On Wednesday at the US Open, Mirra Andreeva will take on Coco Gauff in the final quarterfinal match on the women’s side.
Still just 19 years old, Andreeva broke through with her first major title at this year’s French Open, and this is the furthest she’s ever advanced at the US Open. Gauff won this title in 2023 and is riding a 10-match win streak dating back to her run to the Cincinnati Open title this summer.
Below, we’ll break down our Mirra Andreeva vs. Coco Gauff prediction, including recent form, match analysis, and a PrizePicks pick. The match is slated to start at approximately 12:30 p.m. ET on ESPN.
Make your US Open predictions on PrizePicks for Wednesday’s match now!
{{tennis_banner="/style-system/ui-components-playbook"}}
Mirra Andreeva vs. Coco Gauff Prediction, Favorite for the US Open Quarterfinals
Below are the payouts for who will win Wednesday’s Andreeva vs. Gauff match, via PrizePicks.
Tennis on PrizePicks got its biggest upgrade yet just in time for the US Open. Users can now combine a player to win outright with Player Picks, including aces, total games won, and more! Click here for more information.
On PrizePicks Team Picks, a 2x payout represents a return of $200 on a $100 entry (or $20 on $10). A lower payout multiplier signals a higher implied probability of that result based on user picks.
Payouts are live at the time of writing and are subject to change. Tennis winner markets are available in 36 states.
Mirra Andreeva vs. Coco Gauff Prediction for US Open – Wednesday, September 9
Match Winner Payouts: Andreeva 2.56x | Gauff 1.44x
Tournament Round: Quarterfinals
2026 Record Entering the US Open: Andreeva 40-13 | Gauff 40-13
Head-to-Head Record: Gauff leads 5-0
Scheduled Time: 12:30 p.m. ET
How to Watch: ESPN
Coco Gauff has not only won 10 consecutive matches, but she’s 18-2 dating back to the beginning of Wimbledon. Her only losses over that span have come against top-10 players Karolina Muchova and Elena Rybakina.
In the round of 16, Gauff faced up-and-comer Iva Jovic in a highly anticipated all-American bout, and she passed the test with flying colors, defeating the 18-year-old 6-1, 6-4.
Gauff was relentless on return, winning 56% of her receiving points and converting five of her 11 break point chances.
The American has been on a roll, winning all four US Open matches without dropping a set. In fact, over her 10-match winning streak, the last nine have been in straight sets.
Up next for Gauff is another teenager in Mirra Andreeva.
The 19-year-old Russian had previously never advanced past the third round at the US Open, but she’s no stranger to making deep runs in Grand Slams, as this will be her fifth major quarterfinal. She got over the hump with her first Grand Slam title at the 2026 French Open, and many expect it will be the first of many for the teenage phenom.
Andreeva’s first three matches mostly went without a hitch in straight sets, but she did have to navigate an upset bid by Anastasia Potapova in the round of 16 before emerging with a 5-7, 6-4, 6-3 win. The match was unfortunately marred by Potapova injuring her knee in the last game, contributing to her losing the match’s final three points.
While Andreeva has enjoyed a fantastic season, she’s been unable to figure out Gauff in her young career, losing all five matches they’ve played. They met earlier this year in Rome, and Gauff emerged victorious in three sets.
Per Tennis Abstract’s Elo ratings, Gauff has a 67.2% chance to defeat Andreeva. The American has been scorching hot this summer, and the head-to-head record against her opponent will only further fuel her as she attempts to reach her second US Open semifinal.
Make your Andreeva vs. Gauff US Open prediction on PrizePicks now!
{{tennis_banner="/style-system/ui-components-playbook"}}
Mirra Andreeva vs. Coco Gauff Pick for the US Open on Wednesday
Note: In PrizePicks tennis fantasy scoring, players earn 10 points to start (match played), games won/lost are +1/-1, sets won/lost at +3/-3, aces are 0.5, while double faults count for -0.5.
Over Gauff’s 10-match win streak, she’s scored 19, 22, 22.5, 23, 23, 22, 22, 18, 18.5, and 23 fantasy points.
Gauff hasn't been pushed to a deciding set since August 16.
In the American’s five wins over Andreeva, she’s won 10 of 12 sets. Their only hard-court match came at the 2023 US Open, which Gauff won 6-3, 6-2.
Gauff has served well through four rounds, as no opponent has broken her more than twice. She’s dramatically reduced her double faults compared to a year ago, committing a manageable 16 total so far.
Gauff Pick – 15.5 Fantasy Score
Pick Gauff to win + fantasy score on PrizePicks for higher payouts!
Make US Open Predictions Today on PrizePicks
Coco Gauff has been nearly untouchable this summer and has historically had Mirra Andreeva's number. Can Andreeva still give Gauff some trouble?
Don’t wait until Wednesday’s matches start — make your US Open predictions on PrizePicks now.
Pick your players, predict More or Less on their stats like games won or aces, or make match winner predictions with PrizePicks, available in 36 states!
Stay locked in on Playbook for daily US Open predictions, tennis picks, and PrizePicks analysis throughout the tournament.
Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state.Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results.Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.
