White Sox vs. Astros Prediction, MLB Picks for Thursday, September 3

The White Sox vs. Astros is set for first pitch at 2:10 p.m. ET on Thursday, September 3, with the Astros having a 1.58x payout if they win, via PrizePicks Team Picks.

The White Sox will close out this four-game series with SP Luis Castillo (4-10, 5.31 ERA) on the mound. The Astros will try to build on Wednesday’s 2-0 victory with SP Hunter Brown (4-3, 3.33 ERA) toeing the rubber.

Below, we’ll break down our White Sox vs. Astros prediction and picks for Thursday’s MLB game, including game winner, over/under, and key player picks for PrizePicks.

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White Sox vs. Astros Prediction, Winner Payout, Over/Under – Thursday, September 3

Despite the White Sox and Astros leading their respective divisions, pitching has been a problem for both teams. According to FanGraphs, the White Sox rank 20th with their 4.27 xERA. The Astros have been even worse, posting a 4.32 xERA. Chicago has a 1.31 WHIP, while Houston has a 1.36 WHIP.

Houston’s pitching staff has been superior in strikeouts, carrying a 22.8% strikeout rate (10th). Chicago's 21.9% strikeout rate (tied for 16th) likely won’t be bolstered by Castillo, who only has a 19.4% strikeout rate this year.

White Sox vs. Astros Winner Payout, Over/Under – Thursday, September 3

The Astros enter Thursday’s game as a home favorite against the White Sox, returning a 1.58x payout if they win outright, via PrizePicks Team Picks.

Here are the full payouts for the White Sox vs. Astros game on PrizePicks Team Picks—where you can make real money predictions on every MLB game!

Make your White Sox vs. Astros prediction on the spread or over/under on PrizePicks Team Picks—available in 36 states!

Team Picks data is live as of writing and is subject to change.

White Sox vs. Astros Prediction on Winner – Thursday, September 3

Here are the key game stats and trends behind our White Sox vs. Astros prediction on the winner for Thursday, September 3.

• After losing two of the first three games of this series, the White Sox are only 32-39 on the road. At home, that jumps to 41-27.
• Chicago is 2-3 in games that Castillo has started since being acquired from the Mariners. He logged fewer than 5.0 innings in four of those outings.
• The White Sox have a 110 wRC+ at home but just a 98 wRC+ on the road.
• Right-handed pitchers have limited the White Sox to a .719 OPS, compared to their .739 OPS against lefties.
• Brown has allowed 2 or fewer runs in five of his last seven starts. That includes pitching 7.0 shutout innings against the White Sox in Chicago on July 25.

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White Sox vs. Astros Picks, Player Stats for PrizePicks: 9/3/26

Here are top White Sox vs. Astros picks to target on PrizePicks for Thursday, September 3. Today's MLB picks for PrizePicks include Luis Castillo and Yordan Alvarez.

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White Sox SP Luis Castillo vs. Astros: 2.5 Earned Runs Allowed

• Castillo allowed at least 3 earned runs in seven of his last eight starts.
• The former Mariner is having the worst season of his career, posting a 5.31 ERA that is backed by a 5.00 xERA.
• Allowing 1.7 HR/9 has played a significant role in Castillo’s struggles, and his bloated 1.44 WHIP only adds to the worry.
• The veteran righty has given up a 9.6% barrel rate that is on pace to finish as the second-highest mark of his career.

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Astros DH Yordan Alvarez vs. White Sox: 6.5 Hitter Fantasy Score

• Across his last 14 games, Alvarez is 14 for 45 (.311) with a .448 OBP. He posted almost as many walks (10) as strikeouts (11) during that span.
• The veteran slugger has already reached at least 30 home runs and 90 RBIs in a season for the fourth time in his career.
• Alvarez is a rare power hitter who doesn’t strike out much. He has a 17.4% strikeout rate to go along with his .287 ISO this season.
• Of the 23 home runs that Castillo has allowed, 16 launched off the bat of a left-handed hitter.

Add Yordan Alvarez to your PrizePicks lineup now!

Make White Sox vs. Astros Picks on PrizePicks

The Astros may have a starting pitching advantage Thursday as they try to win their four-game series against the White Sox.

Castillo’s inability to limit base runners and propensity for giving up home runs could result in another ugly stat line. Alvarez, who brings a ton of power to the plate, is in a favorable position to exploit Castillo.

Don’t wait until the first pitch—make your White Sox vs. Astros picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 36 states.

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