Yankees vs. Red Sox is set for first pitch at 6:45 p.m. ET on Wednesday, April 22, with the Yankees returning a 1.66x payout if they win the clash on MLB Network and Prime Video, via PrizePicks.
We have a great starting pitching matchup of Yankees SP Max Fried (2-1, 2.97 ERA) taking on Red Sox SP Ranger Suarez (1-1, 3.22 ERA). That could lead to another low-scoring affair after the Yankees won Tuesday’s series opener 4-0.
Below, we’ll break down our Yankees vs. Red Sox prediction and picks for Wednesday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.
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Yankees vs. Red Sox Prediction, Winner Payout, Over/Under – Wednesday, April 22
After being held scoreless Tuesday, the Red Sox now rank 26th in baseball in runs with 89. They have just 13 home runs, tied with the San Francisco Giants for the fewest in the majors. Only the New York Mets (.617) have a worse OPS than Boston (.652).
Last season, the Yankees had the highest OPS in baseball (.787). They haven’t been as productive this year but still rank sixth with a .737 mark. They also have 33 homers, with OF Aaron Judge (9) and 1B Ben Rice (8) combining to hit more than the entire Red Sox team.
Yankees vs. Red Sox Winner Payout, Over/Under – Wednesday, April 22
The Yankees enter Wednesday’s game as a road favorite against the Red Sox, returning a 1.66x payout if they win outright, via PrizePicks Team Picks.
Here are the full payouts for the Yankees vs. Red Sox game on PrizePicks.
- Spread: New York Yankees -1.5
- Over/Under: 7.5
- Game Winner Payout: Yankees 1.66x | Red Sox 2.12x
Play the Yankees vs. Red Sox winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!
Team Picks data is live as of writing and is subject to change.
Yankees vs. Red Sox Prediction on Winner – Wednesday, April 22
Here are the key game stats and trends behind our Yankees vs. Red Sox prediction on the winner for Wednesday, April 22.
Lock in your Yankees vs. Red Sox prediction on PrizePicks before the line moves.
- The Yankees have a shaky bullpen, but that concern is lessened when Fried takes the mound. He's logged at least 6.1 innings in four of his five starts this year.
- New York has won four straight games to gain the lead in the American League East. The Red Sox are in last place at 9-14.
- The Yankees have a +32 run differential, the fourth-highest mark in baseball.
- The Red Sox already have difficulties hitting home runs, and facing Fried may not help matters one bit. The star lefty has allowed just 0.7 HR/9 for his career.
- Per FanGraphs, the Red Sox rank 19th in barrel rate (7.4%), which could be a key factor in their lack of home runs. The Yankees are first at 12.6%.
Yankees vs. Red Sox Player Picks, Stats for PrizePicks: 4/22/26
Here are top Yankees vs. Red Sox picks to target on PrizePicks for Wednesday, April 22. Today's MLB picks for PrizePicks include OF Aaron Judge and SP Max Fried.
Yankees OF Aaron Judge vs. Red Sox Projection: 7.5 Hitter Fantasy Score
- Judge went 1-for-3 with 2 walks and 1 run scored in the series opener Tuesday. That extended his streak to 11 straight games of getting on base at least once.
- The three-time MVP is only batting .235 but may be unlucky given his .234 BABIP. His career mark is .346.
- Judge is still hitting the ball hard, recording a 26.3% barrel rate and a 50.9% hard-hit rate.
- The slugger has dominated left-handed pitching, notching a career .435 wOBA and .346 ISO against them.
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Yankees SP Max Fried vs. Red Sox Projection: 5 Strikeouts
- Despite pitching deep into his starts, Fried has recorded at least 5 strikeouts in just two of his five games.
- The southpaw doesn’t miss a ton of bats, posting a 23.7% strikeout rate for his career.
- Fried is successful even with his modest strikeout production because he limits hard contact. In 2026, he's given up a 1.1% barrel rate and a 29.8% hard-hit rate.
- As bad as the Red Sox have been, they aren’t swinging and missing a ton. Their 23.4% strikeout rate is just the 12th-highest in the majors.
Add Max Fried to your PrizePicks Lineup now.
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Two southpaws face off Wednesday, with Fried and Suarez battling in Boston. As good as Fried has been, he thrives at inducing weak contact. Judge, known for making loud contact, will aim to stay hot and continue his career success against lefties.
Don’t wait until the first pitch — make your Yankees vs. Red Sox picks on PrizePicks now and earn real money if you’re right.
Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.
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