Tired of running out the same tired team in your fantasy football league every week? Daily Fantasy Sports — or DFS — is what you’re looking for. With NFL DFS, you can take advantage of the best matchups every week and build a lineup with any NFL player you like.
Think Patrick Mahomes is going off this week? Add his passing yards to your lineup. Know Saquon Barkley is getting in the end zone? You can pick him to score a touchdown on PrizePicks.
This season, there’s no better place to play NFL DFS than on PrizePicks. It’s DFS, without the fluff. Just you vs. the projections.
No leagues, no draft, no season-long commitment, no salary caps — just weekly action to win real money by predicting More or Less on NFL player stats like yards, touchdowns, field goals, and much more.
You don’t need to be an NFL expert to win on PrizePicks. You just need to know a few players, how to spot trends, and play smart.
In this guide, we’ll explain how NFL DFS works on PrizePicks, how it compares to traditional DFS platforms, what stats you can play, and DFS strategy to build your Lineups.
What is NFL DFS on PrizePicks?
NFL DFS on PrizePicks is the best way to get real money action every week of the NFL season. Instead of building a full roster or entering a contest vs. thousands of lineups, you simply lock in 2 to 6 picks based on player stats, predicting More or Less on each one.
If your picks are correct, you’ll win real cash with every lineup. It’s that simple.
With NFL DFS on PrizePicks, you simply lock in 2 to 6 picks on player stats, predicting More or Less.
It’s a cleaner, faster, more confident way to get the thrill of fantasy football — with a new team every week. No drafts or salary caps. Just you, the numbers, and your predictions.
NFL DFS on PrizePicks vs. Traditional DFS (DraftKings, FanDuel)
PrizePicks is not like every other DFS site. Wondering how it stacks up against other DFS platforms like DraftKings and FanDuel? Here’s a quick breakdown of what makes PrizePicks different, and why so many fans make their NFL predictions on PrizePicks every week.
How Does PrizePicks NFL DFS Work?
Playing NFL DFS on PrizePicks is simple. Pick your players. Predict More or Less on their stats. Then watch them play. It’s that easy.
Here’s a step-by-step to getting started on PrizePicks and how to make your NFL DFS lineup after you’ve created your account and claim your free $50 bonus for signing up with promo code PLAYBOOK.
- Choose Your Sport: Select NFL at the top of PrizePicks app.
- Pick your Players: Browse available player projections, or use the search to see all projections available for a player.
- Choose your Stat: Select a projected stat like passing yards, rushing yards, or Rush+Rec TDs.
- Predict More or Less: Predict whether the player will have More or Less of their projected stat.
- Build your lineup: Add 2-6 players to your lineup, then choose between Power Play (all picks must be right) or Flex Play (can miss 1-2 and still win).
- Submit your lineup and watch: Let the fun begin. Sit back and sweat your lineup in real time.
Types of NFL Projections on PrizePicks
Here are the stats that are available to pick More or Less on a weekly basis during the NFL season. On the PrizePicks NFL board, you’ll find several other stat projections that you won’t find elsewhere, like combos between two quarterbacks’ yards or combos with either player to score a touchdown.
PrizePicks also offers first half (1H), first quarter (1Q), and second half (2H) boards if you're looking for high-paced action, as well as live full-game boards on most major stat categories.

Quarterback Stat Projections:
- Pass Attempts & Completions
- Passing Yards
- Passing TDs
- Rushing Yards
- Longest Completion
- Fantasy Score
Running Back Stat Projections:
- Rush Attempts
- Rush Yards
- Rush Yards in First 5 Attempts
- Longest Rush
- Receptions
- Receiving Yards
- Rush+Rec TD
- Fantasy Score
Wide Receiver / Tight End Stat Projections:
- Receptions
- Targets
- Receiving Yards
- Longest Reception
- Receiving Yards in First 2 Receptions
- Rush+Rec TD
- Fantasy Score
Kicking / Punting Stat Projections:
- FG Made
- FG Attempts
- FG Yards
- Kicker Fantasy Score
- Kicking Points
- Longest FG Made Yards (Combo)
- Shortest FG Made Yards (Combo)
- PAT Attempts
- Punts Inside the 20
- Gross Punt Yards
- 50+ Yard Punts
Defensive Stat Projections:
- Total Tackles
- Sacks
- Tackle for Loss
- Interceptions
NFL DFS Strategy on PrizePicks
Getting wins in NFL DFS on PrizePicks starts with a solid strategy. With PrizePicks, you can get action on every game, every week — it just depends on how you want to build your lineups.
The good news? You don’t need to be an NFL expert to win on PrizePicks. You just need to know a few players, how to spot trends, and play smart.
Player Research & Last 5 Games Tool

Use the built-in Last 5 Games tool on each player card to see trends and recent performance. View these stats by clicking the bar chart in the top left of the player card.
Additionally, doing player research with resources like PFF is a great way to dive deeper into every game.
Find Weekly Expert Picks, Predictions on Playbook
Want to make your lineup building easier? Tap into expert NFL picks on Playbook every week. On Playbook, you’ll find industry experts give their take on every game, with picks, predictions, and statistical insights to help you build your lineup.
Bookmark the Playbook NFL home page here to check out the picks and predictions every week.
Less Picks = Easier Wins
You can win up to 2000x on a single lineup on PrizePicks — some of the highest multipliers in all of NFL DFS, but only by using 6-Pick lineups. Sometimes, it’s not about how much you can win, but rather, just securing the dub.
Instead of 6-Pick lineups, try 2-Pick and 3-Pick Power Play lineups to increase your shot to cash in on your predictions. Even for the experts, hitting on six picks isn’t easy — but 2- and 3-Picks are very attainable.
These lineups offer lower payouts, but much higher hit rates.
Using Power vs. Flex Play Lineups

Once you build your lineup, you have two options:
- Power Play: Bigger payouts, but you must hit every pick.
- Flex Play: Lower payouts, but you can still cash in even if one or two picks miss, depending on your lineup size.
Feel free to mix and match based on the confidence of your lineup. For example, for a full Sunday 1 p.m. slate, you may love your lineup, picking out the best projections the board has to offer. But with a lineup with less game action — like Sunday Night Football only — it may be safer to go with the Flex Play, since your athlete options are more limited.
Flex Plays are a way to play it safe, while Power Plays have more upside, with the highest payouts offered.
Why Play NFL DFS on PrizePicks?
PrizePicks is built for football fans who want to get in on the real money action without the stress of managing full rosters. For the ones who trust their instincts. For the ones who know what’s coming next. No more competing against thousands of entries — it’s you vs. the projections to win cash.
Whether you’re picking your favorite players or chasing stats without the fandom, PrizePicks is the fastest and most exciting way to make your NFL predictions count this season.
Why PrizePicks is the best place to play NFL DFS
- No one to compete against — just you vs. projections
- Choose a new team every week
- Easy set-up and quick payouts
- Not research-intensive — build a lineup in 60 seconds!
- Free $50 bonus just for signing up with promo code PLAYBOOK
- Real money prizes on simple More or Less picks on any player
- 24/7 access with projections and stats always on deck
- Free picks, player discounts, and more promotions weekly
Play NFL DFS on PrizePicks Every Week
Ready to put your NFL predictions to the test this season and show your friends what’s good? Want to build your ideal fantasy team every week with no hassle and no competition but yourself? NFL DFS on PrizePicks is the way to go.
Whether you’re new to fantasy football, or a DFS vet looking for a fresh format, there’s never been a better way to play than on PrizePicks.
With promotions running all season long, you’ll never run out of excitement this NFL season. Give the tedious full roster lineup building a rest this NFL season, and jump into PrizePicks, where you only need two picks to win real money with your NFL predictions.