Red Sox vs. Yankees Prediction, MLB Picks for Saturday, June 6

The first pitch of the Boston Red Sox (27-35) vs. the New York Yankees (37-26) is set for 7:35 p.m. ET on Saturday, June 6, with the Yankees returning a 1.81x payout to win, via PrizePicks.

Friday's series opener had all the excitement you want from a Red Sox vs. Yankees matchup. Yankees 1B Ben Rice got it going with a solo home run in the first inning, but the Red Sox responded with 2 runs in the second inning and 1 more in the third. Boston extended its lead to 5-2 with a 2-run home run from 1B Willson Contreras in the fifth inning to eventually win 5-3.

Below, we'll break down our Red Sox vs. Yankees prediction and picks for Saturday’s MLB matchup, including the run line, over/under, and key player picks for PrizePicks.

Make your Red Sox vs. Yankees picks on PrizePicks for tonight's game.

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Red Sox vs. Yankees Prediction, Winner Payout, Over/Under – Saturday, June 6

The Red Sox will start SP Ranger Suarez (3.50 xFIP across 11 starts and 58.2 IP in 2026). Suarez was one of the Red Sox's big signings in the offseason, and he’s unfortunately been inconsistent throughout the season.

He’s looked fantastic at times, with 5 starts without allowing an earned run, but he has 5 starts in which he allowed 4 or more earned runs. Suarez is just one part of a disastrous season in Boston.

The Red Sox moved on from their World Series-winning manager Alex Cora after the team started 10-17 and brought in their Triple-A affiliate manager Chad Tracy. But that hasn't yielded much results with a 17-18 record under Tracy.

The Yankees will counter with SP Will Warren (3.53 xFIP across 12 starts and 64.1 IP in 2026). Warren is having his breakout season in one of the top rotations in baseball. The Yankees’ starters rank second in the league with a 3.07 ERA and fifth with a 3.47 xFIP, and Warren has played an integral part by allowing 2 or fewer earned runs in 9 of 11 starts this season.

Following the injury of three-time MVP Aaron Judge, New York's batting order has taken a massive hit. Will it survive without its captain, who ranks 16th with a .389 wOBA and 30th with a 2.2 WAR?

The Yankees have players who can anchor this lineup, including 1B Ben Rice, who ranks second in MLB for wOBA (.435). Now we’re seeing players who struggled early in the year turn it around, including 2B Jazz Chisholm Jr., who has a .949 OPS over his last six games, and OF Trent Grisham, who boasts a .349 BA over his last 11 games.

Red Sox vs. Yankees Winner Payout, Over/Under – Saturday, June 6

The Yankees enter Saturday’s game as home favorites, returning a 1.81x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Red Sox vs. Yankees game on PrizePicks.

• Spread: Yankees -1.5 (2.56x payout)
• Over/Under: 8.5 (1.85x payout on Over)
• Game Winner Payout: Red Sox 1.92x | Yankees 1.81x

Make your Red Sox vs. Yankees prediction on the spread or over/under on PrizePicks Team Picks to earn real money — avaialble in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Red Sox vs. Yankees Prediction on Spread – 6/6/26

Here are the key game stats and trends behind our Red Sox vs. Yankees prediction on the run line for Saturday, June 6.

Lock in your Red Sox vs. Yankees prediction on PrizePicks before the first pitch.

Data used in this article is from Baseball Savant or FanGraphs.

• The Yankees swept the Red Sox in Boston by a combined score of 12-3 this season.
• New York excels against below-average teams, with a league-best 33-16 record against teams under .500.
• Suarez struggled in his last start against the Yankees, allowing 4 earned runs over 4.2 innings in the loss.
• The left-handed Suarez could struggle again, as the Yankees crush southpaws. New York leads the league with a .806 OPS and .351 wOBA against lefties.
• The Yankees also have a 14-6 record when facing a left-handed starter.
• Warren has been stellar over his last four starts, posting a 2.78 ERA while the Yanks won each game.
• The right-handed Warren has a solid 25.8% strikeout rate that ranks in the 73rd percentile. The Red Sox are below average with a 22.2% strikeout rate against righties.

Red Sox vs. Yankees Picks, Player Stats for PrizePicks – 6/6/26

Here are the top Red Sox vs. Yankees picks to target on PrizePicks for Saturday, June 6. Today’s MLB picks for PrizePicks include Cody Bellinger and Willson Contreras.

Red Sox 1B Willson Contreras vs. Yankees: 5 Hitter Fantasy Score

• Contreras is arguably having his best season, as his .270 xBA, .520 xSLG, and .400 wOBA are all career highs.
• He’s been one of the hottest hitters in baseball recently; his .515 wOBA and .417 BA since May 16 rank second in the league.
• The Red Sox first baseman’s 14.3% barrel rate is one of the best in the league, sitting in the 87th percentile. That could be an advantage over Warren, whose 6.6% barrel rate allowed ranks only in the 63rd percentile.
• Contreras mostly bats fourth in the lineup and has a .297 BA and a .887 OPS in that spot. Warren has struggled against cleanup hitters, allowing a .286 BA and .965 OPS.

Add Willson Contreras to your PrizePicks Lineup now.

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Yankees OF Cody Bellinger vs. Red Sox: 1.5 Hits + Runs + RBIs

• The left-handed-hitting Bellinger may have little worry about facing the lefty Suarez; he’s been better against southpaws with a .371 wOBA compared to a .368 wOBA against righties.
• Suarez’s 22.2% induced whiff rate, which ranks in the 22nd percentile, is a significant disadvantage compared to Bellinger’s 17.0% whiff rate (86th percentile).
• Bellinger’s discipline at the plate could play a role, as his 14.4% walk rate ranks in the 88th percentile, going against Suarez, whose 8.0% walk rate is in the 59th percentile.
• Suarez throws the sinker and cutter for a combined 47.6% of his pitches, and Bellinger is stellar against both with a .417 wOBA against the sinker and a .476 wOBA against the cutter.

Add Cody Bellinger to your PrizePicks Lineup now.

Make Red Sox vs. Yankees Picks on PrizePicks

One of baseball’s biggest rivalries is renewed with the Red Sox traveling to the Bronx to take on the Yankees. Boston got the upper hand on Friday, and now it will be up to one of the Yankees' young starters, Will Warren, to tie the series on Saturday night.

Don’t wait until the first pitch happens — make your Red Sox vs. Yankees picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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