Celtics vs. 76ers Prediction, Spread, NBA Picks – Tuesday November 10

The top two teams in the Eastern Conference meet tonight as the Philadelphia 76ers host the Boston Celtics. Tipoff is set for 8:00 p.m. ET on Tuesday, November 10, at Xfinity Mobile Arena in Philadelphia on NBC. According to PrizePIcks, the Celtics are 1.5-point favorites on the spread tonight.

The 76ers (9-2) bounced back from their second loss with Sunday’s 127-121 victory at the Bulls but failed to cover as 9.5-point favorites. Boston (8-2) makes the third stop of a four-game road trip, coming off consecutive 20+ point blowout wins over the Hornets and Bucks.

Below, we'll break down our Celtics vs. 76ers prediction and picks for Tuesday's NBA game, including the spread, over/under, and key player picks for PrizePicks.

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Celtics vs. 76ers Prediction, Spread, Over/Under – Tuesday, November 10

The Celtics enter Tuesday’s game as 1.5-point road favorites against the 76ers. If Philadelphia wins outright, it returns a 1.92x payout via PrizePicks.

Here are the full payouts for the Celtics vs. 76ers game. PrizePicks data is live at the time of writing and is subject to change.

Make your Celtics vs. 76ers prediction on the winner on PrizePicks!

The storylines are not lacking heading into this playoff rematch. Philadelphia erased a 3-1 deficit to shock Boston in the first round last season. It marked the end of G/F Jaylen Brown’s 10-year tenure with the Celtics, as he was dealt to the 76ers in July.

Brown’s scoring average dropped from 28.7 points per game (PPG) to 22.3 PPG this season. However, the 76ers are +49 with Brown on the court, according to Hoops Junkie, and their defensive rating is -11.4 worse when he’s on the bench.

Another key offseason acquisition for the 76ers was signing F LeBron James, who is posting his lowest effective field goal percentage (eFG%) since his rookie season, per NBA.com. 

Philadelphia owns a 4-1 home mark, including victories over Cleveland and New York. The lone blemish came to the Pistons on October 25, but the 76ers picked up revenge with a 112-106 victory last Wednesday at Detroit.

The key piece returning to Boston in the Brown trade was F Paul George, who has eclipsed his scoring average from his two-year stay in Philadelphia. After not averaging more than 17.3 PPG with the 76ers, George is posting 20.4 PPG in Boston, to go along with 42.5% shooting from downtown.

And then there’s F Jayson Tatum, who sat out the Game 7 loss to Philadelphia last season with left knee stiffness. Tatum ranks 11th in the NBA in net rating, while posting the second-highest scoring average of his career at 27.1 PPG.

Since blowing a 22-point lead at Detroit in the opener, the Celtics have won three of their past four road games. Boston captured three of five matchups at Philadelphia last season, including a pair of victories in its first round playoff series. 

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Celtics vs. 76ers Prediction on Winner – 11/10/26

Here are the key game stats and trends behind our Celtics vs. 76ers prediction on the winner for Tuesday, November 10, in the NBA game.

• The Celtics rank fifth in the NBA in offensive rating of 117.9, a slight drop from their rating of 120.0 last season.
• The 76ers are tied with the Knicks for the fourth-lowest eFG% at 51.1%, while shooting 49.1% in the last three games.
• Philadelphia leads the league with the lowest turnover rate per game (12.8%). Boston sits fifth in defensive turnover rate (17.4%).
• The Sixers compiled a 6-3-1 against the spread record vs. the Celtics last season. Four of the covers came as an underdog of 5.5 points or more.
• The Celtics are listed as a favorite of less than 3 points for the third time. Boston split against Detroit and New York in the first two tries.
• Boston is averaging 15.6 made 3-pointers per game, while Philadelphia is allowing 31.6% shooting from downtown (third lowest).

Lock in your Celtics vs. 76ers prediction on PrizePicks before tonight’s NBA game.

Celtics vs. 76ers Picks, Player Stats for PrizePicks – 11/10/26

Here are the top Celtics vs. 76ers picks to target on PrizePicks for Tuesday, November 10. Today’s NBA picks for PrizePicks include Jayson Tatum and Joel Embiid.

Celtics F Jayson Tatum vs. 76ers: 26.5 Points

• Tatum has been held below this projection in nine of the last 10 games against teams ranked in the top 10 of defensive rating, according to Props Madness.
• Last season, Tatum averaged 23.3 PPG in six games against Philadelphia. His highest output was 30 points in the Game 4 playoff victory.
• The 76ers haven’t allowed more than 21 points to an opposing small forward this season.
• Tatum’s eFG% drops from 53.6% at home down to 43.0% on the road. Last season, Tatum had a 48.5% eFG% away from TD Garden.

Add Jayson Tatum to your PrizePicks lineup now!

76ers C Joel Embiid vs. Celtics: 28.5 Pts + Rebs

• Embiid is averaging 24.4 P+R in the last five games. He began the season posting a P+R average of 31.5 over the first four contests.
• In the final four games against Boston last season, Embiid compiled at least 36 P+R three times. 
• Embiid’s usage has eclipsed 30% in each of his first 10 seasons but is a career-low 28.1% this season. 
• In seven of nine games, Embiid has missed at least 9 field goal attempts. The Celtics are second across the NBA in defensive field goal percentage (42.3%).

Add Joel Embiid to your PrizePicks lineup now!

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Boston looks for revenge after last season’s first-round meltdown against Philadelphia. Will Brown light up his former team, or can the Celtics jump the 76ers for first place in the Atlantic Division?

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