An intriguing Western Conference battle will take center stage on Tuesday, November 10, as part of the NBA’s six-game slate. The Portland Trail Blazers will host the Oklahoma City Thunder at 11:00 p.m. ET on NBC. According to PrizePicks, the Thunder are 1.5-point favorites on the spread.
The Thunder have been one of the league’s hottest teams lately, winning four straight games, including a 114-75 win over the Washington Wizards on Saturday. Meanwhile, the Trail Blazers have dropped back-to-back games against the Los Angeles Lakers and San Antonio Spurs.
Below, we'll break down the matchup for our Thunder vs. Trail Blazers prediction and NBA picks, including on the winner, spread, over/under, and key player projections on PrizePicks.
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Thunder vs. Trail Blazers Prediction, Spread, Over/Under – Tuesday, November 10
The Thunder enter Tuesday’s matchup as 1.5-point road favorites, returning a 1.75x payout if they win outright.
Here are the full payouts for the Thunder vs. Trail Blazers matchup. PrizePicks data is live at the time of writing and is subject to change.
Make your Thunder vs. Trail Blazers prediction on the spread on PrizePicks.
Stats used in this article are from Basketball Reference, NBA.com, or databallr unless stated otherwise.
The Thunder have dealt with a ton of adversity early in the 2026-27 season. Oklahoma City is currently without C Chet Holmgren (knee), G Jalen Williams (ankle), and G Cason Wallace (shoulder) for the foreseeable future.
Williams suffered a dislocated ankle and a fractured fibula in a game against the Los Angeles Clippers in late October and will miss several months before being reevaluated.
Meanwhile, Holmgren suffered a small tear in the patellar tendon of his right knee and will miss 8 to 10 weeks. Holmgren is expected to return in late December or early January.
Despite the abundance of injuries to its key players, the Thunder have still managed to begin the season 8-2. Oklahoma City has defeated the Cleveland Cavaliers twice and topped a hot Memphis Grizzlies team during its current four-game win streak.
As should come as no surprise, the Thunder have leaned on two-time NBA MVP Shai Gilgeous-Alexander to shoulder the offensive load. Gilgeous-Alexander has racked up 35.8 PPG while shooting 51.7% on 3-pointers during the team’s current four-game winning streak.
The Thunder have also seen increased productivity from G Jared McCain, who was acquired at the trade deadline last season. McCain has averaged 20.0 PPG and is shooting 41.7% (5 of 12) on triples across his last two contests.
The Trail Blazers returned to the NBA playoffs for the first time in five seasons in 2025-26. Portland earned the No. 7 seed in the Play-In Tournament but was ultimately defeated by the San Antonio Spurs in five games in the first round.
Portland is looking to carry that momentum into the 2026-27 campaign and has gotten off to a 6-3 start.
The Blazers were on track to take down the Lakers in Friday’s contest before the Los Angeles outscored Portland 71-58 in the second half to come away with a 124-118 win. The Trail Balzers followed that up by getting dominated by the Spurs in a 125-103 defeat on Saturday.
Some of the wind for Portland's sails has been taken away, with G Ja Morant out of the lineup. Morant is currently sidelined with a Grade 2 hamstring strain and will miss at least four weeks.
Morant was acquired in a trade with the Memphis Grizzlies in the offseason. The veteran guard recorded 15.8 PPG and 5.5 APG while sharing the backcourt with G Damian Lillard early in the season. The Trail Blazers will continue to lean on F Deni Avdija, who is averaging a team-high 22.3 PPG this season.
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Thunder vs. Trail Blazers Prediction on Spread – 11/10/26
Here are the key stats behind our Thunder vs. Trail Blazers prediction on Tuesday, November 10, including a pick for the spread on PrizePicks.
- The Thunder are 7-3 against the spread this season, while the Trail Blazers are just 5-5 against the spread.
- Oklahoma City has allowed the fewest PPG in the NBA this season (104.2).
- The Thunder have also defended the perimeter extremely well, holding their opponents to 32.6% shooting from 3-point land (sixth lowest).
- Oklahoma City has really thrived on the glass, pulling down the fifth-most RPG in the league (47.3), including a league-best 35.9 defensive rebounds.
- The Trail Blazers struggle to take care of the basketball, committing the sixth-most turnovers per contest (16.3).
- Oklahoma City has won nine of the last 10 meetings against Portland by an average margin of +15.0 PPG dating back to the 2023-24 season.
Lock in your Thunder vs. Trail Blazers prediction on PrizePicks before tipoff.
Thunder vs. Trail Blazers Picks, Player Stats on PrizePicks: 11/10/26
For NBC's nightcap for its doubleheader, our top Thunder vs. Trail Blazers player picks for Tuesday, November 10, on PrizePicks include G Shai Gilgeous-Alexander and G Damian Lillard.
Thunder G Shai Gilgeous-Alexander vs. Trail Blazers: 32.5 Points
- Gilgeous-Alexander is averaging 29.9 PPG (fourth in the NBA) but has increased that to 35.8 PPG over his last four contests.
- The Thunder star topped 40 points twice in his last four games and logged 35+ minutes in each.
- As the top total in the Association, SGA has registered 38.4 true shot attempts per 100 possessions.
- Gilgeous-Alexander has really been lighting it up from beyond the arc, connecting on 39.1% of his 3-point shots.
Pick Shai Gilgeous-Alexander + Thunder to win for biggest payouts on PrizePicks.
Trail Blazers G Damian Lillard vs. Thunder: 23.5 Pts + Asts
- Lillard has averaged 19.4 PPG and 4.4 APG in nine games this season.
- The Trail Blazers’ guard spends 41.0% of his time on the court on-ball, ranking in the 83rd percentile.
- Lillard’s teammates own a 76.0% effective field goal percentage on assists from the nine-time All-Star.
- The former lottery pick has recorded at least 24 points and assists in six of his nine games in 2026-27.
Add Damian Lillard + Trail Blazers spread for bigger payouts on PrizePicks.
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Make Thunder vs. Trail Blazers Picks on PrizePicks
Despite being shorthanded, the Thunder have been playing inspired basketball recently. Will Oklahoma City keep its stellar play going against Portland in Tuesday’s road contest?
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