White Sox vs. Twins Prediction, MLB Picks for Monday, June 1

The Chicago White Sox (32-27) and Minnesota Twins (27-33) will face off in the opening game of their three-game series at Target Field on Monday, June 1, at 7:40 p.m. ET. 

This is the second series in two weeks between the AL Central teams, as the White Sox took three of four from the Twins at home last Monday through Thursday. 

Below, we’ll break down our White Sox vs. Twins prediction and picks for Monday’s MLB showdown, including the run line, over/under, and key player picks for PrizePicks.

Make your White Sox vs. Twins picks on PrizePicks for tonight's game.

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White Sox vs. Twins Prediction, Winner Payout, Over/Under – Monday, June 1

After meeting for four games in Chicago last week, the White Sox and Twins meet for the first of three games in Minnesota. Chicago took three of four last week at home, outscoring Minnesota 27-10. 

The White Sox followed up the series win over the Twins by sweeping the Detroit Tigers over the weekend to reach a season-high five games over .500. They now sit only one game behind the first-place Cleveland Guardians in the AL Central. 

Chicago sends SP David Sandlin (4.09 xFIP) to the mound for his second career start to face Twins SP Joe Ryan (3.45 xFIP). 

Sandlin’s first career start was last Wednesday, where he held this same Twins team to 1 run and 1 hit (a leadoff HR) over 6.0 IP to earn his first career win. After allowing a home run to the first batter of his MLB career, Sandlin retired the next 18 batters, striking out 4. He became the first White Sox pitcher to retire 18 in a row in his debut since 1920.

Ryan has been the best Twins pitcher this season, leading the team in xFIP (3.45), xERA (2.82), and BB/9 (1.96). His 2.1 WAR is fifth-best in the league. He will be making his 13th start of the season, with his previous one coming last Tuesday vs. the White Sox. He held Chicago to 2 runs over 7.2 IP, with 9 Ks and 0 BBs in the only game the Twins won in that series. 

White Sox vs. Twins Winner Payout, Over/Under – Monday, June 1

The Twins enter Monday’s game as favorites, returning a 1.58x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the White Sox vs. Twins game on PrizePicks.

• Spread: Minnesota Twins -1.5 (2.27x payout)
• Over/Under: 7.5 (1.75x payout on Over)
• Game Winner Payout: White Sox 2.27x | Twins 1.58x

Make your White Sox vs. Twins prediction on the winner or over/under on PrizePicks Team Picks to earn real money — available in 35 states!

Team Picks data is live at the time of writing and is subject to change.

White Sox vs. Twins Prediction on Over/Under – 6/1/26

Here are the key stats and trends behind our White Sox vs. Twins prediction for the run total on Monday, June 1.

Lock in your White Sox vs. Twins prediction on PrizePicks before the first pitch.

• The White Sox and Twins are two of the top five teams for the over this season.
• Chicago has played 34 overs to 23 unders (with two pushes) this season, the fifth-most overs in baseball.
• The Twins have played an even higher percentage of overs (61.8%), with 34 overs to 21 unders (five pushes). 
• When the two teams played last week, two of the games went over, one went under, and one pushed at 8 runs. 
• Chicago is ninth in the league (fourth in the AL) with 105 wRC+ and second in the AL in wOBA at .325, per FanGraphs.
• On the flip side, the White Sox pitching staff is 24th in the majors with a 4.28 xFIP and is starting a pitcher making his second career start. 
• The Twins are in the middle of the pack in both wRC+ (16th with 98) and wOBA (15th at .315)
• Minnesota is 27th in the majors in xFIP at 4.50 and 22nd in BABIP at .291.

White Sox vs. Twins Player Picks, Stats for PrizePicks: 6/1/26

Here are top White Sox vs. Twins picks to target on PrizePicks for Monday, June 1. Today’s MLB picks for PrizePicks include Colson Montgomery and Byron Buxton

White Sox SS Colson Montgomery vs. Twins: 4.5 Hitter Fantasy Score

• White Sox infielder Colson Montgomery has hits in five of the last six games with 2+ hits in four contests. 
• Montgomery has homers in his last two games, doubles in three of the last six games, and drove in 4 runs in this split. 
• The Huntingburg, Indiana product’s 2.4 WAR is 10th in the majors, while his .263 ISO average is 11th. 
• In last week’s four-game series vs. the Twins, Montgomery was 6 of 16 (.375), with 2 doubles, 2 runs, and 2 RBIs. 

Add Colson Montgomery to your PrizePicks Lineup now.

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Twins OF Byron Buxton vs. White Sox: 6.5 Hitter Fantasy Score

• Twins OF Byron Buxton has hits in 10 of the last 15 games, batting .300 with a .353 BABIP.  
• During the same 15-game stretch, Buxton has 6 HR, 10 RBIs, and 14 runs scored with 5 doubles and 2 SBs.
• The former No. 2 overall pick is fifth in the majors with a .303 ISO, fourth in slugging (.563), and 27th in wRC+ (142)
• In last week’s four-game series vs. the White Sox, Buxton was 3 of 13 (.231), with 3 BB, 1 HR, and 1 RBI.  

Add Byron Buxton to your PrizePicks Lineup now.

Make White Sox vs. Twins Picks on PrizePicks

Will the White Sox continue to surprise and stay within a game of the Guardians in the AL Central? Or will the Twins end a five-game losing skid and earn the win at home?

Don’t wait until lock — make your White Sox vs. Twins picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

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