Yankees vs. Red Sox is set for first pitch at 6:10 p.m. ET on Thursday, April 23, with the Yankees returning a 1.61x payout if they win, via PrizePicks.
The Yankees will go for the sweep with SP Cam Schlittler (2-1, 1.95 ERA) on the mound. The Red Sox, meanwhile, try to salvage a game with youngster SP Payton Tolle, who will be making his first appearance in the majors for the season.
Below, we’ll break down our Yankees vs. Red Sox prediction and picks for Thursday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.
Make your picks for Yankees vs. Red Sox on PrizePicks now.
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Yankees vs. Red Sox Prediction, Winner Payout, Over/Under – Thursday, April 23
The Red Sox have scored just 1 run over the first two games of this series. They've scored the fifth-fewest runs in baseball (90) on the year and have the third-lowest OPS (.643).
The Yankees continue to receive excellent production from their starting rotation. In the first two games of this series, SPs Luis Gil and Max Fried combined to throw 14.1 scoreless innings while allowing just 5 hits.
Four of the five members of the Yankees' starting rotation have an ERA of 3.18 or lower. That includes Schlittler, who has a 1.95 ERA that's backed by a 2.27 xERA.
Yankees vs. Red Sox Winner Payout, Over/Under – Thursday, April 23
The Yankees enter Thursday’s game as a road favorite against the Red Sox, returning a 1.61x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Yankees vs. Red Sox game on PrizePicks.
- Spread: New York Yankees -1.5 (2x payout)
- Over/Under: 8.5 runs (1.92x payout Over)
- Game Winner Payout: Yankees 1.61x | Red Sox 2.17x
Play the Yankees vs. Red Sox winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live as of writing and is subject to change.
Yankees vs. Red Sox Prediction on Winner – 4/23/26
Here are the key game stats and trends behind our Yankees vs. Red Sox prediction on the winner for Thursday, April 23.
Lock in your Yankees vs. Red Sox prediction on PrizePicks before the line moves.
- The Yankees have won five straight games to improve to 15-9 for the season, which is the best record in the American League.
- Schlitter dominated the Red Sox in the MLB playoffs last year, recording 12 strikeouts over 8 scoreless innings. In that outing, he surrendered just 5 hits and didn't walk a single batter.
- The emerging righty has made 19 career starts in the majors, giving up 3 or fewer runs in 17 of them.
- Tolle has spent this year at Triple-A, but he logged 16.1 innings for the Red Sox last season to the tune of a 6.06 ERA and 4.68 xERA.
- A main reason the young lefty struggled with the Red Sox was his 1.59 WHIP.
Yankees vs. Red Sox Player Picks, Stats for PrizePicks: 4/23/26
Here are top Yankees vs. Red Sox picks to target on PrizePicks for Thursday, April 23. Today's MLB picks for PrizePicks include OF Aaron Judge and SP Cam Schlittler.
Yankees OF Aaron Judge vs. Red Sox Projection: 7.5 Hitter Fantasy Score
- Judge went 1-for-2 with 2 walks, 2 runs scored, and a stolen base in Wednesday’s 4-1 victory. The slugger is 2-for-5 in the series with 4 walks and 3 runs scored.
- Judge has a .345 ISO, putting him on pace to have a mark at least that high for the fifth straight season, according to FanGraphs.
- Although he's known for his power, Judge already has 5 stolen bases through 24 games. He's on track to steal at least 10 bases for the fourth time over the last five seasons.
- The reigning AL MVP has a career .436 wOBA and a .345 ISO against left-handed pitchers.
Add Aaron Judge to your PrizePicks Lineup now.
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Yankees SP Cam Schlittler vs. Red Sox Projection: 6.5 Strikeouts
- Schlittler recorded at least 7 strikeouts in four of his five starts. The one time he didn’t, he just missed with 6 strikeouts against the Kansas City Royals in his last outing.
- After posting a 27.6% strikeout rate last season, the 25-year-old has a 34.3% K-rate this year.
- Per Baseball Savant, Schlittler has a 46.7% whiff rate on his curveball and a 42.7% whiff rate on his four-seamer.
- The powerful hurler has an overall whiff rate of 32.4%. In 2025, that mark was 26.1%.
Add Cam Schlittler to your PrizePicks Lineup now.
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The Yankees have a starting pitching advantage as they go for the sweep over the Red Sox on Thursday. Schlittler may be in position to keep racking up strikeouts, while Tolle could have his hands full with Judge. Can Boston pull off an upset?
Don’t wait until the first pitch — make your Yankees vs. Red Sox picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.
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