Waiver Wire Week 10 for Fantasy Football: Seth McGowan, Tank Dell Must-Adds?

Another week of football is behind us, and depending on your league, four or five weeks remain before the fantasy football playoffs. We are officially entering the playoff push, and NFL Week 10 provides an intriguing opportunity to boost your roster on the waiver wire.

The NFL trade deadline is on Tuesday, November 10, at 4:00 p.m. ET. We’ve seen significant trades on defense, featuring DT Jeffrey Simmons landing with the Bears, while the Jaguars acquired S Jessie Bates III on Monday morning. Moves on offense are inevitable, especially when Colts RB Jonathan Taylor, Colts WR Josh Downs, and Jaguars WR Brian Thomas Jr. are hot in trade rumors.

A change of scenery is just what some players need, while trades would also open new roles for fantasy football. Here are the top waiver wire adds for NFL Week 10 with the looming trade deadline in mind.

Make NFL Week 10  picks on PrizePicks! 

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Waiver Wire Pickups for Week 10: Colts Front and Center for NFL Trade Deadline 

We’ve got familiar faces for the Week 10 waiver wire, including a veteran QB. A wide receiver coming off an extended absence from injury had a breakout in Week 9, and several waiver wire targets should receive extra attention due to the trade deadline, especially on the Colts and Cowboys. 

For each waiver wire target, we’ll highlight their Week 10 matchup and projections on PrizePicks, followed by a fantasy football roster percentage via FantasyPros. Keep in mind each weekly positional ranking provided for Week 9 does not account for Monday Night Football between the Bills and Vikings.

Top Quarterback Waiver Wire Pickups for Week 10

Due to QB Deshaun Watson’s absence, Browns QB Shedeur Sanders got his first start of the season and turned heads. The Steelers, meanwhile, come off bye for a pivotal Week 10 AFC North battle vs. the Bengals, and QB Aaron Rodgers shredded Cincinnati last time around. 

Steelers QB Aaron Rodgers

Week 10 Matchup: vs. Bengals

Roster Percentage: 34.4%

Aaron Rodgers was on bye in Week 9, and the last time we saw the 42-year-old QB, he posted 13.1 (QB21) and 5.9 fantasy points (QB25) in his past two performances. 

However, from Weeks 3 to 6, Rodgers recorded 21.7 fantasy points per game (FPPG). That hot streak began with 292 passing yards, 3 passing TDs, 1 INT, and 23.7 fantasy points (QB8) in Week 3 vs. the Bengals. After winning the first head-to-head matchup 30-27, Rodgers looks to run it back vs. Cincinnati, with both teams 6-2 atop the AFC North.

Frankly, Rodgers is nothing more than a week-to-week streaming option for fantasy football. But he checks that box for Week 10. The Steelers continue to offer a helpful 61.86% pass play rate (fifth). The Bengals allow 5.7 yards per play (27th) and 7.3 yards per passing attempt (20th).

Make Aaron Rodgers picks on PrizePicks for NFL Week 10.

Browns QB Shedeur Sanders

Week 10 Matchup: vs. Texans

Roster Percentage: 4.3%

After Week 9’s 23-22 loss in overtime vs. the Saints, Shedeur Sanders was asked if he earned the right to start.

He definitely did his part, producing 297 passing yards, 9.6 yards per attempt, 2 passing TDs, and 22.7 fantasy points (QB5). According to RBSDM, Sanders’ 0.110 adjusted EPA per play ranked 11th in Week 9 among 28 eligible QBs (minimum 20 plays) before Monday Night Football.

While it’s a limited sample size, Sanders completed 3 of 3 passing attempts of over 20 yards with an average depth of target (aDOT) of 34.7 yards on those passes, per Pro Football Focus. In comparison, Browns QB Deshaun Watson has completed only 10 of 29 20+ yard attempts with a 37.9% adjusted completion percentage in that split. 

According to ESPN’s Jeremy Fowler, Cleveland plans to start Watson vs. the Texans in Week 10. However, Sanders remains an intriguing storyline to monitor in the upcoming weeks. 

Predict More or Less for Shedeur Sanders’ pass yards on PrizePicks.

Other Week 10 QB Waiver Wire Pickups to Target

• Seahawks QB Drew Lock (vs. Raiders): 8.2% roster percentage
• Jets QB Geno Smith (vs. Bills): 21.8% roster percentage‍
• Ravens QB Jacoby Brissett (vs. Chargers): 16.9% roster percentage‍
• Cardinals QB Carson Beck (vs. Rams): 2.5% roster percentage

Top Running Back Waiver Wire Pickups for Week 10  

The Colts and Saints continue to tinker with their workload in backfields, and that leads to clear RB waiver wire targets for Week 10. 

Colts RB Seth McGowan

Week 10 Matchup: vs. Dolphins

Roster Percentage: 18.7% 

Colts RB Jonathan Taylor has been in trade rumors for weeks since Indianapolis in sell mode ahead of the deadline. While a move is still up in the air, Taylor commented on the situation following Sunday’s 27-23 loss vs. the Cowboys. 

With a move, that may boost Taylor’s fantasy stock, and Seth McGowan would likely become the Colts’ clear starting running back. I’ve suggested claiming McGowan for weeks, and his 18.7% roster percentage will skyrocket if Taylor is moved.

We’ve gotten sample sizes of what McGowan can do, as the rookie carries a 27.6% snap rate since Week 4. In that split, he has tallied 5.2 yards per carry. According to FTN, McGowan’s 3.19 yards after contact per carry and 66.4% rush creation rate surpass Taylor’s 2.74 and 63.9%. 

McGowan scored his first touchdown of his career on Sunday, and red zone work would inevitably increase if Taylor is traded. While the Colts’ offense provides few scoring chances, getting a potential starting RB for fantasy football at this stage of the season should be highlighted and circled for the waiver wire.

Lock in Seth McGowan picks on PrizePicks for NFL Week 10.

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Saints RB Audric Estime

Week 10 Matchup: vs. Panthers

Roster Percentage: 7.3% 

The Saints continue to deal with injuries in the backfield, as RB Travis Etienne (hamstring) has been on injured reserve since his last game in Week 3. New Orleans has yet to activate his 21-day practice window off IR, and RB Alvin Kamara has tallied only 3.3 yards per carry this season.

RB Kendre Miller was getting work with 57 attempts for 2.8 YPC on the season. Following his struggles, the Saints released Miller after signing RB Audric Estime over the weekend.

In Estime’s first game in New Orleans, he immediately took a 46.7% snap share with 15 carries for 72 rushing yards, 1 rushing TD, and 14.7 fantasy points (RB9). Kamara had a 49.3% snap share while taking 6 rushing attempts, 4 targets, and 3 receptions. 

Estime received only 1 target in the 23-22 win over the Browns. This could be the workload until Etienne returns from injury; Estime takes most of the work on the ground, while Kamara is a third-down tailback. 

Most importantly, the Saints may have finally found an efficient running back, proven by Estime producing 4.8 YPC on Sunday. 

Add Audric Estime to your PrizePicks lineup for NFL Week 10.

Other Week 10 RB Waiver Wire Pickups to Target

• Patriots RB Corey Kiner (vs. Lions): 5.3% roster percentage
• Packers RB Kaleb Johnson (vs. Vikings): 1.6% roster percentage
• Browns RB Dylan Sampson (vs. Texans): 27.5% roster percentage
• Bengals RB Samaje Perine (vs. Steelers): 10.4% roster percentage
• 49ers RB Kaelon Black (Cowboys): 32.1% roster percentage

Top Wide Receiver Waiver Wire Pickups for Week 10

Week 10’s waiver wire features a promising crop of wide receivers. 

If available, Saints WR Jordyn Tyson (58.0% roster rate) should be picked up. He finally made his debut in Week 9 after beginning the season on IR. As expected for the #8 pick of the 2026 NFL Draft, New Orleans made a clear effort to get the rookie involved, with Tyson receiving 5 targets in a limited 24.0% snap share.

We’ll focus on more widely available receivers, rostered in 45.0% or less. Texans WR Tank Dell erupted in his second game back from injury, Dolphins WR Caleb Douglas continues to produce, and Cowboys WR Ryan Flournoy is seeing an increased role.

Texans WR Tank Dell

Week 10 Matchup: vs. Browns

Roster Percentage: 22.9% 

Week 9 showed exactly how the Texans could get hot and make a playoff push — ride an electric passing attack. Texans QB C.J. Stroud racked up 384 passing yards and 5 passing TDs with 0.572 adjusted EPA per play (second in Week 9).

That meant Houston’s entire receiving corps ate, but Tank Dell’s workload stood out among the bunch. In his second game back from 2024’s devastating knee injury, Dell saw Week 7’s 23.0% snap share jump to 47.1% in Week 9. That’s as expected for a player coming off a major injury.

WR Marvin Harrison Jr. also saw his 19.0% and 21.3% snap shares from his first two games as Texan increase to 45.7% on Sunday. Dell and Harrison are both worth monitoring going forward, but Dell takes the cake thanks to 9 targets, 4 catches, 105 receiving yards, 1 receiving TD, and 20.5 fantasy points in Week 9 (WR8).  

Make Tank Dell picks on PrizePicks for NFL Week 10.

Dolphins WR Caleb Douglas

Week 10 Matchup: Colts

Roster Percentage: 25.2% 

Caleb Douglas missed three games due to an ankle injury early in the season, but when the rookie has been on the field, he’s been extremely productive.

On Sunday, Douglas had 8 targets, 6 receptions, 70 receiving yards, and 13.0 fantasy points (WR26). Since returning from injury in Week 7, he’s up to 5.7 targets, 4.0 receptions, 61.0 receiving yards, and 14.1 FPPG — which is WR14 since Week 7.

According to PlayerProfiler, Douglas has an 81.4% snap share (21st), a 78.6% route rate (36th), an 18.4% target share (41st), and a 28.0% air yards share (38th). Since Week 7, the rookie has enjoyed 10.7, 13.3, and 12.5 aDOTs. Paired with 7.1 yards after the catch per reception in this three-game split, it’s time to buy Douglas stock.

Lock in Caleb Douglas picks on PrizePicks for NFL Week 10.

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Cowboys WR Ryan Flournoy

Week 10 Matchup: vs. 49ers

Roster Percentage: 43.0% 

Cowboys WR Ryan Flournoy has quickly become a popular waiver wire target due to WR George Pickens trade rumors. That accelerated when Pickens sat out due to a hamstring injury in Week 9.

However, Pickens trade expectations were continuously hushed leading up to Week 9. Dallas is operating as if Pickens will remain on the team, with head coach Brian Schottenheimer commenting on Pickens’ health following Sunday’s game. We’re reading the tea leaves here, but claiming Flournoy may not be centered around a Pickens trade.

Instead, this is simply about exceptional play leading to a larger role. Flournoy’s 24.2% missed tackle rate is among the league’s most elite targets, and he has a strong 0.328 EPA per target and 37.8% separation rate — which is ahead of WR CeeDee Lamb’s 31.9%. 

Since Week 5, Flournoy has averaged 12.1 FPPG, ranking as WR17 in that split. Before Pickens sat out on Sunday, Flournoy already touted a high 73.8% snap share, and that jumped to 97.5% on Sunday. 

If Pickens continues to miss time, Flournoy could be a clear fantasy starter.

Make Ryan Flournoy picks on PrizePicks for NFL Week 10.

Other Week 10 WR Waiver Wire Pickups to Target

• Commanders WR Antonio Williams (vs. Giants): 22.1% roster percentage
• Broncos WR Pat Bryant (Bye): 3.8% roster percentage
• Rams Konata Mumpfield (vs. Cardinals): 3.% roster percentage
• Jaguars WR Brian Thomas Jr. (vs. Titans): 41.2% roster percentage
• Jaguars WR Travis Hunter (vs. Titans): 16.3% roster percentage
• Bills WR Keon Coleman (vs. Jets): 29.5% roster percentage
• Texans WR Kayshon Boutte (Browns): 22.9% roster percentage
• 49ers WR Jordan Watkins (vs. Cowboys): 2.2% roster percentage 

Top Tight End Waiver Wire Pickups for Week 10

A starting tight end on one of the league’s best offenses headlines our tight end waiver wire target for Week 10.

Bengals TE Mike Gesicki

Week 10 Matchup: vs. Steelers

Roster Percentage: 37.9% 

Mike Gesicki is TE12 this season, boasting 6 receiving TDs over eight games. His 11.1 aDOT is first among eligible TEs, and that’s like gold on a Bengals offense featuring 30.0 PPG (second) and a 63.73% pass play rate (third).

According to PrizePicks, Bengals QB Joe Burrow has the shortest payout to win NFL MVP (3.22x) before Monday Night Football between the Bills and Vikings. Buffalo QB Josh Allen (3.44x) is currently in a tight race with Burrow, followed by 49ers QB Brock Purdy (5.26x) and Packers QB Jordan Love (5.55x).

In summary, any exposure to Burrow and this passing attack is extremely valuable for your fantasy football roster. Somehow, Gesicki is still among waiver wire options. 

When he scores (six of eight games), Gesicki produces 12.9 FPPG. When he hasn’t found the end zone in two contests, the veteran TE had 1.6 FPPG. Gesicki has clear boom-or-bust qualities, but his exposure to this Bengals offense still warrants a roster spot. 

Predict Mike Gesicki stats on PrizePicks for NFL Week 10.

Other Week 10 TE Waiver Wire Pickups to Target

• Steelers TE Pat Freiermuth (vs. Bengals): 35.4% roster percentage
• Commanders TE Chig Okonkwo (vs. Giants): 24.0% roster percentage
• Dolphins TE Greg Dulcich (vs. Colts): 9.3% roster percentage
• Panthers TE Darren Waller (vs. Saints): 9.6% roster percentage

Top Defense (D/ST) Waiver Wire Pickups for Week 10

Heading into Week 10, we’ve got two D/ST streaming options for the waiver wire. The Packers face the Vikings, while the Giants defend their NFC East lead vs. the Commanders on Thursday Night Football. Which unit is the best waiver wire target? 

Packers Defense

Week 10 Matchup: vs. Vikings

Roster Percentage: 31.5% roster percentage 

The Packers D/ST sits as the seventh-best unit in fantasy football, yet it’s rostered in only 31.5% of leagues ahead of NFL Week 10. That’s the nature of the beast in fantasy football; even the most elite units like the Vikings will become available due to managers streaming weekly.

Green Bay’s last five matchups featured quality offenses: Bears, Cowboys, Lions, Panthers, and Patriots. But that span is when the Packers D/ST became fantasy relevant with 11.2 FPPG — ranking as D/ST2 since Week 5.

That’s courtesy of 3.2 sacks and 3.0 forced turnovers per game in the split. The unit has produced on this level without 1 defensive TD, and up next is a Vikings offense logging 20.0 PPG (26th) and 4.7 yards per play (28th) while sporting a 9.81% sack rate allowed (28th) — all marks before Monday night’s game vs. the Bills. 

This unit is only going to improve with Packers EDGE Micah Parsons expected to make his season debut in Week 12, adding to the Green Bay’s upside with the longest payout to win the NFC North (6.25x), per PrizePicks. For now, the Packers D/ST is a must-play vs. the Vikings in Week 10.

Make your Vikings vs. Packers picks on PrizePicks!

Other Week 10 D/ST Waiver Wire Pickups to Target

• Giants D/ST (vs. Commanders): 19.6% roster percentage

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Make NFL Week 10 Picks on PrizePicks

Week 10’s waiver wire is led by a strong group of RBs and WRs — two premium positions for fantasy football. If Jonathan Taylor is traded, Seth McGowan becomes the gem of this week’s waiver wire, and don’t sleep on high workloads for Audric Estime, Tank Dell, Caleb Douglas, and Ryan Flournoy.

Don’t wait until kickoff — make your NFL Week 10 picks on PrizePIcks now! You can make picks on the winner, spread, and over/under on PrizePicks Team Picks, now available in 36 states. With PrizePicks, just pick players and predict More or Less on their stats!

Keep it locked in here with the Playbook for continued NFL picks, predictions, and news all season long.