Astros vs. Rangers Prediction, MLB Picks for Thursday, May 28

The Houston Astros vs. Texas Rangers game is set for first pitch at 8:05 p.m. ET on Thursday, May 28, with the Rangers entering as favorites with a 1.66x payout to win, via PrizePicks. 

The Astros (25-32) seek their second series victory over the Rangers (25-30) this month. Houston captured two of the first three games in this four-game series, capped off by a 4-3 triumph on Wednesday.

It’s the final contest of a 10-game road trip for Houston, who has won five of six games since dropping two of three at Minnesota.

Below, we'll break down our Astros vs. Rangers prediction and picks for Thursday's MLB game, including the winner, over/under, and key player picks for PrizePicks.

Make your Astros vs. Rangers picks on PrizePicks now.

{{mlb_offer_banner="/style-system/ui-components-playbook"}}

Astros vs. Rangers Prediction, Winner, Over/Under – Thursday, May 28

The Astros combined on a no-hitter in Monday’s 9-0 shutout of the Rangers, marking the third time Houston held Texas to 1 run or fewer this month. Texas rebounded on Tuesday with an 8-run outburst in the opening inning of a 10-7 triumph.

Houston escaped with a 4-3 victory on Wednesday, as right-hander Mike Burrows tossed 7 innings for his first win in three starts. Astros DH Yordan Alvarez went deep twice to move his home run total to 20 this season.

Since May 15, the Rangers own a 4-8 record, while the Astros have turned it around to win eight of their past contests. In the last two weeks, Houston is hitting .208, which is the third-worst batting average in this split. However, the Astros are limiting opponents to a .188 average, which is the second-lowest mark in MLB, behind only the Dodgers.

Texas sits 24th in slugging percentage (.374), while scoring 2 or fewer runs nine times in the last 12 games. Even following the huge first inning on Tuesday, the Rangers posted 2 runs in the final seven innings.

Three of the star middle infielders in this Lone Star matchup are sidelined with Houston 2B Jose Altuve and SS Carlos Correa, along with Texas SS Corey Seager out with injuries.

Astros vs. Rangers Winner, Over/Under – Thursday, May 28

The Rangers enter Thursday’s game as a home favorite against the Astros, returning a 1.66x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Astros vs. Rangers game on PrizePicks.

• Spread: Texas Rangers -1.5 (2.5x payout)
• Over/Under: 7.5 (2.04x payout on Over)
• Game Winner Payout: Astros 2.08x | Rangers 1.66x

Make your Astros vs. Rangers prediction on the winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

Astros vs. Rangers Prediction on Winner – 5/28/26

Here are the key game stats and trends behind our Astros vs. Rangers prediction on the winner for Thursday, May 28.

Lock in your Astros vs. Rangers prediction on PrizePicks before the first pitch.

• The Astros have captured seven of the last nine matchups against the Rangers since last September.
• Houston SP Spencer Arrighetti is limiting opponents to a batting average of .169, along with a whiff rate of 27.7%, per Baseball Savant.
• The Rangers whiff at the fourth-highest rate in MLB at 27.4%, and that jumps to 30.4% against right-handers.
• Texas has closed its home series out on a high note, winning in five of the past six opportunities.
• Houston is 6-1 in Arrighetti’s seven starts in the first five innings. He has held opponents to 1 run or less in all five opening frames.

Astros vs. Rangers Player Picks, Stats for PrizePicks – 5/28/26

Here are the top Astros vs. Rangers picks to target on PrizePicks for Thursday, May 28. Today’s MLB picks for PrizePicks include SP Nathan Eovaldi and DH Yordan Alvarez.

Astros DH Yordan Alvarez vs. Rangers: 1.5 Hits + Runs + RBIs

• Alvarez is hitting a scorching .522 (12 of 23), including 5 extra-base hits and 6 RBI, against Eovaldi.
• He's 6 for 12 with 5 home runs, 5 runs scored, and 8 RBIs in this series.
• The Houston slugger is in the 99th percentile in xwOBA (.479) and xSLG (.723) against right-handed pitchers.
• Alvarez went five consecutive games staying below this projection before eclipsing it in each of the past three contests.

Add Yordan Alvarez to your PrizePicks Lineup now.

{{mlb_offer_banner="/style-system/ui-components-playbook"}}

Rangers SP Nathan Eovaldi vs. Astros: 6 Strikeouts

• Eovaldi owns excellent chase (37.9%) and whiff rates (31.9%), each ranking in the 90th percentile or better.
• The right-hander produced 6 Ks in his last start against the Angels, ending a three-start streak with 7 or more strikeouts.
• Eovaldi tossed 7 scoreless innings and struck out 8 in an 8-0 shutout of the Astros on May 17.
• Current Houston batters are hitting .252 against Eovaldi, including 1B Christian Walker going 6 of 16 with a pair of home runs. 

Add Nathan Eovaldi to your PrizePicks Lineup now.

Make Astros vs. Rangers Picks on PrizePicks

The battle of Texas will be hot and heavy tonight, with the Rangers looking to split this four-game set. Will Texas bounce back, or will Houston continue its domination of the in-state rivalry?

Don’t wait until lock — make your Astros vs. Rangers picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

Stay locked in on Playbook for daily MLB predictions, picks, and news every day all the way through the 2026 World Series.