Twins vs. White Sox Prediction, MLB Picks for Sunday Night Baseball – 9/6/26

After Chicago won a three-game series last week (2-1), the Twins (68-74) and White Sox (74-68) close another three-game series on Sunday Night Baseball, beginning at 6:20 p.m. ET on NBC. For Sunday, September 6’s battle, PrizePicks tabs the White Sox as the home favorite with a 1.63x payout if they win. 

Similar to last week, this series is coming down to a rubber match, with Chicago winning Game 1 (4-1), followed by Minnesota’s 6-4 win on Saturday. The White Sox continue to hold a narrow lead atop the American League Central, and the Twins are third in the division and 3.5 games behind the final AL Wild Card spot.

Let’s look at who could grab a much-needed win on Sunday Night Baseball, featuring a Twins vs. White Sox prediction and player picks for projections via PrizePicks.

Make your Twins vs. White Sox picks for Sunday Night Baseball on PrizePicks now!

{{mlb_offer_banner="/style-system/ui-components-playbook"}}

Twins vs. White Sox Prediction, Winner, Over/Under – Sunday, September 6

Neither club is playing its best ball right now. The Twins are 4-6 in the last 10 games, averaging 5.6 runs per game in the split. 

While that average is above Minnesota’s usual 4.7 runs per game (eighth), it’s inflated by 26 total runs over two matchups vs. the Tigers. Excluding those two matchups, the Twins recorded only 3.8 runs per game over the last eight matchups.

This series has been a story of two tales, featuring 1- and 6-run totals for Minnesota. Meanwhile, the White Sox have logged 4 runs in back-to-back contests. That’s a notable improvement compared to Chicago’s 2.3 runs per matchup over a six-game span from August 29 to September 3. 

The White Sox are only 2.5 games ahead of the Guardians for first place in the AL Central. Cleveland is 11-5 over its last 16 contests, putting suffocating pressure on Chicago. PrizePicks gives the Sox a 1.33x payout to win the division, followed by the Guardians’ 3.33x payout.

Minnesota is on its last breath for meeting its postseason goals, as it's 6.0 games behind the first-place White Sox. Furthermore, the Twins have four teams ahead in the Wild Card standings, featuring a 3.5-game margin for the final spot. According to PrizePicks, the Twins feature a 9.09x payout to qualify for the playoffs.

Which batting order can break out of inconsistency with a strong run total on Sunday Night Baseball? 

Chicago SP Bryan Hudson (4-4, 3.03 ERA, 2.94 xERA in 59.1 IP) has strong numbers, but he’s started in only seven of 61 appearances this season. Twins SP Bailey Ober (7-4, 4.37 ERA, 4.63 xERA in 21 GS) will make his 22nd start of the season tonight.

Twins vs. White Sox Winner Payout, Over/Under – Sunday, September 6

Sunday marks the third consecutive game with the White Sox favored vs. the Twins, featuring a 1.63x payout to win outright. 

Here are the full payouts for the Twins vs. White Sox game on PrizePicks Team Picks, including winner payouts, the spread, and over/under.

Make your Twins vs. White Sox prediction on the over/under on PrizePicks.

PrizePicks data is live at the time of writing and is subject to change.

Twins vs. White Sox Prediction on Winner for Sunday Night Baseball – 9/6/26

As mentioned, Bryan Hudson has primarily been used as a reliever this season. Over seven starts, the left-handed hurler hasn’t completed 2.0 innings of work once. 

That means the White Sox are fully preparing for a bullpen game, and Chicago’s relievers carry a 3.89 xERA over the last 30 days (17th), per FanGraphs. In Hudson’s last start, he was quickly lit up for 2 earned runs and 2 home runs in 1.0 inning of work.

While the Twins’ batting order has been up and down of late, they still possess good power. That includes a .408 SLG (seventh), a .162 ISO (10th), and 1.18 home runs per game (12th). With only 3.5 runs per game in this series, Minnesota still launched a big fly in back-to-back contests. 

Ober is likely the X-factor of this matchup. While his 4.88 xFIP initially tampers expectations, he’s excelled with a 2.51 ERA over his last three appearances. His last two outings featured only 3.0 hits allowed per start.

Keep in mind the White Sox have struggled to make contact with a .218 batting average over the last 14 days (26th). Limiting home runs has played a major piece in Ober’s recent success, surrendering only 1 tater across his previous three starts. That’s coming at an ideal time, as Chicago’s sluggers pose a threat with 1.31 dingers per game (fifth).

Ober has one start against the Sox this season, and it was a strong 5.0-inning showing while giving up only 1 earned run on August 29. 

Lock in your Twins vs. White Sox prediction on PrizePicks before the first pitch.

Twins vs. White Sox Picks, Player Stats for PrizePicks – 9/6/26

Here are top Twins vs. White Sox picks to target on PrizePicks for Sunday, September 6. Tonight’s MLB picks for PrizePicks include Bailey Ober and Colson Montgomery.

Twins SP Bailey Ober vs. White Sox: 4 Strikeouts

• Baseball Savant credits Ober with a lowly 16.6% strikeout rate (10th percentile), leading to only 3.8 strikeouts per start.
• His 28.7% chase rate (30th percentile) is a step above a 19.7% whiff rate (10th percentile), and that works in Ober’s favor considering Chicago swings at 31.2% of pitches outside the strike zone (24th percentile).
• Last week, Ober took advantage of the matchup by stacking 5 Ks.
• Dating back to the 2025 season, Minnesota’s starter totaled 4.5 strikeouts per start over two head-to-head matches with the division rival. 
• Chicago has the sixth-highest K rate in baseball (23.9%), and it’s maintained that number with a 23.6% mark over the last 30 days.

Add Bailey Ober to your PrizePicks lineup now.

{{mlb_offer_banner="/style-system/ui-components-playbook"}}

White Sox SS Colson Montgomery vs. Twins: 4 Hitter Fantasy Score

• Colson Montgomery reached the 30-home run mark in this series, launching his 30th and 31st big flies of the season over the last two days.
• This has boosted his SLG to .579 over five games in September, in line with an impressive 12.8% barrel rate (85th percentile) and 76.6 average bat speed (94th percentile).
• Montgomery’s 50.5% fly ball rate is well above the 39.0% league average, and his strong 19.5% home run-to-fly ball rate adds to his chance of going yard.
• Meanwhile, Ober allows a concerning 47.8% fly ball rate that contributes to his 1.43 HR/9. 
• According to Sports Reference, Montgomery has 1 home run over 4 at-bats in head-to-head matchups with Ober.
• Anchored by a 10.0 hitter fantasy score per game over his last five games, Montgomery’s slugging could be the main factor for this projection on Sunday Night Baseball.    

Add Colson Montgomery to your PrizePicks lineup now.

Make Twins vs. White Sox Picks for Sunday Night Baseball on PrizePicks

The White Sox hope to add to their AL Central cushion on Sunday Night Baseball, but leaning on their bullpen may lead to a difficult matchup against the Twins — especially with Bailey Ober pitching well of late.

Don’t wait until the first pitch — make your Twins vs. White Sox picks on PrizePicks now and earn real money if you’re right.

Pick players, predict More or Less on their stats, and cash in if you’re right. With Team Picks, you can make predictions on game winners, spreads, and over/unders, now available in 35 states.

Stay locked in on Playbook for daily MLB predictions, picks, and news every day all the way through the 2026 MLB season.