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The Week 10 NFL Sunday slate of games has 11 matchups on the docket, beginning with the New England Patriots and Detroit Lions clashing in Germany at 9:30 a.m. ET. Luckily for fans, they can get in on the action with endless player pick options on PrizePicks.
With plenty of stars in action in Week 10, which players stand out across Sunday’s contests?
Below, we'll bring you our top NFL DFS picks for PrizePicks, where you can predict More or Less on player stats to earn real money!
Make your Week 10 NFL predictions and picks on PrizePicks!
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Week 10 NFL DFS Picks for PrizePicks – Sunday, November 15
Here are the top Week 10 NFL DFS picks to target on PrizePicks Player Picks for Sunday, November 15. Today’s NFL picks include Tyler Shough, Zach Charbonnet, George Kittle, Tyler Warren, and Blake Corum.
Stats in this article are courtesy of PFF or Sumer Sports unless stated otherwise.
Saints QB Tyler Shough vs. Panthers: 252.5 Pass Yards
- Shough has thrown for at least 255 yards in five of his first eight starts in 2026.
- Plus, Shough has posted 255 or more passing yards in four of his first five home starts this season, with the lone miss coming against a daunting Minnesota Vikings defense.
- Across the first nine weeks, the New Orleans Saints are ninth in neutral pass rate (54.9%).
- The Carolina Panthers’ defense is also 23rd in dropback EPA (0.13) and 26th in dropback success rate allowed (48.5%).
Pick Tyler Shough + Saints to cover the spread on PrizePicks!
Seahawks RB Zach Charbonnet vs. Raiders: 59.5 Rush Yards
- Charbonnet rushed for 77 yards in Week 9 in just his second game back from a season-ending knee injury.
- In the Week 9 victory over the Arizona Cardinals, Charbonnet led the Seattle Seahawks’ RBs in snaps (37) and rushing attempts (16).
- Rookie RB Jadarian Price logged 24 snaps and 9 attempts as the clear backup to Charbonnet.
- The Las Vegas Raiders’ defense is 24th in rushing EPA (-0.07) and rushing success rate allowed (42.2%).
Pick Zach Charbonnet + Seahawks to win on PrizePicks!
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TE George Kittle vs. Cowboys: 62.5 Receiving Yards
- Kittle has registered at least 69 receiving yards in five of his last seven outings.
- Even with the San Francisco 49ers acquiring WR Keenan Allen, the team is still enduring multiple offensive injuries.
- Among the 35 TEs with 25 or more targets this year, Kittle has the seventh-most yards per reception (12.7) and the second-most yards per route run (2.40).
- The Dallas Cowboys’ defense currently ranks 28th in dropback EPA (0.19) and 27th in dropback success rate allowed (49.0%).
Pick George Kittle + 49ers to win on PrizePicks!
Colts TE Tyler Warren vs. Dolphins: 42.5 Receiving Yards
- Warren has achieved at least 44 receiving yards in two of his last three starts.
- The Indianapolis Colts offloaded Allen and WR Josh Downs at the trade deadline, leaving more targets for Warren.
- Warren was already recording the fifth-highest target share among TEs (23.3%) before Allen and Downs’ departures.
- The Miami Dolphins’ defense is 31st in dropback EPA (0.25) and 32nd in dropback success rate allowed (52.9%).
Pick Tyler Warren + Colts to win on PrizePicks!
Rams RB Blake Corum vs. Cardinals: 57.5 Rush Yards
- Corum has rushed for 58 or more yards in three straight contests.
- Even with RB Kyren Williams still considered the starting RB for the Los Angeles Rams, Corum leads all RBs with at least 50 attempts in EPA/rush (0.17) and rushing success rate (58.1%).
- With the Rams shorthanded at WR, Sean McVay can lean on Corum and the team’s rushing attack.
- Although the Cardinals are solid against the run, run-stopping DT Roy Lopez is uncertain to play on Sunday.
Pick Blake Corum + Rams to win on PrizePicks!
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Make Week 10 NFL Picks on PrizePicks
Week 10 of the 2026 NFL season provides fans with plenty of advantageous matchups to target on PrizePicks. Of the player picks available, Shough, Charbonnet, Kittle, Warren, and Corum are all in favorable spots for NFL Week 10.
Ahead of Sunday’s action, it's time to lock in your NFL picks on PrizePicks to win real money if you're right. Just pick your players, predict More or Less on their stats, and cash in on your predictions when you're right.
With PrizePicks Team Picks, make your predictions on game winners, spreads, and over/unders — or combine one with players for even higher payouts.
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