Best Giants vs. Rams Anytime TD Scorer Predictions for Monday Night Football

After an action-packed Week 1, the NFL hasn’t brought nearly the same level of punch in Week 2. With that said, some clubs have still managed to stuff the stat sheets from Thursday through Sunday. What could Monday have in store? 

Kicking off at 8:15 p.m. ET, the New York Giants vs. Los Angeles Rams game features teams whose offenses couldn’t have fared differently a week ago. New York rolled to a victory over the Dallas Cowboys, while Los Angeles got thumped by the San Francisco 49ers in Australia.

With the Giants boasting an electric QB-RB combination and the Rams looking to return to form as one of the top offenses in the sport just last year, who could find pay dirt in this one? 

Below, we'll highlight our best Giants vs. Rams anytime TD scorer predictions for Monday Night Football, including three players who could reach the end zone.

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Giants vs. Rams Anytime TD Scorer Picks for Monday Night Football – September 21

Monday Night Football presents a classic clash of reputation vs. recent performance. Head coach Sean McVay’s L.A. crew, for instance, finished the 2025 regular season ranking second in EPA per play (0.149) and first in success rate (52.2%), via RBSDM. Entering this outing, John Harbaugh’s New York squad is second (0.363) and first (59.1%), respectively, in 2026.

Banking on the Giants to sustain this level of success or the Rams to struggle at this rate moving forward would be foolish, but meeting in the middle could still produce some touchdowns. 

Anytime TDs on PrizePicks include rushing, receiving, recoveries, and returns. PrizePicks often list Anytime TDs as Demons and Goblins, meaning users can only select "More." For standard projections, users can select “More” or “Less.”

Demons are tougher to win but are the only way to get higher payouts. Meanwhile, Goblins are lower than a standard projection, but they are easier to win, so there’s a lower payout.

Giants QB Jaxson Dart vs. Rams: 0.5 Anytime TDs (Demon)

• Dart had a 2026 debut to remember, boasting a video game-like 74.4% success rate. 
• The Giants are last among all 32 NFL clubs in neutral pass frequency and produced 0.423 EPA/carry in those scenarios against the Cowboys.
• Dart finished 2025 third for QB rushing yards with 487 and rush EPA with 31.96, according to SumerSports. 
• No QB had more rushing yards on designed runs than the 2025 first-round pick’s 165 in his debut campaign. Per NFL Pro, Los Angeles ceded the fourth-most yards per carry (5.6) on such plays. 
• The Rams failed to contain the 49ers’ ground attack in Week 1 and, entering Monday’s play, are 30th in rush EPA/play (0.142) and 31st in success rate (53.6%) on defense.

Add Jaxson Dart + Giants to win to your PrizePicks lineup now.

Rams RB Kyren Williams vs. Giants: 0.5 Anytime TDs (Goblin)

• Williams scored a TD in Week 1 and is coming off a year in which he averaged 3.06 yards after contact per attempt and forced 51 missed tackles (Pro Football Focus). 
• Via Sharp Football Analysis, Williams logged 77.8% of L.A.’s red-zone snaps vs. the 49ers after being present for 69.2% of them a season ago. 
• Inside the 10-yard line, Los Angeles gave 75% of its rushing tries to Williams in Australia, putting him in the top 15 leaguewide. 
• L.A. was tied for the lowest pass rate over expected in Week 1 at -17.3%, per nfelo. While it’s unlikely that McVay abandons airing it out to that degree on Monday, Williams could still receive plenty of opportunities on the ground.  
• New York’s run defense was horrific last season, ranking 32nd in rush EPA/play allowance at 0.109. 

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Add Kyren Williams + Rams to cover the spread to your PrizePicks lineup now.

Rams WR Davante Adams vs. Giants: 0.5 Anytime TDs (Goblin)

• Adams was football’s premier red-zone receiving threat in 2025, leading the sport with 12 TDs on 13 receptions. 
• The wily veteran ranked 15th in WR target share a season ago at 24.78%, sandwiched between Carolina Panthers star Tetairoa McMillan and former Washington Commanders funnel Deebo Samuel. 
• Los Angeles put Adams in the slot on 39.1% of his Week 1 snaps, which would be the second-highest figure of his career if it held up for a full season. That could earn him some free releases, thus giving him room to operate post-catch. 
• Despite now being 33 years old, Adams ranked in the top 10 among all WRs in Fantasy Points Data’s average separation score in Week 1.
• WR Puka Nacua continues to nurse a hip injury that held him out of Friday and Saturday’s practices. Even if he’s available for MNF, Adams might be asked to absorb some of his receiving volume. 

Add Davante Adams + Rams to win to your PrizePicks lineup now.

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As New York aims to continue producing results on offense, Dart figures to be a big-time part of that effort. Meanwhile, Nacua’s injury status could place added pressure on players like Williams or Adams to step up for the Rams in a sneakily important contest. 

Don’t wait until kickoff — make your Giants vs. Rams picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats (including anytime TDs), and cash in if you’re right. With Team Picks, you can make predictions on NFL game winners, spreads, and over/unders, now available in 36 states.

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