White Sox vs. Guardians Prediction, MLB Picks for ALDS Game 2 – Monday, October 5

The Cleveland Guardians will host the Chicago White Sox in ALDS Game 2 on Monday, October 5 at 5 p.m. ET on TBS and truTV.

After sweeping the Houston Astros in the AL Wild Cardound, the White Sox got off to a strong start in Game 1 of the ALDS. Chicago topped Cleveland 3-0, led by a 2-run home run from 1B Munetaka Murakami. 

Below, we'll break down our White Sox vs. Guardians prediction and picks for Monday's ALDS Game 2, including the winner, over/under, and key player picks for PrizePicks.

Make your White Sox vs. Guardians picks on PrizePicks now.

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White Sox vs. Guardians Prediction, Winner Payout, Over/Under for ALDS Game 2 – Monday, October 5

The White Sox beat the Guardians in seven of 13 regular-season matchups before the ALDS got underway. The Guardians did come away victorious in two of the final three meetings in mid-September, which took place at Progressive Field. 

In Saturday’s Game 1, Murakami got the scoring started in the fourth inning after 3B Miguel Vargas singled to lead off the frame. SS Colson Montgomery added an RBI double in the seventh inning to give the White Sox some added insurance.

Prior to the ALDS, the White Sox racked up 13 runs in two games against the Astros. Chicago SP Anthony Kay, who will start Game 2 of the ALDS, earned the win in the series-clinching Game 2 against the Astros by tossing 0.2 scoreless innings without surrendering a hit.

Kay posted a 10-9 record with a 4.44 ERA and 129 strikeouts prior to the playoffs.

In the regular season, the White Sox ranked fifth in runs (776), home runs (211), and RBIs (740). According to Baseball Savant, Chicago sat eighth in hard-hit rate (40.1%), eighth in barrel rate (8.4%), and 13th in exit velocity (88.9 mph).

Meanwhile, the Guardians received a bye in the Wild Card after winning the AL Central by just a game over the White Sox with an 85-77 record. 

Cleveland doesn’t have the most lethal lineup in baseball. In fact, the Guardians ranked 24th in runs (678) and 27th in home runs (162) during the regular season while also posting the second-lowest barrel rate (5.8%), third-lowest hard-hit rate (35.0%), and 22nd-ranked xBA (.240).

Game 2 starting pitcher Gavin Williams led the Guardians in wins (14) and strikeouts (248) during the regular season. His 248 strikeouts were second in the majors behind only Milwaukee Brewers SP Jacob Misiorowski (252) after tallying a 33.2% strikeout rate (97th percentile). 

White Sox vs. Guardians Winner Payout, Over/Under for ALDS Game 2 – Monday, October 5

The Guardians enter Monday’s game as a home favorite against the White Sox, returning a 1.58x payout if they win outright, via PrizePicks.

Here are the full payouts for the White Sox vs. Guardians game on PrizePicks.

Play the White Sox vs. Guardians winner or over/under on PrizePicks Team Picks.

Team Picks data is live at the time of writing and is subject to change.

White Sox vs. Guardians Prediction on Over/Under for ALDS Game 2 – 10/5/26

Here are the key game stats and trends behind our White Sox vs. Guardians prediction on the over/under for Monday’s ALDS Game 2 matchup.

Lock in your White Sox vs. Guardians prediction on PrizePicks now.

• The over has cleared in six of the last eight matchups between these two AL Central rivals.
• In Kay’s final seven regular-season starts, the over carried a 6-1 record in those outings. Additionally, the two teams cleared the over of 8.5 runs in a 6-3 Guardians’ win on September 16.
• Kay has recorded a 5.05 xERA, ranking in just the 12th percentile. The veteran SP has also registered an 18.1% strikeout rate (20th percentile).
• Meanwhile, Williams pitches to a high amount of contact, surrendering a 46.6% hard-hit rate (first percentile).
• The White Sox have posted an impressive wRC+ of 104 throughout (fifth in the majors) on the year and averaged 5.3 runs per game in three contests this postseason.

White Sox vs. Guardians Picks, Player Stats for ALDS Game 2 on PrizePicks: Monday, October 5

Here are top White Sox vs. Guardians picks to target in Monday’s ALDS Game 2. Today’s MLB picks for PrizePicks include 1B Munetaka Murakami and 3B Jose Ramirez.

White Sox 1B Munetaka Murakami vs. Guardians: 0.5 Total Bases

• Murakami is hitting .280 (7-for-25) with 3 home runs, 6 RBIs, and 6 runs in his last six games.
• The White Sox slugger has recorded a 20.5% barrel rate, ranking in the 100th percentile.
• Murakami has registered a staggering 56.8% hard-hit rate (99th percentile) overall.
• The Chicago infielder blasted 28 of his 35 home runs against right-handed pitching, including slugging a solo home run off Williams on August 8.

Add Munetaka Murakami + White Sox to win to your PrizePicks lineup now.

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Guardians 3B Jose Ramirez vs. White Sox: 1.5 Hits + Runs + RBIs

• Ramirez is hitting .293 (12-for-41) with a home run, 4 RBIs, and 6 runs in his last 10 contests.
• The Guardians’ star at the hot corner has tallied a .277 xBA, which lands in the 77th percentile.
• Ramirez has registered at least a pair of combined hits, runs, and RBIs in six of his last 10 games.
• The seven-time All-Star owns a .287/.366/.469 slash line against left-handed pitching in 2026.

Add Jose Ramirez + Guardians to cover the spread to your PrizePicks lineup now.

Make White Sox vs. Guardians Picks on PrizePicks

The White Sox came away with a convincing win against the Guardians in what turned out to be a low-scoring affair in Game 1 of the ALDS. Will both teams’ bats be more active in Game 2 on Monday night? 

Don’t wait until lock — make your White Sox vs. Guardians picks on PrizePicks now and earn real money if you’re right.

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