below, we'll break down our Tigers vs. Twins prediction and picks for Wednesday’s MLB contest, including the run line, over/under, and key player picks for PrizePicks.

Make your Tigers vs. Twins prediction and picks on PrizePicks now!

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Tigers vs. Twins Prediction, Winner Payout, Over/Under – Wednesday, September 2

To wrap up the series, Tigers SP Drew Anderson (3.69 xFIP across 86.0 IP) and Twins SP Dean Kremer (4.00 xFIP across 62.2 IP) will face off on the mound.

Ahead of his eighth start of the season, Anderson ranks in the 62nd percentile in xERA (3.81) and 71st percentile in xBA (.224), per Baseball Savant. Anderson has made 38 relief appearances for the Tigers, and his biggest concerns are a 33rd-percentile walk rate (9.7%) and 36th-percentile barrel rate (8.2%).

While Kremer has a 5.60 ERA, he carries a 4.48 xERA (30th percentile) and a 45th-percentile xBA (.244). Kremer is set to make his sixth start for the Twins on Wednesday.

Over the last two weeks, Detroit’s bats have gone ice-cold, tallying the worst wRC+ (48), worst wOBA (.239), and second-worst ISO (.093), per FanGraphs. Meanwhile, Minnesota has registered the fifth-best wRC+ (115), fifth-best wOBA (.336), and second-best ISO (.190) during that same two-week sample.

Both of these teams are considered long shots to advance to the postseason, as 'Yes' for the Twins to make the playoffs has a 5.88x payout, compared to 'No' at a 1.09x payout. On the other hand, the Tigers have just a 22.22x payout to reach the playoffs.

Tigers vs. Twins Winner Payout, Over/Under – Wednesday, September 2

The Twins enter Wednesday’s game as a home favorite against the Tigers, returning a 1.81x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Tigers vs. Twins game on PrizePicks.

Make your Tigers vs. Twins prediction on the spread or over/under on PrizePicks Team Picks to earn real money—available in 36 states!

Team Picks data is live at the time of writing and is subject to change.

Tigers vs. Twins Prediction on Over/Under – 9/2/26

Here are the key game stats and trends behind our Tigers vs. Twins prediction on the total runs scored for Wednesday, September 2.

• There have been at least 9 total runs scored in seven of the nine head-to-head meetings between the Tigers and Twins this season.
• Even with Detroit struggling at the plate recently, Kremer has given up at least 4 ERs in two of his last three starts.
• Minnesota’s relievers have also posted the ninth-worst xFIP (4.31) and third-worst BABIP (.339) in the last 14 days.
• Anderson coughed up at least 3 ERs in two of his last three starts.
• Detroit’s bullpen has also sputtered, logging the second-worst xFIP (5.42) and second-worst HR/9 (1.94) over the last two weeks.
• On the season, the Twins have the fifth-best wRC+ (109), seventh-best wOBA (.326), and third-best ISO (.176) against right-handed pitching.

Lock in your Tigers vs. Twins prediction on PrizePicks before the line moves.

Tigers vs. Twins Picks, Player Stats for PrizePicks: 9/2/26

Here are the top Tigers vs. Twins picks to target on Wednesday, September 2. Today’s MLB picks for PrizePicks include Kevin McGonigle and Luke Keaschall.

Tigers SS Kevin McGonigle vs. Twins: 1.5 Hits + Runs + RBIs

• Kremer is logging a 4.49 xFIP, 1.42 WHIP, and 2.21 HR/9 against left-handed hitters this season.
• When facing right-handed pitching this year, McGonigle touts a 142 wRC+, .376 wOBA, and .159 ISO.
• On the road, McGonigle carries a 141 wRC+, .373 wOBA, and .179 ISO.
• McGonigle has achieved at least 2 hits + runs + RBIs in three of his last four games.

Add Kevin McGonigle to your PrizePicks lineup now.

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Twins 2B Luke Keaschall vs. Tigers: 5.5 Hitter Fantasy Score

• Anderson is tallying a 1.46 WHIP and 1.64 HR/9 against righties, compared to a 1.22 WHIP and 1.13 HR/9 against lefties.
• Keaschall is notching a 124 wRC+, .349 wOBA, and .135 ISO when facing a right-handed pitcher in 2026.
• During August, Keaschall owned a 178 wRC+, .426 wOBA, and .235 ISO.
• Across his last 10 games, Keaschall has 6 multi-hit performances, 2 HRs, 7 RBIs, 5 doubles, 2 SBs, and 8 runs scored.

Add Luke Keaschall to your PrizePicks lineup now.

Make Tigers vs. Twins Picks on PrizePicks

The Twins have lit up the scoreboard against the Tigers recently, including a 15-2 victory on Tuesday. With Anderson and Kremer on the bump in Wednesday’s series finale, another high run total could be ahead.

Don’t wait until the first pitch happens—make your Tigers vs. Twins picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 36 states.

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