Thunder vs. Trail Blazers Prediction, Spread, NBA Picks – Wednesday, November 11

Following their clash on the hardwood on Tuesday night, the Oklahoma City Thunder and Portland Trail Blazers are right back under the bright lights on Wednesday, November 11 in the same situation. The two teams meet at 10 p.m. ET, with OKC favored by 1.5 points on PrizePicks.

When two of the Western Conference’s best teams go head-to-head, there could be plenty of points put up on the scoreboard. As Oklahoma City attempts to keep withstanding injuries and Portland aims to maintain its surprise start, which side comes out on top in this second leg of a back-to-back?

Below, we’ll break down our Thunder vs. Trail Blazers prediction and picks for Wednesday’s NBA game, including the winner, spread, over/under, and key player picks for PrizePicks.

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Thunder vs. Trail Blazers Prediction, Spread, Over/Under – Wednesday, November 11

The Thunder enter Wednesday’s game as 1.5-point road favorites against the Trail Blazers, returning a 1.78x payout on PrizePicks with a victory.

Here are the full payouts for Thunder vs. Trail Blazers on PrizePicks.

Make your Thunder vs. Trail Blazers pick against the spread or on the over/under on PrizePicks.

Payouts show potential returns on correct Team Picks predictions. A 2x payout returns $200 on a $100 entry. Lower multipliers reflect outcomes users are picking as more likely. Payouts are live as of writing and subject to change.

Fresh off a 64-win campaign and a trip to the Western Conference Finals, the Thunder seemed primed to pick up where they left off in 2026-27. They technically have managed to do so, boasting the sport’s fifth-best defensive rating (107.5) and 11th overall net rating (+5.5), albeit under much different circumstances.

SF Jalen Williams and G Cason Wallace are out for most or all of the season with respective ankle and shoulder injuries, and PF-C Chet Holmgren is also on the shelf with a knee issue that crept up early in the campaign. No high-profile team has been bitten by the injury bug worse than Oklahoma City, yet Mark Daigneault’s crew remains 8-3 entering Wednesday’s play.

The Thunder have ripped off four wins in their last five games, and all-world PG Shai Gilgeous-Alexander continues to lead the way. Elsewhere, G Ajay Mitchell’s 18.5 PPG on 52.3% shooting has helped keep the offense afloat. 

Nearly matching OKC’s record is Portland at 7-3, as Micah Nori’s first year at the helm is off to a roaring start. Following a promising 42-40 season and a trip to the NBA Playoffs for the first time since the 2020 campaign, the Blazers are back with a new head coach but a familiar roster.

The prime difference is the return of PG Damian Lillard from an Achilles injury after sitting out 2025-26. Lillard is second to only SF Deni Avdija in per-game scoring average at 20.0, also canning 34.9% of his 8.3 nightly 3-point attempts. Despite losing PG Ja Morant to a hamstring injury a couple of weeks ago, this group is still potent and has the #4 offensive rating (120.3) in the NBA. 

Oklahoma City took three of four matchups between the sides last season, but it was Portland that got the most recent laugh in Tuesday’s throttling. The Blazers’ home cooking contributed to a 20-point advantage in the end, covering the 1.5-point spread with ease.

Thunder vs. Trail Blazers Prediction on Spread – 11/11/26

Here are the key game stats and trends behind our Thunder vs. Trail Blazers pick against the spread for Wednesday, November 11’s NBA game.

• Oklahoma City is an even 2-2 against the spread as a road favorite this year. Portland, as a home underdog, is also .500 ATS at 1-1.
• The Thunder have been considerably more careful with the ball thus far, posting an 11.5% turnover-per-play clip to the Blazers’ mark of 13.9%. 
• OKC’s defense is a decent chunk more disruptive than Portland’s in the early going, owning respective edges of 0.9% in block rate and 0.6% in steals per play.
• The Trail Blazers allow opponents to shoot 47.2% from midrange, the fifth-highest threshold in the NBA. 
• There’s a significant gap in how disciplined these defenses are. Oklahoma City’s foes average a 24.0% free throw rate, fifth-lowest leaguewide. Portland is dragging far behind with a 31.9% mark, good for only 23rd.

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Thunder vs. Trail Blazers Picks, Player Stats for PrizePicks: 11/11/26

Here are the top Thunder vs. Trail Blazers picks to target on Wednesday, November 11. Today’s top NBA picks for PrizePicks include PG Shai Gilgeous-Alexander and SF Deni Avdija.

Thunder PG Shai Gilgeous-Alexander vs. Trail Blazers: 33.5 Points

• The back-to-back MVP is pouring in 29.5 PPG, also taking a career-high 6.6 3-pointers per night and making them at a 37.0% rate.
• Dating back to the 2024-25 season, Gilgeous-Alexander produces 16.1 more points per 100 possessions with a 13.9% higher usage rate without the trio of Williams, Holmgren, and Wallace.
• SGA’s 40.4% on-ball rate ranks in the 84th percentile, via databallr, and his 39.1 true shot attempts per 100 are in the 100th percentile.
• According to FantasyPros, the Trail Blazers surrender the third-most PPG to the PG position (31.48) this season.

Add Shai Gilgeous-Alexander + Thunder to win to your PrizePicks lineup now.

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Trail Blazers SF Deni Avdija vs. Thunder: 37.5 Pts + Rebs + Asts

• After making his first career All-Star team, Avdija is managing a nightly average of 35.4 combined points, rebounds, and assists. That number is holding steady at 35.2 in his last five games.
• Deni is finding his touch from midrange, making 60.0% of his tries from 10-16 feet. That’s a personal best for him, with those shots making up 6.5% of his overall diet.
• The veteran forward’s 7.8% self-rebounding clip is an 89th-percentile benchmark 15.3% defensive rebounding rate isn’t far behind (81st percentile).
• Per NBA RAPM, Avdija is logging a career-high 24.4 assist points per 100.

Add Deni Avdija + Trail Blazers to cover the spread to your PrizePicks lineup now.

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The Western Conference standings are jam-packed at the top to begin the new season, as a whopping eight teams are within just a couple games of each other. Following Tuesday’s statement win from Portland, is a repeat in store, or can Oklahoma City respond?

Don’t wait until tip-off today — make your Thunder vs. Trail Blazers picks on PrizePicks now.

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