On an eight-game slate across MLB action for Friday, March 27, the New York Yankees (1-0) will take on the San Francisco Giants (0-1) to get things started at 4:35 p.m. ET on ESPN.
The Yankees and Giants got the 2026 MLB season underway on Wednesday, with New York securing an impressive 7-0 victory on Opening Night.
Below, we’ll break down our Yankees vs. Giants prediction and picks for Friday’s matchup. Make your MLB picks on PrizePicks and earn real money if you’re right, including on game winners, spreads, and totals!
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Yankees vs. Giants Prediction, Spread, Over/Under
For the second game of the series between New York and San Francisco, SP Cam Schlittler (3.77 xFIP in 2025) is expected to be on the bump against veteran SP Robbie Ray (4.29 xFIP) on Friday.
Despite the Yankees generating plenty of offense during Wednesday’s win, RF Aaron Judge had 4 strikeouts across 5 plate appearances. Judge is still arguably the best hitter in baseball, however, and his bat can get hot at any moment.
On the other hand, the Giants’ lineup struggled to find a rhythm against SP Max Fried and New York’s bullpen, totaling just 3 hits and 6 strikeouts. San Francisco is hoping to perform better at the plate against Schlittler, who is entering his first full season as a starter in the majors.
Yankees vs. Giants Spread, Over/Under
The Giants enter Friday’s game as home underdogs, returning a 2.08x payout on PrizePicks Team Picks if they win outright.
The Yankees are road favorites with a 1.69x payout if they win, via PrizePicks Team Picks, where you can earn money with your picks in 35 states.
- Spread: Yankees -1.5 (2.22x payout)
- Over/Under: 7.5 Runs (1.72x payout on over)
- Game Winner Payout: Giants 2.08x | Yankees 1.69x
Team Picks data is live at the time of writing and is subject to change.
Yankees vs. Giants Prediction to Win – 3/27/26
Here are the key stats to know before locking in your Yankees vs. Giants prediction on the winner for Friday, March 27, on PrizePicks.
- The Giants recorded a 9-10 record as a home underdog in 2025.
- As a road favorite last season, the Yankees went 40-30.
- According to FanGraphs, New York led the league in wRC+ (121), wOBA (.339), and ISO (.201) against left-handed pitching a season ago.
- San Francisco tallied the 12th-worst wRC+ (99), eighth-worst wOBA (.304), and 10th-worst ISO (.146) at home.
- Although Robbie Ray was in the 64th percentile in xERA (3.71), he was also in the 20th percentile in walk rate (9.7%), 26th percentile in barrel rate (9.6%), and 16th percentile in hard-hit rate (44.7%) last year (per Baseball Savant).
- Despite Oracle Park being a pitcher-friendly venue, Ray produced a 4.38 xFIP and 1.26 WHIP at home, compared to a 4.20 xFIP and 1.16 WHIP on the road.
Yankees vs. Giants Picks for PrizePicks Today: 3/27/26
Here are the top Yankees vs. Giants picks to target for Friday, March 27. Today’s MLB picks for PrizePicks are headlined by Yankees RF Aaron Judge and Giants DH Rafael Devers.
Yankees RF Aaron Judge vs. Giants Projection: 7.5 Hitter Fantasy Score
- Against southpaws last year, Aaron Judge accrued an elite 225 wRC+, .493 wOBA, and .447 ISO.
- Judge has registered at least a 204 wRC+ and .458 wOBA in three of his last four seasons, per FanGraphs.
- Robbie Ray posted a .307 BABIP, 1.31 WHIP, and 1.06 HR/9 against righties at home last season. Versus lefties at home, Ray recorded a .246 BABIP, 1.14 WHIP, and 0.00 HR/9.
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Giants DH Rafael Devers vs. Yankees Projection: 1.5 Hits + Runs + RBIs
- As a left-handed slugger, Rafael Devers earned a 151 wRC+, .387 wOBA, and .256 ISO when facing a right-handed hurler in 2025.
- Devers owns at least a 126 wRC+ and .359 wOBA in each of his last five seasons.
- With 2B Luis Arraez (at least a .313 wOBA and .327 OBP in seven straight years) batting ahead of him, Devers may see more RBI opportunities.
Make Yankees vs. Giants Picks on PrizePicks
The Yankees can jump out to a 2-0 record with a win on Friday. Can the Giants bounce back following a lopsided shutout on MLB Opening Night?
You can make your Yankees vs. Giants picks on PrizePicks and PrizePicks Team Picks to earn real money. Just pick players, predict More or Less on their projected stats, and cash in if you’re correct. With Team Picks, make predictions on winners, spreads, and over/unders, now available in 35 states.
Stick around with the Playbook for continued MLB predictions, picks, and news throughout the 2026 season.
