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It'll be an NFC East clash between the Washington Commanders and New York Giants on Thursday Night Football to kick off Week 10. Ahead of Thursday’s action, it’s important to keep tabs on injury news and players’ roles to make Start ‘Em, Sit ‘Em decisions in fantasy football.
If you tend to stress over lineup decisions or wait until the last minute, look no further than our Week 10 fantasy football rankings.
Below, we’ll highlight the best fantasy football options at each position in Week 10, including quarterbacks, running backs, wide receivers, tight ends, and defense/special teams.
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All fantasy football rankings below use PrizePicks NFL fantasy scoring, which includes one point per reception (PPR). Players who historically catch more passes should get a slight discount if you are in non-PPR leagues.
Week 10 Quarterback Rankings
Here are our Week 10 quarterback rankings for the 2026 fantasy football season.
Make NFL Week 10 predictions on PrizePicks — including pass yards and TDs!
Week 10 Running Back Rankings
Here are our Week 10 running back rankings for the 2026 fantasy football season.
Make NFL Week 10 predictions on PrizePicks — including rush yards and TDs!
Week 10 Wide Receiver Rankings
Here are our Week 10 wide receiver rankings for the 2026 fantasy football season.
Make NFL Week 10 predictions on PrizePicks — including rec yards and TDs!
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Week 10 Tight End Rankings
Here are our Week 10 tight end rankings for the 2026 fantasy football season.
Make NFL Week 10 predictions on PrizePicks — including rec yards and TDs!
Week 10 Defense/Special Teams Rankings
Here are our Week 10 defense and special teams rankings for the 2026 fantasy football season.
Make NFL Week 10 predictions on PrizePicks — including sacks and teams to win!
Make 2026 NFL Predictions on PrizePicks
Before Week 10’s slate of games begins, the notable injuries throughout the league include QB Patrick Mahomes, RBs Bhayshul Tuten, David Montgomery, Cam Skattebo, and WRs Garrett Wilson, Mike Evans, George Pickens, Carnell Tate, Denzel Boston, Ladd McConkey, and Deebo Samuel.
With Week 10 of the 2026 NFL season arriving, which players should you insert in your fantasy football lineups?
Don’t wait until kickoff — make your 2026 NFL Week 10 picks on PrizePicks now.
Just pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on NFL game winners, spreads, over/unders, and award futures, now available in 36 states.
Stay locked in on Playbook for NFL predictions, picks, and news all the way through Super Bowl LXI.
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