Cavaliers vs. Knicks Prediction, Spread, NBA Picks – Wednesday, November 11

Two Eastern Conference teams that have gotten off to interesting starts will face off on Wednesday evening. The New York Knicks will host the Cleveland Cavaliers at 7 p.m. ET on ESPN. According to PrizePicks, the Knicks are 4.5-point favorites on the spread.

After starting the season on a three-game losing streak, the Knicks have found their stride and are currently riding a four-game winning streak, including a 117-85 win against the Milwaukee Bucks on Tuesday. 

Meanwhile, the Cavaliers have lost four of their last five, including a 124-112 loss to the Charlotte Hornets on Monday. 

Below, we'll break down the matchup with our Cavaliers vs. Knicks prediction and NBA picks, including on the winner, spread, over/under, and key player projections on PrizePicks.

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Cavaliers vs. Knicks Prediction, Spread, Over/Under – Wednesday, November 11

The Knicks enter Wednesday’s matchup as 4.5-point home favorites, returning a 1.49x payout if they win outright.

Here are the full payouts for the Cavaliers vs. Knicks matchup. PrizePicks data is live at the time of writing and is subject to change.

Make your Cavaliers vs. Knicks prediction on the spread on PrizePicks.

Stats used in this article are from Basketball Reference, NBA.com, or databallr unless stated otherwise.

The Knicks ended a 53-year championship drought when the franchise won an NBA title last season. New York was able to defeat the San Antonio Spurs to bring the Larry O’Brien Trophy back to the Big Apple.

With a similar team in tow, New York had gotten off to a less-than-stellar start this campaign, winning just two of its initial six games. However, the Knicks have since played some very inspired basketball.

NBA Finals MVP Jalen Brunson continues to be the driving force. After all, the star PG serves as the team’s primary ball-handler, spending an NBA-leading 59.5% of the time on-ball. Brunson has averaged 26.2 PPG and is shooting 36.8% from beyond the arc. 

The Knicks also hang their hats on defense and crash the glass aggressively. That’s among the reasons that New York was so successful throughout its championship run. 

Meanwhile, the Cavaliers reached the Eastern Conference Finals before being swept by the Knicks. It marked the first time the Cavs made the ECF since 2018, when LeBron James was on the team.

Despite coming off an impressive campaign, that same success hasn’t carried over. The Cavaliers currently have a 5-6 record and have dropped five of their last seven contests.

Efficiency has been an issue in the early going. PG James Harden is averaging just 15.3 PPG while shooting 36.4% from the field. Meanwhile, SG Donovan Mitchell is averaging 22.8 PPG, down from 27.9 PPG last season. 

The Cavaliers have also struggled on the defensive end, allowing 115.0 PPG (18th) and letting opponents shoot 35.5% from beyond the arc (19th). 

Cavaliers vs. Knicks Prediction on Spread – 11/11/26

Here are the key stats behind our Cavaliers vs. Knicks prediction on Wednesday, November 11, including a pick against the spread on PrizePicks.

• The Knicks are 5-0 against the spread in their last five meetings against the Cavaliers.
• New York has played lockdown defense, allowing a league-low 102.2 PPG. The Knicks have also defended the perimeter well, holding their opponents to 33.3% shooting from 3-point land (eighth).
• The Knicks limit the opposition’s transition opportunities, holding them to the third-fewest fast-break PPG (11.7).
• Offensively, the Knicks assist on 71.7% of their made shots, ranking seventh in the NBA.
• New York dominates the boards, sitting third in the league in RPG (48.3) behind only the San Antonio Spurs (49.1) and Minnesota Timberwolves (48.8).
• The Knicks won seven of the eight meetings outright last season and covered in six of those matchups. 

Lock in your Cavaliers vs. Knicks prediction on PrizePicks before tip-off.

Cavaliers vs. Knicks Picks, Player Stats on PrizePicks: 11/11/26

Our top Cavaliers vs. Knicks player picks for Wednesday, November 11 on PrizePicks include PF-C Evan Mobley and C Karl-Anthony Towns.

Cavaliers PF-C Evan Mobley vs. Knicks: 27.5 Pts + Rebs + Asts

• Mobley has registered at least 28 points, rebounds, and assists in seven of his 11 games this season.
• The Cavaliers big man is shooting 50.0% from beyond the arc, ranking in the 93rd percentile. 
• Mobley has pulled down 50.6% of his contested rebounds.
• The former lottery pick notches 9.8 potential assists per 100 possessions (95th percentile).

Pick Evan Mobley + Cavaliers to win for biggest payouts on PrizePicks.

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Knicks C Karl-Anthony Towns vs. Cavaliers: 33.5 Pts + Rebs

• Towns has averaged 20.9 points and a league-high 13.8 rebounds this season.
• Leading all NBA players, the Knicks’ star big is securing 33.3% of his available defensive rebounds.
• Towns has tallied 25.5 true shot attempts per 100 possessions, ranking in the 94th percentile.
• The six-time All-Star has averaged 14.3 boards across his last four contests, including grabbing 13 against the Cavaliers on Saturday. 

Add Karl-Anthony Towns + Knicks spread to your lineup for bigger payouts on PrizePicks.

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The Knicks have hit their stride recently and have had the Cavaliers’ number in their recent meetings. Can New York continue to hold the upper hand?

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