White Sox vs. Yankees Prediction, MLB Picks for Wednesday, June 17

White Sox vs. Yankees is set for first pitch at 7:05 p.m. ET on Wednesday, June 17 on Prime Video, with the Yankees returning a 1.49x payout if they win, via PrizePicks.

This game will feature a battle of left-handed starters. The Yankees are rolling with Carlos Rodon (2-2, 3.19 ERA), who hasn't given up more than 3 runs in any of his six starts. The White Sox will counter with Anthony Kay (6-1, 4.34 ERA), who limited the Dodgers to 2 runs in his last outing.

Below, we’ll break down our White Sox vs. Yankees prediction and picks for Wednesday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.

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White Sox vs. Yankees Prediction, Winner Payout, Over/Under – Wednesday, June 17

These squads can certainly hit. According to FanGraphs, the Yankees have the second-highest wRC+ (115) in baseball, and the White Sox rank 11th at 104. Both sides are also missing a key slugger from their lineup.

The Yankees continue to play without OF Aaron Judge (ribs), while the White Sox are missing 1B Munetaka Murakami (hamstring).

A key difference is that the Yankees allow the fewest HR/9 (0.90) in baseball. The White Sox, meanwhile, are 18th (1.16) in that category. New York also has the second-best team WHIP (1.18) in the majors to Chicago's 1.33.

White Sox vs. Yankees Winner Payout, Over/Under – Wednesday, June 17

The Yankees enter Wednesday’s game as a home favorite against the White Sox, returning a 1.49x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the White Sox vs. Yankees game on PrizePicks Team Picks — where you can make real money predictions on every MLB game!

• Spread: New York Yankees -1.5 (2.04x payout)
• Over/Under: 8.5 runs (1.88x payout Over)
• Game Winner Payout: White Sox 2.43x | Yankees 1.49x  

Make your White Sox vs. Yankees prediction on spread or over/under on PrizePicks Team Picks — available in 35 states!

Team Picks data is live as of writing and is subject to change.

White Sox vs. Yankees Prediction on Winner – Wednesday, June 17

Here are the key game stats and trends behind our White Sox vs. Yankees prediction on the winner for Wednesday, June 17.

• The Yankees sit atop the AL East, aided by their 20-12 record at home.
• The White Sox also lead their division, largely thanks to their 24-12 home mark. However, they are only 14-21 on the road.
• The Yankees have the second-best run differential (+117) in the majors. The White Sox are five games above .500, albeit with a run differential of only +2.
• New York has the second-highest home OPS (.817) in baseball, as well as the highest OPS against left-handed pitchers (.794).
• The White Sox have a .718 OPS on the road compared to a .748 OPS at home.

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White Sox vs. Yankees Picks, Player Stats for PrizePicks: 6/17/26

Here are top White Sox vs. Yankees picks to target on Wednesday, June 17. Today's MLB picks for PrizePicks include Cody Bellinger and Paul Goldschmidt.

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Yankees OF Cody Bellinger vs. White Sox: 1.5 Hits + Runs + RBI

• Bellinger went 3-for-4 with 2 RBI and 2 runs scored in Tuesday’s 12-2 victory over the White Sox.
• The former Chicago Cub has shown an excellent eye at the plate, posting a 13.5% walk rate and a 12.2% strikeout rate.
• Bellinger thrives at Yankee Stadium, where he has a .479 wOBA and a .327 ISO.
• Although he won’t have the platoon advantage in this matchup, that hasn’t proven to be a disadvantage for the 30-year-old. Since the start of last season, he has a .400 wOBA and a .234 ISO against southpaws.

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Yankees 1B Paul Goldschmidt vs. White Sox: 5.5 Hitter Fantasy Score

• Goldschmidt also played well Tuesday, going 2-for-5 with 1 home run and 2 RBI.
• During his current eight-game hitting streak, the veteran first baseman is 14-for-34 (.412) with 3 home runs, 10 RBI, and 3 runs scored.
• Right-handed pitchers have limited Goldschmidt to a .668 OPS this year, but he has a 1.288 OPS against lefties.
• Kay’s 4.34 ERA doesn’t look terrible, yet his xERA is concerning at 5.65. He also allows too many base runners, posting a 1.42 WHIP.

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Following Tuesday’s lopsided victory, the Yankees will try to put another game in the win column with Rodon on the mound Wednesday. Looking to take advantage of the matchup against Kay will be Bellinger and Goldschmidt, who both started off the series on a high note Tuesday.

Don’t wait until the first pitch — make your White Sox vs. Yankees picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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