#18 USC vs. #9 Indiana Prediction, Spread, NCAAF Picks – Saturday, November 14

A pivotal matchup that could shape the late-season Big Ten standings takes place on Saturday when the Indiana Hoosiers host the USC Trojans on Saturday, November 14, with the game kicking off at 3:30 p.m. ET on CBS. The Hoosiers are a 9.5-point favorite on the spread, via PrizePicks.

Indiana escaped with back-to-back overtime wins prior to its bye week and sits at 8-1 this season. Meanwhile, USC knocked off then-#2 Ohio State on Halloween to move to 7-2. Per ESPN, these teams have respective 75.6% and 14.0% chances to make the College Football Playoff entering the weekend.

Below, we’ll break down our USC vs. Indiana prediction and picks for Saturday afternoon’s game, including the spread, over/under, and key player projections for PrizePicks. 

Make your USC vs. Indiana picks on PrizePicks now!

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#18 USC vs. #9 Indiana Prediction, Spread, Over/Under – Saturday, November 14

Indiana enters Saturday's game as a 9.5-point favorite against USC, returning a 1.28x payout if it wins outright, via PrizePicks — or $128 on a $100 entry if you’re right.

Here are the full payouts for USC vs. Indiana. PrizePicks data is live at the time of writing and is subject to change.

Make your USC vs. Indiana prediction on the spread on PrizePicks.

Despite a hot start, this year’s Indiana squad looks very different than the one that won a national title a season ago. The only blemish on the schedule is a narrow 19-15 loss to Ohio State last month, but the offense has been a concern lately.

The Hoosiers have averaged 32.4 points per game but have been held to 20 or fewer points in three of their last four contests. In fact, Indiana has needed overtime to beat Michigan (13-6) and Minnesota (23-16) in its two most recent games before the bye. 

Heading into Saturday’s game, head coach Curt Cignetti hasn’t revealed which quarterback will get the start. Both players are off the availability report, and Cignetti stated that QB Josh Hoover is available to play.

Hoover had been dealing with an upper-body injury and didn’t practice during the bye. Meanwhile, QB Grant Wilson, who replaced Hoover against Minnesota on October 31, didn’t practice due to the flu. 

Regardless of who is under center, Indiana may lean on a dynamic WR duo of Charlie Becker (875 yards and 9 TDs) and Nick Marsh (669 yards and 8 TDs). Both rank in the top 10 in the Big Ten in terms of receiving yards. 

Meanwhile, USC has also enjoyed an extremely satisfying campaign, owning losses to only Oregon and Wisconsin. Aside from Ohio State, USC is arguably the second-most talented team that Indiana has faced so far. 

The Trojans boast an electric offense that features QB Jayden Maiava, who leads the Big Ten in passing yards (2,524), completions (198), and passing TDs (20). Maiava has tossed multiple TD passes in six of his nine games in 2026. 

Maiava has a balanced group of pass catchers, including WR Trent Mosley, WR Kayden Dixon-Wyatt, WR Zacharyus Williams, and TE Mark Bowman. Mosley leads the team with 32 receptions for 512 yards and 6 TDs and has topped 100 yards in four of his six games.

Saturday’s contest could all come down to USC’s defensive acumen. The Trojans do boast a fairly strong run defense, allowing 124.8 YPG (eighth in the Big Ten). They’ve also held their opponents to 3.5 yards per carry or fewer in two of their last four contests.

USC vs. Indiana Prediction on Spread – 11/14/26

Here are the key stats and trends behind our USC vs. Indiana pick against the spread for Saturday, November 14.

• Indiana has a 1-8 against-the-spread record, while USC has covered in two of its last three contests.
• USC has averaged 294.4 passing YPG (second in the Big Ten) and posted a 0.31 EPA/dropback (ninth in the FBS).
• The Trojans also rank fourth in the conference in YPG (423.8) and averaged the fourth-most PPG in the Big Ten (32.4).
• Despite recording a 0.25 EPA/dropback, the Hoosiers have struggled offensively as of late, averaging 17.8 PPG in their last four games. 
• Hoover has completed just 16 of 37 passes for 200 yards and 1 TD with 2 INTs in his last two games. Meanwhile, Wilson completed 9 of 17 passes for 156 yards and a TD in relief against Minnesota.
• The Hoosiers have also struggled on late downs, tallying just a 42.5% success rate on third and fourth downs in 2026.

Lock in your USC vs. Indiana prediction on PrizePicks before kickoff.

USC vs. Indiana Picks, Player Stats for PrizePicks: 11/14/26

Here are the top USC vs. Indiana picks to target on Saturday, November 14. Today’s college football picks for PrizePicks include QB Jayden Maiava and WR Charlie Becker.

USC QB Jayden Maiava vs. Indiana: 233.5 Pass Yards

• Maiava has completed 66.9% of his passes for 2,524 yards and 20 TDS with 5 INTs in nine games.
• The Trojans’ signal-caller has thrown for 234+ yards in eight of his nine outings thus far.
• Maiava has recorded 0.33 EPA/dropback, whichs sits ninth among collegiate QBs.
• Ranking 20th at his position, Maiava has also averaged 7.89 yards per dropback. 

Pick Jayden Maiava + USC to win to your PrizePicks lineup now!

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Indiana WR Charlie Becker vs. USC: 88.5 Rec Yards 

• Becker has caught 50 passes for 875 yards and 9 TDs in nine games this season.
• The Hoosiers’ star wideout has recorded 100+ receiving yards in three of his last six contests.
• Becker's averaged 17.5 yards per reception, which is the sixth most among Big Ten pass catchers. 
• The USC defense has surrendered 0.19 EPA/dropback, good for just 110th nationally. 

Add Charlie Becker + Indiana to cover the spread to your PrizePicks lineup now.

Make USC vs. Indiana Picks on PrizePicks

Indiana’s offense has struggled extensively over the last month, and it’s unclear whether Josh Hoover or Grant Wilson will be under center on Saturday. As a result, USC could make life difficult for Indiana at home in this pivotal Big Ten showdown.

Don’t wait until kickoff — make your USC vs. Indiana picks on PrizePicks now.

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