%201.jpg)
Week 10 of the college football season features seven matchups between ranked teams, including a much-anticipated SEC battle between #5 Alabama and #14 LSU on Saturday, November 7. In Saturday’s Alabama-LSU game at 3:30 p.m. ET on ABC, the Tigers are favored at home, with a 1.4x payout to secure a win on PrizePicks.
Alabama snapped a two-game losing streak with a 31-20 victory over Texas A&M in Week 9 to improve to 6-2. As for LSU, it’s coming out of the team’s bye week on a two-game winning streak following a disappointing Week 6 defeat to Kentucky.
We'll break down our Alabama vs. LSU prediction and CFB picks for Saturday’s SEC showdown, including the spread, over/under, and top player picks on PrizePicks.
Make your Alabama vs. LSU prediction for Week 10 CFB on PrizePicks now!
{{cfb_offer_banner="/style-system/ui-components-playbook"}}
Alabama vs. LSU Prediction, Spread, Over/Under – Saturday, November 7
The LSU Tigers enter Saturday’s game as a 6.5-point home favorite against Alabama, returning a 1.4x payout on PrizePicks if they win outright.
Sitting at 6-2 overall and 4-1 in SEC, #5 Alabama is squarely in the College Football Playoff picture, but that may change with a loss here. Meanwhile, #14 LSU is on the outside looking in; a win over Kentucky would surely put them back into the driver's seat.
Here are the full payouts for the Alabama vs. LSU game on PrizePicks. PrizePicks data is live at the time of writing and is subject to change.
Make your Alabama vs. LSU pick on the spread or over/under on PrizePicks!
Stats used below are from Game on Paper, PFF, and Two Deep unless stated otherwise.
It’s been impressive to watch Alabama redshirt freshman QB Keelon Russell this season. Of the 65 college QBs with 250 or more dropbacks in 2026, Russell has the seventh-most yards per attempt (9.2) and the 13th-highest adjusted completion percentage (77.8%).
However, how will the inexperienced signal-caller handle playing in a hostile environment in Baton Rouge? Russell ranks 175th in college football with 9 turnover-worthy plays this year, per PFF, with 3 of those coming in his toughest road test yet vs. Tennessee, a 26-10 just three weeks ago.
If the Crimson Tide want to come away with a win, they’ll need Russell and the aerial attack to keep drives alive and match the Tigers’ explosive plays on offense.
With LSU QB Sam Leavitt leading the offense, the Tigers are beginning to find their identity: control the clock and pick their spots to generate game-changing plays. LSU ranks 20th out of 138 FBS schools in time of possession rate (54.0%), per Team Rankings.
In the same 65-QB sample from above, Leavitt has the 12th-most yards per attempt (8.5) and the sixth-highest adjusted completion percentage (79.5%). Interceptions were costly for Leavitt to begin the season, but he’s gone back-to-back starts without throwing the ball to the opposing team.
Before Saturday’s SEC clash begins, LSU is second-highest ranked favorite to win the SEC Championship (6.66x payout) on PrizePicks. Alabama is right behind them, with a 7.14x payout in the same market. This game will make a world of difference.
Make college football predictions on winners, futures and more on PrizePicks!
Alabama vs. LSU Prediction on the Spread – 11/7/26
Here are the key game stats and trends behind our Alabama vs. LSU prediction on the spread, set a 6.5 points for the Saturday, November 7 game in Baton Rouge, La.
- Although Alabama is in the 74th percentile in late-down success rate (49.5%), it is 91st out of 138 FBS schools in average third-down distance (7.3 yards).
- Meanwhile, LSU’s defense is in the 80th percentile in late-down success rate allowed (38.5%) and 4th in average third-down distance allowed (8.2 yards).
- The Crimson Tide have struggled to run the ball in recent weeks, and there’s a lot of pressure on Russell to deliver on the road against a Tigers defense that is in the 99th percentile in EPA/pass allowed (-0.24).
- LSU has taken care of business at home against SEC foes this year, defeating ranked Texas A&M and Mississippi State teams by a combined score of 66-6 at Tiger Stadium.
- Alabama has failed to cover the spread in three straight games, all against SEC opponents.
- In addition to the Tigers going 2-0 against the spread (ATS) in their last two games, they are also 2-1 ATS against ranked opponents this year.
- In comparison, the Crimson Tide are 1-3 ATS when facing ranked opponents.
- LSU last lost at home almost a year ago to the date vs. Alabama, 20-9, on Nov. 8, 2025.
Lock in your Alabama vs. LSU prediction on PrizePicks now!
{{cfb_offer_banner="/style-system/ui-components-playbook"}}
Alabama vs. LSU Picks for PrizePicks CFB Today – Saturday, November 7
Here are the top Alabama vs. LSU picks to target on Saturday, November 7, in a key SEC matchup. Today’s college football picks for PrizePicks include Jackson Harris and Rico Scott.
LSU WR Jackson Harris vs. LSU: 68.5 Receiving Yards
- Harris has tallied 85 or more receiving yards in three of his last five games.
- Across LSU’s first eight games, Harris leads the team in targets (53), yards per reception (17.6), and yards per route run (2.87).
- Alabama’s defense is susceptible to explosive pass plays, ranking 83rd out of 138 FBS schools in yards per dropback allowed (6.8).
- While the Crimson Tide are in the 73rd percentile in EPA/pass allowed (-0.04), they are in the 42nd percentile in passing success rate allowed (44.3%).
Pick Jackson Harris receiving yards + Bama-LSU spread on PrizePicks now!
Alabama WR Rico Scott vs. LSU: 3.5 Receptions
- Once again, Alabama needs to maintain drives to keep LSU’s offense off the field, which can lead to more quick, easy passes.
- Scott has at least 4 receptions in three of his last four games.
- Through the Crimson Tide’s first eight games, Scott has the most targets (45) in the offense.
- Russell has completed at least 19 passes in four of his last six starts, and Alabama is expected to play from behind, according to the spread, which could lead to more passing situations late in the game.
Pick Rico Scott receptions + Bama-LSU spread on PrizePicks now!
{{cfb_offer_banner="/style-system/ui-components-playbook"}}
Make Alabama vs. LSU Prediction on PrizePicks
#5 Alabama and #14 LSU both have two losses entering Week 10, so Saturday’s result holds a ton of weight in the College Football Playoff picture.
With the Tigers playing in front of their home crowd and having an extra week to prepare, they’re in a stellar spot to improve to 7-2, as seen by the 6.5-point spread.
Don’t wait until kickoff at 3:30 p.m. ET — make your Alabama vs. LSU picks on PrizePicks now and earn real money if you’re right.
Pick college football players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on college football game winners, spreads, and over/unders, now available in 36 states.
Stay locked in on Playbook for daily college football predictions, picks, and news all the way through the 2026 College Football Playoff.
Team Picks and Culture Picks are event contracts offered by Performance Predictions II, LLC d/b/a PrizePicks Predict, a CFTC-registered FCM and NFA Member. All event contract customers must be U.S. residents and 18+. Some event contracts may not be available in every state.Event contract trading carries significant risk and is not appropriate for everyone. No guarantee against loss is offered. Past results are not necessarily indicative of future results.Void where prohibited by law. Restrictions apply. For full terms of service see prizepicks.com/predict-regulatory. Team and Culture Pick Early Payouts subject to market liquidity. The content provided is for informational and educational purposes only and does not constitute investment advice, or a recommendation to trade any commodity interest.
