#23 Oregon vs. #12 Ohio State Prediction, Spread, NCAAF Picks Today – 11/7/26

Across Week 10’s college football lineup with seven top-25 matchups, the Big Ten has one ranked battle on deck for Saturday, November 7. The #23 Oregon Ducks (5-3) visit the #12 Ohio State Buckeyes (6-2) for a 3:30 p.m. ET kickoff on CBS, with Ohio State favored by 7.5 points on the spread, via PrizePicks.

During the preseason, both schools were expected to be among national championship contenders, but Oregon QB Dante Moore and Ohio State QB Julian Sayin have been out due to injuries. Without their starting QBs, combined with deflating play, the Ducks and Bucks have disappointed with only a few weeks remaining in the regular season.

Below, we’ll look at each team’s recent performance and more in our Oregon vs. Ohio State prediction, capped by picks for player projections on PrizePicks.

Make your Oregon vs. Ohio State picks on PrizePicks now! 

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#23 Oregon vs. #12 Ohio State Prediction, Spread, Over/Under for CFB Week 10 – Saturday, November 7

Ohio State is a 7.5-point favorite for the spread, paired with a 1.31x payout to win on PrizePicks — or a $131 payout on a $100 entry if you’re right.

Here are the full payouts for Oregon vs. Ohio State, including winner payouts, the spread, and over/under. PrizePicks data is live at the time of writing and is subject to change.

Make your Oregon vs. Ohio State prediction on the over/under on PrizePicks!

Following a scary head injury, Oregon has been without QB Dante Moore since September 26. He remains out on Saturday, paired with the absence of lead RB Jordon Davison (439 rushing yards). 

Ducks WR Jeremiah McClellan is currently probable and expected to play in his first game since Week 2. He produced 150 receiving yards in his only full outing vs. Boise State in Week 1. Oregon finally has a healthy receiving corps with McClellan joining WRs Dakorien Moore and Evan Stewart.

Since becoming the starting QB once again, QB Dylan Raiola hasn’t looked back since, producing 291.0 passing yards per game, 3 passing TDs, and 0 INTs in his last two. 

After hitting rock bottom in a 21-10 loss vs. Illinois on October 24, Oregon looks to follow up last week’s impressive 34-26 win over Northwestern, which is 20th nationally in adjusted EPA per play, via Game on Paper.

Unlike the Ducks, Ohio State had an absolute collapse in a 30-18 loss vs. USC as 6.5-point favorites last week. It was backup QB Luke Fahey’s first game as the starter since Julian Sayin went down from injury, but the offense still produced 464 yards.

Instead, it was 11 penalties and a poor red zone offense that crushed the Buckeyes. Plus, the defense — which allows only 15.5 PPG (92nd percentile) — had a season-worst showing by ceding 27 points in three quarters alongside multiple explosive plays.

OSU has lost twice before November for the first time since 2011. Last week’s loss was one of head coach Ryan Day’s worst losses during his tenure — joining the likes of 2024’s 13-10 loss as 19.5-point favorites vs. Michigan.

The absence of Buckeyes CB Jay Timmons was arguably more significant than no Sayin vs. USC. Timmons is back in the lineup on Saturday, but Sayin and RB Ja’Kobi Jackson are still out, while LT Ian Moore is questionable.

Oregon’s College Football Playoff hopes are likely over, and Ohio State’s playoff essentially begins now.

According to PrizePicks, Ohio State has a 1.85x payout to make the CFP, compared to 1.88x for missing the postseason. The Buckeyes remain in Big Ten championship contention, sporting the second-shortest payout to win the conference (3.12x). In short, OSU likely needs to win out to make the CFP.

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Oregon vs. Ohio State Prediction on Over/Under for CFB Week 10 – 11/7/26

As mentioned, Ohio State’s offense actually moved the ball well last week, featuring 464 total yards, 204 rushing yards, and 4.7 yards per carry. The Buckeyes ended up settling for four field goals due to red zone struggles, but Oregon allows an 84.62% red zone scoring rate (47th percentile), per TeamRankings.

The Ducks’ defense is vulnerable in multiple areas, such as allowing a 6.61 average third-down distance (26th percentile) and -0.02 EPA per rushing attempt (56th percentile). That implies OSU can stay on schedule, and that’s key with a true freshman QB in the red zone.

Pass protection for OSU often struggled vs. USC, allowing 13 pressures, per Pro Football Focus. But Oregon has a mediocre 15.9% havoc rate on defense (53rd percentile). That gets even more concerning with the Ducks’ 7.2% havoc rate in the front seven (ninth percentile), meaning U of O often has to blitz; that’s a recipe for disaster against Ohio State WR Jeremiah Smith.

On the flip side, Oregon’s passing attack is in a great place. Dylan Raiola just had his best performance as a Duck, providing 4 big-time throws. He had only 2 big-time throws combined in his previous five outings.

Turnovers could be the Ducks’ biggest concern, as Raiola still had 4 turnover-worthy plays in his past two. Oregon posts 1.9 turnovers per game (ninth percentile), and Ohio State forces 1.4 takeaways per contest (70th percentile).  

But there’s still reason to believe the Ducks can find some success thanks to a healthy, talented receiving corps. Oregon has a 1.64 pass explosiveness rating on offense (76th percentile), via Fourth and Short, and the Scarlet and Gray give up a 1.59 explosiveness rating (33rd percentile).

According to College Football Nerds’ game projection model, Ohio State is forecasted to win 33.2-16.0, and that’s a 49.2 combined total.

Lock in your Oregon vs. Ohio State prediction on PrizePicks before kickoff!

Oregon vs. Ohio State Picks, Player Stats for PrizePicks – 11/7/26

Today’s Oregon vs. Ohio State picks are headlined by Dakorien Moore and Isaiah West on PrizePicks.

Oregon WR Dakorien Moore vs. Ohio State: 58.5 Receiving Yards

• Dakorien Moore is Oregon’s big-play threat, with a team-high 13 targets on deep balls. The second-highest mark on the team is only 5 from Evan Stewart.
• As mentioned, Ohio State has an explosives problem in the secondary, and that included allowing 69- and 70-yard catches vs. USC. 
• Moore posts 13.3 yards per reception and has posted a catch above 20 yards in all eight appearances, including a 75-yard play last week.
• The sophomore wideout has surpassed this projection in three of his last four, averaging 77.8 receiving yards per game in the split.
• Furthermore, Ohio State CB Jay Timmons is arguably the Buckeyes’ best cover corner and primarily plays nickel. Evan Stewart has a 73.9% slot snap rate, and Jeremiah McClellan is playing his first game since Week 2. Moore could be the alpha dog on Saturday.  

Add Dakorien Moore to your PrizePicks lineup now!

Ohio State RB Isaiah West vs. Oregon: 37.5 Rush Yards 

• The Buckeyes had 43 carries compared to 38 passing attempts last week (53.1% rush play rate). 
• Despite a negative game script with a 27-9 deficit entering the fourth quarter, that rush play rate vs. USC stayed on par with OSU’s season-long 53.81% mark (59th percentile). 
• Unlike past Ryan Day offenses, playing with tempo and aggressive concepts, Ohio State’s units have slowly gotten more and more conservative over the years. The offense’s scheme to utilize multiple tight end sets with 27.4 seconds per play (69th percentile for slowest paces) likely won’t change overnight, and that means running the football.
• Isaiah West comes off season highs with 13 carries and 65 rushing yards (5.0 YPC), and he posted 6 attempts for 45 yards (7.5 YPC) vs. Indiana two weeks ago. 
• Oregon allows 4.0 YPC (58th percentile), 152.6 rushing yards per game (49th percentile), and generate a low 18.6% stuff rate (42nd percentile). 

Pick Isaiah West + Ohio State to win on PrizePicks!

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Make Oregon vs. Ohio State Picks on PrizePicks

Oregon comes off one of its best performances of the season, while Ohio State just suffered one of its worst losses in years. With the Buckeyes’ CFP hopes on the line, this could turn into a back-and-forth duel due to each offense holding some advantages.

Don’t wait until kickoff — make your Oregon vs. Ohio State picks on PrizePicks now. Just pick your players, predict More or Less on their stats, and cash in on your predictions if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders — now available in 36 states!

Keep it here with the Playbook for continued CFB picks, predictions, futures, and more all the way through the 2026 College Football Playoff.