The end of the work week gives us something to look forward to on Friday night: a college football doubleheader to kickoff Week 4.
Below, we'll break down the top college football picks for CFB DFS on Friday, September 19, including the top player picks to target on PrizePicks.
There are two games on the college football schedule on Friday night, including a Big Ten matchup between Iowa and Rutgers. The Scarlet Knights have a chance to make program history and start 4-0 in back-to-back seasons for the first time since 1960-61.
Rutgers QB Athan Kaliakmanis is on a roll and is set to face his toughest challenge of the season against the stout Hawkeyes' defense.
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Friday CFB DFS Picks for Week 4 – Sept. 19, 2025
Here are the top Friday CFB DFS picks for Week 4 of college football on Friday, September 19, on PrizePicks. Use this analysis to build your PrizePicks CFB Lineups for Friday's games.
Rutgers QB Athan Kaliakmanis Projection: 214.5 Passing Yards
Iowa vs. Rutgers Pick – 8 p.m. ET
- Rutgers QB Athan Kaliakmanis has thrown for over 250 yards in all three games this year, but he has yet to face a Power Four opponent.
- Iowa is seventh in passing yards allowed per game this season (113.5).
- Iowa has finished inside the top ten in passing yards allowed per game in two of the last three seasons.
- Last year, Kaliakmanis threw for more than 215 yards twice against Power Four opponents ranked inside the top 80 in passing yards allowed per game; one of those games was against Minnesota, whom he had played for the previous season.
- Iowa is 37th in sacks per game (2.5).
- Rutgers is 63rd in sacks allowed (2.0).
Iowa RB Jaziun Patterson Projection: 44.5 Rushing Yards
Iowa vs. Rutgers Pick – 8 p.m. ET
- Iowa is 38th in run play percentage (56.83%).
- After RB Xavier Williams led all Iowa running backs in snaps in Week 1 against Albany, Iowa RB Jaziun Patterson has led in snaps the past two games. This is because Williams injured his shoulder and left last week's matchup vs. UMass with a shoulder injury.
- Williams is not expected to play on Friday vs. Rutgers. However, RB Kamari Moulton is expected to play after missing last week’s matchup against UMass with an injury.
- Patterson has 136 yards after contact on 28 carries; only six other running backs in the FBS have more with fewer carries.
- Rutgers is 83rd in rushing yards allowed per game (159.0).
- Rutgers is 118th in overall defensive EPA (0.011).
- Rutgers has allowed two separate players to rush for over 50 yards in two of three games this season, including last week against FCS program Norfolk State.
Oklahoma State RB Kalib Hicks: 68.5 Rushing Yards
Tulsa vs. Oklahoma State Pick – 7:30 p.m. ET
- Oklahoma State RB Kalib Hicks has yet to rush for more than 63 yards this season.
- Hicks spent the previous two seasons with Oklahoma and saw very little playing time. He had 5 carries for 25 yards in that span.
- In the 69-3 Week 2 loss to Oregon, 50 of Hick’s 63 rushing yards came on the final drive of the game when Oregon was playing their reserves.
- According to PFF, Oklahoma State’s offensive line is rated 83rd in run blocking grade (58.3).
- Tulsa is 116th in rushing yards allowed per game (205.0), and 72nd in rush EPA against.
- In Tulsa’s Week 3 loss to Navy, they were unable to stop Navy’s slow-paced triple-option offense. Navy is 129th in seconds between plays (31.0) while Oklahoma State is 121st (29.8).
Tulsa RB Dominic Richardson: 76.5 Rushing Yards
Tulsa vs. Oklahoma State Pick – 7:30 p.m. ET
- Tulsa RB Dominic Richardson had less than 90 rushing yards for the first time this season in last week’s 42-23 loss to Navy.
- The game script went against Richardson in that game, as he only had 4 carries in the second half.
- This is a revenge game for Richardson, who played for Oklahoma State from 2020 to 2022.
- Oklahoma State is second-to-last in the FBS in rushing yards allowed per game (312.0).
- In the 69-3 Week 2 loss to Oregon, Oklahoma State allowed two players to run for over 80 yards.
Make Week 4 CFB DFS Picks on PrizePicks
Friday night bring us two college football games, including a Big Ten matchup between Iowa and Rutgers. The other matchup features Oklahoma State, who will try to regroup after an embarrassing 66-point loss to Oregon when the Cowboys face in-state rivals Tulsa.
No matter how you think this game plays out, there's no better way to cash in on your college football picks with PrizePicks' real money CFB DFS game.
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Check out the Playbook for more CFB DFS picks and college football predictions throughout the season!
