West Virginia vs. #25 Virginia Prediction, Spread, NCAAF Picks – Saturday, September 19

ACC and Big 12 schools will do battle on the gridiron when #25 Virginia hosts West Virginia in the Duke’s Mayo Classic on Saturday, September 19, at 7:30 p.m. ET on the ACC Network. Virginia is a 10.5-point home favorite and returns a 1.23x payout with a win, via PrizePicks.

Virginia has outscored its opponents 93-11 en route to a 2-0 start, including a 34-8 win over NC State in its season opener. Meanwhile, West Virginia is also 2-0 out of the gate with wins against Coastal Carolina and UT Martin.

Below, we’ll break down a West Virginia vs. Virginia prediction and picks for Saturday night's game, including the spread, over/under, and player projections for PrizePicks.

Make your West Virginia vs. Virginia picks on PrizePicks now! 

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West Virginia vs. #25 Virginia Prediction, Spread, Over/Under – Saturday, September 19

Virginia had an impressive season in 2025, finishing 11-3 and appearing in the ACC Championship Game for the first time since 2019. The Cinderella story fell just short, however, as Virginia lost to Duke in overtime of the ACC title game.

Virginia began 2026 with a statement victory against NC State. In that contest, the Cavaliers held the Wolfpack to just 168 yards of total offense and forced 2 turnovers. QB Beau Pribula completed 9 of 11 passes for 155 yards and 2 TDs and rushed for 110 yards.

Pribula has always been a threat to run but has excelled at throwing in two games. In fact, Pro Football Focus made him the highest-graded QB in Week 0 with a 90.0 rating.

The Cavaliers’ defense has been dominant, too, surrendering just 195.5 total yards per game (first in the ACC) and 130.0 passing yards per contest (second).

West Virginia tried to recapture its glory days of the early 2000s when the program hired head coach Rich Rodriguez before the 2025 season. In his first season in Morgantown since 2007, he led the Mountaineers to just a 4-8 record, although it did include a high point of a 45-35 win against #22 Houston in early November.

The Mountaineers are led by former Oklahoma QB Michael Hawkins Jr., who is getting his first chance as a full-time QB at the collegiate level. Hawkins provides dual-threat ability, leading the team in rushing yards (199) by barely edging out RB Cam Cook (194).

Speaking of Cook, a great deal of West Virginia’s offensive success could stem from his rushing ability this season. He's an electric back who's averaged 5.0 yards per carry throughout his career.

Defensively, the Mountaineers have defended the run quite well, allowing 0.00 EPA/rush (26th in the nation). In addition, West Virginia’s opponents are averaging just 3.1 YPC and have yet to reach the end zone.

West Virginia vs. Virginia Spread, Over/Under – Saturday, September 19

Virginia enters Saturday’s game as a 10.5-point favorite against West Virginia, via PrizePicks.

Here are the full payouts for West Virginia vs. Virginia, including winner payouts, the spread, and the over/under.

Make your West Virginia vs. Virginia prediction on the spread on PrizePicks.

PrizePicks data is live at the time of writing and is subject to change.

West Virginia vs. Virginia Prediction on Over/Under – 9/19/26

Here are the key game stats and trends behind our West Virginia vs. Virginia prediction on the over/under for the Saturday, September 19 matchup.

• The over is 7-3 in West Virginia’s last 10 games, including a 2-0 mark in 2026. Meanwhile, the over hit in Virginia’s win against Norfolk State in Week 2.
• Virginia has really thrived on third and fourth down, producing a 52.0% late-down success rate. Additionally, the Cavaliers average 6.15 yards to go on third down, good for eighth in the country.
• The Cavaliers’ rushing attack has thrived early in 2026, producing a 0.10 EPA/rush (52nd). RB Xay Davis leads the way with 120 yards (6.7 YPC) and a TD, while Pribula has notched 6.0 YPC.
• West Virginia got the job done on the ground against UT Martin last week, recording a staggering 316 rushing yards on 6.2 YPC. 
• Virginia has given up 130.0 passing YPG. However, it’s worth noting that NC State was Virginia’s most difficult opponent and ranked 101st in EPA/pass. 

Lock in your West Virginia vs. Virginia prediction on PrizePicks before kickoff.

West Virginia vs. Virginia Picks, Player Stats for PrizePicks: 9/19/26

Here are the top West Virginia vs. Virginia picks to target on Saturday, September 19. Today’s college football picks for PrizePicks include QB Beau Pribula and RB Cam Cook.

Virginia QB Beau Pribula vs. West Virginia: 189.5 Pass Yards

• Pribula completed 12 of 14 passes for 162 yards and 3 TDs against Norfolk State last week. The veteran QB played only the first half because Virginia held a 28-3 halftime lead. 
• The Virginia signal-caller is completing a career-high 84.0% of his passes on the year.
• West Virginia has yielded a 0.19 EPA/pass, ranking 106th in the nation.
• The Mountaineers cede 271.5 passing YPG, which is the most by any Big 12 team.

Add Beau Pribula + Virginia to cover the spread to your PrizePicks lineup now.

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West Virginia RB Cam Cook vs. Virginia: 94.5 Rush Yards

• Cook carried the ball 30 times for 142 yards (4.7 YPC) and 2 TDs in West Virginia’s season opener against Coastal Carolina.
• Virginia has allowed a 0.02 EPA/rush, which ranks 39th in the country.
• Cook rushed for at least 100 yards in 10 of his 13 games with Jacksonville State last season.
• The veteran RB led the nation in rushing yards (1,659) and was tied for fifth in rushing TDs (16) as a junior at Jax State.

Add Cam Cook + West Virginia to win to your PrizePicks lineup now.

Make West Virginia vs. Virginia Picks on PrizePicks

Both Virginia and West Virginia have proven playmakers on the offensive side of the ball. As a result, there could be plenty of points on the board in Charlottesville on Saturday night.

Don’t wait until kickoff — make your West Virginia vs. Virginia picks on PrizePicks now and earn real money if you’re right.

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