Yankees vs. Orioles Prediction, MLB Picks for Wednesday, August 19

Yankees vs. Orioles is set for first pitch at 6:35 p.m. ET on Wednesday, August 19, with the Yankees favored and returning a 1.75x payout if they win, via PrizePicks.

With Yankees SP Max Fried (elbow) on the injured list again, SP Will Warren (8-6, 4.42 ERA) will remain in the starting rotation and take the hill Wednesday. The Orioles will deploy SP Chris Bassitt (4-4, 5.11 ERA), who will make his second start since coming off the IL.

Below, we’ll break down our Yankees vs. Orioles prediction and picks for Wednesday’s MLB game, including the game winner, over/under, and key player picks for PrizePicks.

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Yankees vs. Orioles Prediction, Winner Payout, Over/Under – Wednesday, August 19

The Yankees have fallen to 19th in runs scored because of injuries to some of their key hitters. However, their pitching staff has kept them in the playoff hunt. Per FanGraphs, they have the third-best xERA (3.63) and allow only 0.99 HR/9 while ranking fourth in WHIP (1.18).

Pitching is not a strength for the Orioles. Their xERA checks in at 4.13, and their 1.35 WHIP is 22nd in baseball. Their staff does not miss a lot of bats, posting a 20.8% strikeout rate. The Yankees are fifth in baseball with their 24.2% strikeout rate.

Yankees vs. Orioles Winner Payout, Over/Under – Wednesday, August 19

The Yankees enter Wednesday’s game as a road favorite against the Orioles, returning a 1.75x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the Yankees vs. Orioles game on PrizePicks Team Picks — where you can make real-money predictions on every MLB game!

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Team Picks data is live as of writing and is subject to change.

Yankees vs. Orioles Prediction on Winner – Wednesday, August 19

Here are the key game stats and trends behind our Yankees vs. Orioles prediction on the winner for Wednesday, August 19.

• The Yankees have a better record on the road (39-28) than they do at home (31-27).
• Baltimore is 2-6 against New York this season.
• Despite their offensive limitations, the Yankees still have a +87 run differential. The Orioles have a -29 run differential.
• After recording a 1.46 WHIP and a 1.33 WHIP the last two seasons, Bassitt continues to struggle in that department with a 1.62 WHIP this year.
• New York also has a significant advantage at the end of games. Their bullpen has a 3.04 ERA and a 1.20 WHIP, compared to Baltimore’s bullpen having respective marks of 4.13 ERA and 1.29.

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Yankees vs. Orioles Picks, Player Stats for PrizePicks: 8/19/26

Here are top Yankees vs. Orioles picks to target on Wednesday, August 19. Today's MLB picks for PrizePicks include SP Will Warren and SS George Lombard Jr.

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Yankees SP Will Warren vs. Orioles: 5 Strikeouts

• Despite a few rough performances lately, Warren still finished with at least 5 strikeouts in three of his last four starts.
• The Yankees might need added length from their right-handed hurler after SP Carlos Rodon only lasted 4 innings in his return from the IL on Tuesday. That forced them to use five relievers in their 3-1 victory.
• The Orioles have the fourth-highest strikeout rate (24.3%) in the sport entering Wednesday's play.
• Warren has faced Baltimore two times this season. He pitched at least 5.2 innings in both outings, finishing with 9 and 6 strikeouts.

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Yankees SS George Lombard Jr. vs. Orioles: 3.5 Hitter Fantasy Score

• After recording a .971 OPS over 20 games at Double-A this year, Lombard posted a .845 OPS across 56 games at Triple-A.
• Since being called up to the majors, the promising young shortstop is 12-for-41 (.293) with 2 home runs and a .370 OBP over 12 games.
• Lombard has shown a good eye at the plate, posting a 16.8% walk rate and a 21.2% strikeout rate across various levels in the minors this year. With the Yankees, he has respective figures of 10.9% and 21.7%.
• With Bassitt allowing so many base runners, he has a 5.11 ERA that's backed by a 5.08 xERA. He isn’t fooling many hitters, leaving him with just a 14.0% strikeout rate.

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The Yankees will try to win the second game of this series against the Orioles behind the strength of their pitching staff. Warren could rack up strikeouts in this favorable matchup, while Lombard aims to exploit Bassitt’s inability to keep hitters off base.

Don’t wait until the first pitch — make your Yankees vs. Orioles picks on PrizePicks now and earn real money if you’re right.

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