The Cincinnati Open quarterfinals get underway on Thursday, and Amanda Anisimova vs. Jessica Pegula figures to be one of the slate’s highlights in an all-American, top-10 matchup.
Below, we’ll break down our Amanda Anisimova vs. Jessica Pegula prediction, including recent form, match analysis, and a PrizePicks pick. The match is slated to start at 1:00 p.m. ET on Tennis Channel.
Make your Cincinnati Open predictions on PrizePicks for Thursday’s match now!
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Amanda Anisimova vs. Jessica Pegula Prediction, Favorite for the Cincinnati Open Quarterfinals
Below are the payouts for who will win Thursday’s Anisimova vs. Pegula match, via PrizePicks Team Picks.
On PrizePicks Team Picks, a 2x payout represents a return of $200 on a $100 entry (or $20 on $10). A lower payout multiplier signals a higher implied probability of that result based on user picks.
Payouts are live at the time of writing and are subject to change. Tennis winner markets are available in 36 states.
Amanda Anisimova vs. Jessica Pegula Cincinnati Open Prediction – Thursday, August 20
Match Winner Payouts: Anisimova 2.08x | Pegula 1.69x
Tournament Round: Quarterfinals
2026 Record Entering the Cincinnati Open: Anisimova 17-10 | Pegula 40-11
Head-to-Head Record: Pegula leads 5-0
Scheduled Time: 1:00 p.m. ET
How to Watch: Tennis Channel
Following uneven results ever since her wrist injury in the spring, Amanda Anisimova entered the Cincinnati Open with many questions, but she’s now strung together three consecutive victories for the first time since February.
Over the last two rounds, she defeated a red-hot Alexandra Eala and Wimbledon champion Linda Noskova. Her straight-sets win over Noskova was particularly impressive, as the American didn’t even face a single break point.
Despite Anisimova’s rise in form, she’ll get a tough test against Jessica Pegula.
Pegula has already amassed an 8-2 record on hard courts this summer, which includes finishing runner-up in Washington earlier this month.
She’s produced strong results on hard courts all season, going 27-6 while reaching the semifinals at the Australian Open and winning a title in Dubai. Further, the 32-year-old is 11-4 vs. top-20 opponents on the surface this year.
Pegula has dominated the head-to-head against Anisimova, too, winning all five of their meetings, including two victories in 2026.
While Anisimova’s improved play is showing hints of the player who reached two major finals last season, Pegula’s consistency and dominance in this matchup probably can’t be overlooked.
Tennis Abstract’s Elo ratings rank Pegula as the fourth-best player on hard courts, while Anisimova is 18th. The result is a projected 72.5% win probability in favor of Pegula.
Make your Anisimova vs. Pegula Cincinnati Open prediction on PrizePicks now!
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Amanda Anisimova vs. Jessica Pegula Pick for the Cincinnati Open on Thursday
While Pegula is undefeated against Anisimova, their matches tend to be close, and their most recent meeting in Dubai this year went three sets. Overall, their matches have gone 20, 32, 24, 21, and 26 total games.
At this event, both players have been pushed to a deciding third set by top-20 opponents. Pegula needed 30 total games to get past Sorana Cirstea, while Anisimova went 28 games against Eala.
In Pegula's 10 matches against top-10 opponents this season, seven have gone three sets and/or featured a tiebreaker.
Despite going 8-2 in her hard-court matches this summer, Pegula has been broken at least twice in nine of them.
Anisimova vs. Pegula Pick – 22.5 Total Games
Make Your Cincinnati Open Predictions Today on PrizePicks
Amanda Anisimova and Jessica Pegula should give us an entertaining matchup between two of the best players on the WTA Tour. Which American advances to the Cincinnati Open semifinals?
Don’t wait until Thursday’s matches start — make your Cincinnati Open predictions on PrizePicks now.
Pick your players, predict More or Less on their stats like games won or aces, or make match winner predictions with Team Picks, available in 36 states!
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