Week 5 in college football delivered down-to-the-wire matchups, with none better than Oregon getting the road win in an overtime battle against Penn State.
As we move onto Week 6 on Saturday, these games could bring the same energy. Below, we'll give you the top CFB DFS picks for Saturday's games in Week 6, including PrizePicks picks today in the marquee college football matchups.
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No. 10 Alabama and QB Ty Simpson just won a battle vs. Georgia. Now the Tide get another ranked opponent at home vs. No. 18 Vanderbilt at 3:30 p.m. ET on ABC. It's a chance to the Crimson Tide to get revenge for their upset at the hands of the Commodores last year.
One of the biggest rivalries in college football is renewed as No. 3 Miami travels to Tallahassee to battle No. 18 Florida State at 7:30 p.m. ET on ABC. It is the first time since 2016 that both teams come into this game ranked inside the top 25 in the AP Poll.
PrizePicks is the simplest way to win real money with your CFB picks this Saturday and every week; just pick your players, predict More or Less on their stats, and cash in when your picks are correct.
Let's dive into the top college football DFS picks for Saturday, October 4.
Saturday CFB DFS Picks for Week 6
Here are the top CFB DFS picks for Saturday in Week 6 of college football, including PrizePicks picks for Alabama vs. Vanderbilt and Florida vs. Texas.
Use this analysis to build your PrizePicks CFB Lineups for Saturday's Week 6 games.
Florida QB DJ Lagway Projection: 193.5 Passing Yards
No. 9 Texas vs. Florida Pick – 3:30 p.m. ET
- In Week 5, Florida QB DJ Lagway threw for just 61 yards against a Miami pass defense that is 46th in defensive pass EPA (0.010).
- Texas is 14th in defensive pass EPA (-0.32).
- Opponents have thrown for under 200 passing yards against the Longhorns in three of four games this season.
- The sophomore QB is 96th in yards per pass attempt (5.7).
- Texas is 3rd in opponents' yards per pass attempt allowed (4.9) and ninth in pass yards allowed per game (152.3).
- The Gators are 100th in sacks allowed per game (2.8) and 66th in pass block grade, per PFF.
- The Longhorns are 45th in sacks per game (2.3), which creates a mismatch up front.
Alabama QB Ty Simpson Projection: 298.5 Passing Yards
No. 18 Vanderbilt vs. No. 10 Alabama Pick – 3:30 p.m. ET
- New Alabama QB Ty Simpson is coming off throwing for 276 yards and 3 TDs against Georgia on the road.
- He is now averaging 329 yards over his last two games.
- The junior is one of seven quarterbacks to have at least a 69% completion rate with a minimum of 125 pass attempts.
- Vanderbilt is 124th in completions allowed per game (25.0).
- The Crimson Tide QB has the sixth-highest yards per attempt (9.7).
- The Commodores are 88th in defensive pass EPA (0.88).
Baylor RB Bryson Washington Projection: 90.5 Rushing Yards
Kansas State vs. Baylor Pick – 12 p.m. ET
- Baylor RB Bryson Washington has more than 90 rushing yards in three of his last four games.
- The Bears RB is seventh in carries (93) and tenth in rushing yards (492).
- Kansas State is 114th in rushing yards allowed per game (201.5).
- According to PFF, Washington is 16th in missed tackles forced (19).
- 13 players on the Wildcats defense have at least 2 missed tackles, per PFF.
- The sophomore Washington has the sixth-most runs of 10+ yards.
- KSU is 114th in rushes of 10+ yards allowed (26).
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Florida RB Jadan Baugh Projection: 63.5 Rushing Yards
No. 9 Texas vs. Florida Pick – 3:30 p.m. ET
- Florida RB Jadan Baugh has not rushed for more than 50 yards against a Power Four opponent this year.
- Texas is sixth in PFF run defense grade (92.6).
- Out of Baugh’s nine runs exceeding 10 yards, seven occurred against non-Power Four teams.
- The Longhorns have allowed the second-fewest runs of 10+ yards (3).
- Texas is 22nd in opponents' rush play percentage (45.71%).
- Texas is giving up just 3.19 yards per rush — fourth best in the nation.
Duke WR Cooper Barkate Projection: 65.5 Receiving Yards
Duke vs. California Pick – 10:30 p.m. ET
- Duke WR Cooper Barkate is 14th in receiving yards (409) in the country.
- Of the 16 wide receivers with at least 400 receiving yards, Barkate is third with 19.5 yards per reception.
- The Blue Devils senior has the second-most 20+ yard receptions (9).
- Cal is 52nd in 20+ yard receptions allowed (12).
- Barkate will likely match up against Cal DB Hezekiah Masses, who is allowing 15.8 yards per reception.
Texas A&M WR Mario Craver Projection: 81.5 Receiving Yards
Mississippi State vs. No. 6 Texas A&M Pick – 7:30 p.m. ET
- Texas A&M WR Mario Craver is seventh in the country with 477 receiving yards on a dynamic Texas A&M offense.
- Of the 16 wide receivers with 400+ receiving yards, the Aggies WR has the third-fewest catches (24).
- Craver is one of two wide receivers to have receptions of 70+ and 80+ yards.
- Mississippi State is 22nd in defensive pass EPA, but it has only faced one FBS program inside the top 50 in pass EPA.
- That was in Week 5 against Tennessee, where the Bulldogs allowed two wide receivers to go over 100 receiving yards.
Make Week 6 CFB DFS Picks on PrizePicks
With two matchups between top 25 teams on Saturday, Week 6 of college football will produce some memorable matchups as we roll into conference play with some huge implications in the standings.
Whether you're watching SEC matchups of Vanderbilt vs. Alabama or Texas A&M vs. Mississippi State, PrizePicks is the best way to cash in on your college football picks.
Just pick your players — including Mario Craver and Ty Simpson — predict More or Less on their stat projections, and get paid when your picks are correct on PrizePicks CFB.
Stay locked in on the Playbook for more CFB DFS picks and college football predictions throughout the 2025 season.
