Start ‘Em, Sit ‘Em, NFL Week 10: Back Zach Charbonnet, Fade Ashton Jeanty?

Depending on your league, about four or five games remain in most fantasy football regular seasons. The playoff push is here, and that means high-pressure situations for your Start ‘Em, Sit ‘Em decisions for NFL Week 10.

Few teams can afford a loss right now, and if you can, pat yourself on the back. Several fantasy football pieces continue to provide frustrating results, like the entire Vikings offense. It could be time to sit key players, even if they cost you a high draft pick. 

Let’s dig into our NFL Week 10 Start ‘Em, Sit ‘Em, breaking down each player’s upcoming matchup and projections on PrizePicks.

Make NFL picks for Week 10 on PrizePicks! 

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Start ‘Em, Sit ‘Em, NFL Week 10

We’ve got several surprising sits ahead, with several premium fantasy football draft picks pulling tough matchups in Week 10. However, two of our starters in Week 10’s Start ‘Em, Sit ‘Em are available in over 76.0% of leagues, meaning you can find a replacement on this week’s waiver wire. 

We’ll cover the good and bad for each major position group for full-PPR leagues, including quarterbacks, running backs, wide receivers, and tight ends.

Here’s who you should start and who should warm the bench for Week 10’s Start ‘Em, Sit ‘Em.

Start ‘Em, Sit ‘Em: Quarterbacks

Across the fantasy football season, Commanders QB Jayden Daniels has posted 19.2 fantasy points per game (FPPG), compared to Saints QB Tyler Shough’s 19.0 — ranking the two as QB8 and QB12 this season. Who should be in your lineup for Week 10’s Start ‘Em, Sit ‘Em?

Saints QB Tyler Shough: Start ‘Em

Game: Panthers vs. Saints – Sunday, November 15, 1:00 p.m. ET

Projections via PrizePicks: 236.5 Pass Yards, 23.5 Pass Completions, 1.5 Pass TDs

Through three weeks of the season, Shough looked like the next fantasy football star, racking up 24.1 FPPG in the split. Many managers were far too quick to take their victory lap for finding a “steal” late in fantasy drafts (myself included). 

Since Week 4, Shough is down to 15.8 FPPG, sitting as QB18 in the split. That’s not nearly good enough to earn a starting spot, but we’ve got good news after Week 9.

Shough comes off one of his better outings since early in the season, recording 265 passing yards, 1 passing TD, 51 rushing yards, and 19.7 fantasy points (QB8). His season-high 10 rushing attempts was particularly intriguing. 

The Saints have searched for any kind of efficiency in the run game, averaging just 3.8 yards per carry (27th). After Shough added a wrinkle with 5.1 YPC in Week 9, this would add a ton of potential to his fantasy stock.

According to Pro Football Reference, the Panthers have allowed 146 rushing yards vs. QBs (13th most). Further, Carolina just allowed 16.7 fantasy points and a QB11 finish to Broncos QB Bo Nix. In Week 8, Packers QB Jordan Love recorded 288 passing yards, 3 passing TDs, and 22.5 fantasy points (QB6) vs. the Panthers.

Shough should have plenty of chances to take advantage, as seen by New Orleans’ 61.77% pass play rate (sixth). 

Add Tyler Shough to your PrizePicks lineup.

Commanders QB Jayden Daniels: Sit ‘Em

Game: Commanders vs. Giants – Thursday, November 12, 8:15 p.m. ET

Projections via PrizePicks: 202.5 Pass Yards, 34.5 Rush Yards, 0.5 Anytime TDs (Demon)

After returning from an elbow injury, Jayden Daniels posted 32.3 (QB2) and 21.0 fantasy points (QB7). Following Week 7’s bye, Daniels followed those performances with only 15.0 (QB16) and 14.6 points (QB14).

Daniels had his best fantasy football game of the season vs. the Giants in Week 5, recording 32.3 fantasy points. However, he had 199 passing yards and 0 passing TDs, as his 9 carries for 103 rushing yards and 2 rushing TDs carried the load. 

Since then, Daniels had 4, 2, and 4 rushing attempts in his last three. I wouldn’t go into this one expecting a ton of rushing volume for Daniels. And if that’s the case, this quickly turns into a challenging matchup. 

The Giants allow only 6.0 yards per passing attempt (second) and a 42.3% dropback success rate (fifth), per RBSDM. That gets even more challenging when New York has a 61% pass rush rate, per ESPN.

Giants EDGE Abdul Carter has 20 pressures in his last five, via Pro Football Focus, and rookie LB Arvell Reese continues to turn heads with 4 sacks in his last two — including 3 in Week 9. This is quickly becoming a very young, talented defense, further backed by fourth-year CB Deonte Banks’ 40.6% lockdown rate (seventh), per FTN.

Adding to Daniels’ trouble, his receiving corps is extremely banged up. Commanders WR Terry McLaurin is out for the season, while WR Treylon Burks (foot) and TE Chig Okonkwo (hip) are battling injuries on a short week.

Make Jayden Daniels picks on PrizePicks now!

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Start ‘Em, Sit ‘Em: Running Backs

The Seahawks and Raiders square off for a matchup in NFL Week 10, and we’re looking at RBs from each team in this week’s Start ‘Em, Sit ‘Em.

Seahawks RB Zach Charbonnet: Start ‘Em

Game: Seahawks vs. Raiders – Sunday, November 15, 4:05 p.m. ET

Projections via PrizePicks: 54.5 Rush Yards, 10.5 Receiving Yards, 13.5 Rush Attempts

After tearing his ACL last postseason, Zach Charbonnet is now two games removed from his 2026 season debut. He logged a 36.5% snap share in Week 8 and saw that jump to 56.7% only one week later.

It was Seattle’s first chance to test the workload with Charbonnet and rookie RB Jadarian Price each in full roles, and the veteran took most of the work in the run game. Charbonnet had 16 carries for 77 rushing yards (4.8 YPC) compared to Price’s 9 for 24 yards (2.7 YPC).

Price continues to struggle in efficiency on the ground with 3.7 yards per rushing attempt, though his 3.09 yards after contact per carry is solid. But even Charbonnet crushes that, courtesy of 3.73. 

The rookie took the bulk of receiving work: 4 targets, 4 catches, and 54 receiving yards. While Charbonnet had only 1 reception for 9 yards, his 19 pass snaps compared to Price’s 11 suggest he has PPR upside as well. 

It appears the Seahawks are mostly leaning on Charbonnet, even after a major knee injury. That may mean a big-time Week 10 outing vs. a Raiders defense allowing 24.2 FPPG to RBs (fourth most) and 5.0 yards per carry (31st). 

Predict More or Less for Zach Charbonnet’s rush yards projection on PrizePicks! 

Raiders RB Ashton Jeanty: Sit ‘Em

Game: Seahawks vs. Raiders – Sunday, November 15, 4:05 p.m. ET

Projections via PrizePicks: 35.5 Rush Yards Yards, 30.5 Receiving Yards, 10.5 Rush Attempts

On the flip side, I’m fading Raiders RB Ashton Jeanty. He’s carried alarming efficiency most of the season, and now rookie RB Mike Washington Jr. is digging into his workload. Jeanty has 4.7 FPGG over his last two.

Since Week 8, Washington logged 31 carries compared to Jeanty’s 8. However, one has to wonder how long this continues considering Washington’s 2.6 YPC in that split. Regardless, Jeanty is in trouble vs. an elite Seahawks defense.

Among RBs with at least 88 rushing attempts on the season, Jeanty’s 2.70 yards after contact per carry is 23rd out of 28 qualifying RBs. His 11 forced missed tackles are even worse, placing 27th across the NFL.

Seattle, meanwhile, allow 3.4 YPC (second), boast a 25.1% run stuff rate (fourth), and yield a 34.9% rush success rate (fifth). The unit allows only 0.8 rushing TDs per game (11th), and it’s already difficult enough to score vs. a defense allowing 18.0 PPG (fourth).   

What is there to like about this matchup? The Raiders are 3.5-point underdogs on the spread, via PrizePicks, and I can see this quickly getting out of hand with a negative game script. Most of Jeanty’s upside will likely serve PPR leagues, as his 17.3% target share is third among RBs, per PlayerProfiler. 

Make Ashton Jeanty picks on PrizePicks now!

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Start ‘Em, Sit ‘Em: Wide Receivers

We’ve got a rookie vs. an established veteran for Week 10’s Start ‘Em, Sit ‘Em at WR. Does Dolphins WR Caleb Douglas have a case to start over Steelers WR DK Metcalf? 

Dolphins WR Caleb Douglas: Start ‘Em

Game: Dolphins vs. Colts – Sunday, November 15, 1:00 p.m. ET

Projections via PrizePicks: 43.5 Receiving Yards, 0.5 Anytime TDs (Demon)

Right off the bat, Caleb Douglas benefits from facing one of the worst teams in football, the Indianapolis Colts. They allow 27.7 PPG (30th), 6.1 yards per play (32nd), and 8.1 yards per passing attempt (30th). 

Dolphins QB Malik Willis was dealing with a groin injury in Sunday’s game vs. the Lions. That’s something to monitor ahead of this matchup, but Willis finished the game with a 100.0% snap rate.

Miami’s 15.8 PPG (31st) doesn’t generate much confidence initially, but Willis’ 0.115 adjusted EPA per play is 16th among 33 qualifying QBs since Week 7. The Phins have more reason to air it out with Douglas healthy. 

Following Week 7’s 21.0 fantasy points (WR12) with 2 catches for 70 receiving yards and 2 receiving TDs, the rookie has seen his volume increase to 7.0 targets per game over the last two. Best of all? He’s rostered in only 25.5% of leagues.

Douglas’ 2.26 yards per route run leads the Dolphins by a mile, with WR Malik Washington’s 1.62 as the next-best mark. When he’s already producing 6.7 yards after the catch per reception, expect Douglas to get more and more involved in this offense.

Pick More or Less for Caleb Douglas’ projections on PrizePicks. 

Steelers WR DK Metcalf: Sit ‘Em

Game: Steelers vs. Bengals – Sunday, November 15, 8:20 p.m. ET

Projections via PrizePicks: 52.5 Receiving Yards, 0.5 Anytime TDs (Demon), 11.5 Fantasy Score

Week 10’s primetime games are far from appetizing, including the Commanders vs. Giants for Thursday Night Football and the Chargers vs. Ravens for Monday Night Football. Fortunately, not all is lost thanks to the Steelers and Bengals colliding on Sunday Night Football.

Both teams are 6-2 and atop the AFC North standings. According to PrizePicks, the Bengals have the shortest payout to win the division (1.51x), followed by the Steelers (3.03x). In the previous matchup, Pittsburgh won 30-27 in Week 3.

Despite the Steelers totaling 30 points and 411 yards of offense in the win, DK Metcalf still provided minimal production with 5 targets, 3 catches, 31 receiving yards, 1 TD, and 12.1 fantasy points (WR35). That’s a running theme this season, proven by his 9.7 FPGG (WR43). 

Metcalf’s fantasy performance in Week 3 was saved by a touchdown, and that’s not something to expect due to a 14.3% red zone target share (55th). Following 1.5 catches, 30.0 receiving yards, and 4.5 FPPG in his last two, there isn’t much upside to placing Metcalf in your fantasy football lineup right now.

Worries around production only get worse when looking at his potential one-on-one matchup vs. Bengals CB DJ Turner II. I’ll say it again and again; this is one of the most underrated players in football. 

Among 71 eligible CBs, Turner’s 10.3 snaps per target is second, and his 15.7 snaps per reception is 13th. He isn’t targeted often, and Turner carries an impressive 17% forced incompletion rate (tied for 14th).

Furthermore, Metcalf’s upside is mostly held by air yards (41.0% air yards share), and Cincinnati has an 8.0% sack rate (fourth) that may lower Steelers QB Aaron Rodgers’ uninspiring 7.4 average depth of target (aDOT) — proven by his 5.0 aDOT vs. the Bengals in Week 3.

Add DK Metcalf to your PrizePicks lineup for Week 10.

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Start ‘Em, Sit ‘Em: Tight Ends

Vikings TE T.J. Hockenson has the misfortune of dealing with a QB carousel, while Panthers TE Darren Waller is like a roller coaster due to up-and-down play. Which vet can we trust for our Start ‘Em, Sit ‘Em TEs in NFL Week 10? 

Panthers TE Darren Waller: Start ‘Em

Game: Panthers vs. Saints – Sunday, November 15, 1:00 p.m. ET
Projections via PrizePicks: 28.5 Receiving Yards, 0.5 Anytime TDs (Demon)

Darren Waller has flashed throughout the season, reaching 10.0 fantasy points in four of eight games. In those other four contests? He averaged only 3.8 FPPG.

Waller is boom-or-bust at the tight end position; he’s a nice streaming option or bench piece. The ability to start the veteran TE will depend on his matchup most of the time, unless you’re in a tight spot and need a starter no matter what.

Currently, Waller could be entering the best stretch of the season. He had his best game vs. the Broncos in Week 9, tallying season highs in targets (10), receptions (8), and receiving yards (90). Plus, Waller found the end zone in a 23.0 fantasy point outburst (TE1).

The 34-year-old target has an enticing 9.4 aDOT (fourth) on an offense with a 64.20% pass play rate (first). The Panthers face the Saints this week, and New Orleans allows 7.8 yards per passing attempt (24th), a 48.3% pass success rate (23rd), and 13.5 FPPG vs. TEs (seventh most).

Following Week 10, Waller benefits from matchups vs. the Ravens and Buccaneers, who are each in the top half for the most FPPG allowed to TEs.

Make Darren Waller picks on PrizePicks now!

Vikings TE T.J. Hockenson: Sit ‘Em

Game: Vikings vs. Packers – Sunday, November 15, 1:00 p.m. ET
Projections via PrizePicks: 0.5 Anytime TDs (Demon)

T.J. Hockenson recorded 10.7 FPPG over Weeks 7 and 8, but if you tuned into Week 9’s Monday Night Football, you can probably guess why the veteran tight end is a sit.

I want absolutely no part of this Minnesota offense. WR Justin Jefferson is the only exception, and even he has produced way below his potential with 11.9 FPG (WR31). If the Vikings can nerf Jetas — one of the league’s best WRs — Hockenson isn’t in the best situation. 

We could go on and on about what’s holding this Vikings team back, leading to back-to-back losses, but ultimately it’s QB play. Vikings QB Kyler Murray has a 40.6% success rate that’s 28th out of 31 eligible QBs, and he’s battling a Grade 2 hamstring strain that could lead to an extended absence.

QB Carson Wentz was so bad on Monday Night Football that he was benched. The veteran had -0.933 adjusted EPA per play (30th), a 25.0% success rate (30th), and a -30.7% completion percentage over expectation (30th). The next-lowest mark in CPOE for Week 9 was -12.0%...

Wentz was laughably bad against a below-average Bills defense, featuring 3 turnovers in a 23-6 loss. September’s trade of QB J.J. McCarthy to the Giants looks worse by the day. 

According to ESPN’s Adam Schefter, Minnesota is calling about QBs ahead of the trade deadline, but until the Vikings have any semblance of decent QB play, Hockenson is simply a sit. 

This decision is further elevated by the Packers allowing only 7.5 FPPG to TEs (second fewest), and Green Bay limits teams to 4.9 yards per play (fifth) and forces 2.1 takeaways per contest (second). 

Add T.J. Hockenson to your PrizePicks lineup for NFL Week 10.

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Turn Your Fantasy Football Takes to NFL Picks on PrizePicks

Several premium fantasy football draft picks may need to sit on your bench in Week 10, including Ashton Jeanty and Jayden Daniels. Fortunately, we have several potential Week 10 starters available on the waiver wire, like Caleb Douglas and Darren Waller.

You can turn your fantasy football knowledge into picks on PrizePicks! Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on NFL game winners, spreads, and over/unders — now available in 36 states. 

As we head into the NFL season, stay locked in Playbook for weekly NFL start/sit advice, waiver wire analysis, and game picks throughout the 2026 NFL season.