Best NFL Anytime TD Scorer Predictions for Afternoon Games – Derrick Henry, More

Through the first two weeks of the NFL season, we’re seeing plenty of high-scoring games, with 12 teams averaging 25 points or more this season. A couple of those electric offenses will be featured in the late window on Sunday.

Below, we'll highlight our best NFL anytime TD scorer predictions for games kicking past 4:00 p.m. ET in NFL Week 3, including three players who could reach the end zone for picks on PrizePicks.

Make your NFL Anytime TD picks for Week 3 on PrizePicks now.

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Best Week 3 NFL Anytime TD Scorer Picks for PrizePicks

The late window has a few games that could see a lot of points, including Ravens vs. Cowboys, Raiders vs. Saints, and Cardinals vs. 49ers. All of these games feature dynamic playmakers that can change the matchup with one trip to the end zone.

Anytime TDs on PrizePicks include rushing, receiving, recoveries, and returns. PrizePicks often list Anytime TDs as Demons and Goblins, meaning users can only select "More." For standard projections, users can select “More” or “Less.”

Demons are tougher to win but are the only way to get higher payouts. Meanwhile, Goblins are lower than a standard projection, but they are easier to win, so there’s a lower payout.

Here are the top NFL Week 3 anytime TD scorer picks to target this weekend, headlined by Derrick Henry, Devaughn Vele, and Trey McBride.

Ravens vs. Cowboys Anytime TD Scorer Prediction – 4:25 p.m. ET

Ravens RB Derrick Henry: 0.5 Anytime TDs

Just like every year, we expect Henry to regress as he gets older, but he remains one of the NFL's best running backs. The 2026 season is no exception, as he is leading the league in rushing TDs (4) and ranks third in rushing yards (212). 

The Ravens have a new coaching staff led by head coach Jesse Minter, but the offensive scheme remains the same: run the ball. Over the previous three seasons, they ranked first or second in rushing play percentage; they’ve dropped slightly to eighth (49.1%). 

When the Ravens enter the red zone, they lean on Henry, who leads the NFL with 7 goal-to-go carries. He has excelled in that situation, leading the league in rush EPA (+3.9) and TDs (3).

Henry is facing the Cowboys, who allowed 151 rushing yards and 2 TDs to Henry in 2024's head-to-head matchup. The Dallas run defense is struggling by allowing the fourth-most yards per carry (5.0) and EPA per rush (+0.09).

Add Derrick Henry + Ravens to win on PrizePicks.

Raiders vs. Saints Anytime TD Scorer Prediction – 4:25 p.m. ET

Saints WR Devaughn Vele: 0.5 Anytime TDs (Demon)

The Saints are emerging as a contender this season after finishing last in the NFC South last year. In Week 1, they erased a 21-point halftime deficit against the Lions. In Week 2, they came back from an 8-point deficit in the fourth quarter to beat the Ravens.

Saints QB Tyler Shough is a key reason for the success. The sophomore quarterback has been excellent and comes into Week 3 leading the league in passing yards (664).

That is with the help of his wide receivers, including Chris Olave, who ranks fourth in the league in receiving yards (268) and second in reception EPA (+19.4).

The Saints expected 2026 first-round WR Jordan Tyson to be the second option in this offense, but he suffered a hamstring injury in training camp and is currently on IR.

In Tyson’s absence, Vele is emerging as the WR2 in the Saints offense and is second on the team in receiver yards (133).

This week presents a favorable matchup against the Raiders. Vele has been productive when lined up in the slot, ranking fourth in receiving yards (94) and sixth in catches (6). 

When their opponents target slot receivers, the Raiders rank 30th in yards per reception (12.4), and their primary NB Taron Johnson is allowing 13.7 yards per reception. 

Add Devaughn Vele + Saints to win on PrizePicks.

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Cardinals vs. 49ers Anytime TD Scorer Prediction – 4:05 p.m. ET

Cardinals TE Trey McBride: 0.5 Anytime TDs

McBride is one of the top tight ends in football, leading the position in receptions (17) while sitting fourth in receiving yards (136). 

He’s also the guy Cardinals QB Jacoby Brissett looks for on almost every dropback, as McBride leads the team in target share (36.7%), red zone target share (66.7%), and goal-line target share (100%). That is correct; McBride has all the Cardinals' targets at the goal line.

This is an important matchup for Arizona as it faces its NFC West rival, the 49ers. San Francisco’s offense has been excellent this season and is fourth in the league in points per game (31.0). Don't be surprised if the Cardinals trail most of the game and have to air it out, which could mean plenty of targets for McBride. 

After not finding the end zone in his first four career games against the 49ers, he has scored in his last three meetings with San Francisco.

Add Trey McBride + Cardinals to win on PrizePicks.

Make NFL Week 3 Picks on PrizePicks

The late window in Week 3 features a few marquee matchups to watch, including some of the league’s top teams. These games present a great opportunity to tail some of the NFL’s top players to find their way into the end zone.

Don’t wait until kickoff — make your NFL Week 3 picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats (like Anytime TDs), and cash in if you’re right. With Team Picks, you can make predictions on NFL game winners, spreads, and over/unders, now available in 36 states.

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